RI-OR2-TAT reduces the brain load of microglia and oxidative damage and stimulates neurogenesis in APP/PS1 transgenic mice. by Vadivel Parthsarathy (285723)

“…<p>Representative images of activated microglia in the cortical region of APP/PS1 mouse brains as shown by Iba1 immunostaining in animals treated with (<b>A</b>) 0.9% saline or (<b>B</b>) 100 nmol/kg RI-OR2-TAT in 0.9% saline; (<b>C</b>) quantitative analysis shows a decrease in mean microglial load in APP/PS1 mice treated with RI-OR2-TAT; detection of 8 oxo-guanine in the brains of animals treated with (<b>D</b>) 0.9% saline or (<b>E</b>) 100 nmol/kg RI-OR2-TAT; (<b>F</b>) quantitative analysis shows a decrease in mean 8 oxo-guanine staining in APP/PS1 mice treated with RI-OR2-TAT; detection of immature neurons as stained for doublecortin in the dentate gyrus of APP/PS1 mice treated with (<b>G</b>) 0.9% saline or (<b>H</b>) 100 nmol/kg RI-OR2-TAT; (<b>I</b>) quantitative analysis shows an increase in mean doublecortin staining in APP/PS1 mice treated with RI-OR2-TAT. …”

Plasma and hepatic reaction to acute estrogen exposure. by Clémentine Chalmey (5657233)

“…<b>a</b> shows an increase from PND0, <b>b</b> shows a decrease from PND1, <b>c</b> shows a decrease from PND3 and <b>*</b> shows a difference from the age-matched control group.…”

Data from: Viviparity does not affect the numbers and sizes of reptile offspring by Shai Meiri (394933)

“…However, our phylogenetically-controlled analysis of data on 1,259 squamate species revealed no significant differences in mean offspring size, clutch size or RI between oviparous and viviparous squamates. We attribute this paradoxical result to (1) strong selection on optimal offspring sizes, unaffected by parity mode, (2) the lack of a larval stage in amniotes, favouring large eggs even in the ancestral oviparous mode, and (3) the ability of viviparous females to decrease the mass of uterine embryos by reducing extra-embryonic water stores. …”

E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy by Jennifer L. Major (3639472)

“…Using the Seahorse platform, a 22% decrease in glycolysis was noted in neonatal cardiomyocytes isolated from E2F6-Tg hearts. …”

Supplementary Material for: Fluctuations in Cognitive Test Scores and Loss to Follow-up in Community-Dwelling Older Adults: The IRIDE Cohort Study by Abe T. (4146577)

Down-regulation of NNMT expression inactivated Akt and ERK1/2. by Jun Zhang (48506)

“…Each group of cells were seeded into 6-well plates with or without IGF-1 at a final concentration of 100 ng/ml. Apoptotic cells population was determined after incubation for 48 h. 100 ng/ml IGF-1 decreased the apoptosis significantly in NNMT knockdown Bcap-37 and MDA-MB-231 cells compared to negative control. …”

Pheromone-responding ORNs and MGC calcium responses in virgin and mated males. by Nina Deisig (178118)

“…<p><b>A</b>) Typical single sensillum recordings showing an olfactory receptor neuron (ORN) excitatory response to the pheromone (10 ng), no response to heptanal (100 µg) and a reduced response to the pheromone/heptanal mixture in a virgin male. …”

Supplementary Material for: Deranged Iron Status Evidenced by Iron Deficiency Characterizes Patients with Hidradenitis Suppurativa by Ponikowska M. (8280024)

“…<b><i>Results:</i></b> Compared with controls, patients with HS demonstrated a deranged iron status as evidenced by decreased levels of ferritin (91 ± 87 vs. 157 ± 99 µg/L), Tsat (21.5 ± 10.8 vs. 42.2 ± 11.7%) and hepcidin (31.3 ± 25.9 vs. 44.2 ± 22.0 ng/mL) (all <i>p</i> < 0.05 vs. controls). …”

Data_Sheet_1_Carbon on the Northwest European Shelf: Contemporary Budget and Future Influences.PDF by Oliver Legge (8591469)

“…Benthic carbon stocks will be affected by increasing temperature and acidity, and decreasing oxygen concentrations, although the net impact of these interrelated changes on carbon stocks is uncertain and a major knowledge gap. …”

Mathematical model predictions of the detyrosination inhibition with experimental validation in proliferative cells. by Jeremy Grignard (12963351)

“…The BIOCHAM commands used are: change_parameter_to_variable(k1), dose_response(k1, 0, 10, time:100, show:TyrDetyr). The BIOCHAM command draws a dose-response diagram by linear variation of the initial concentration (the dose) of the input object, here <i>k</i>₁, and plotting the output object (the response), here the molecular species: Tyr, Detyr and TyrDetyr, showing an increase of the tyrosination status with a decrease of <i>k</i>₁. …”

Assessment of sesquiterpene lactones isolated from <i>Mikania</i> plants species for their potential efficacy against <i>Trypanosoma cruzi</i> and <i>Leishmania</i> sp. by Laura C. Laurella (469416)

“…More importantly, while 100% of control mice died by day 22 after receiving a lethal <i>T</i>. …”

Optimal Filtering Cutoff Frequency Is Determined by the Signal and Noise by Burton W Andrews (274358)

“…If the signal PSD is then increased (red solid line), for example, by increasing the effect of rotational diffusion, the cutoff frequency increases (point C). Parameters used for point A: <i>u</i> = 20 μm/s, <i>D_r</i> = 0.16 rad²/s, τ = 1 s, <i>R_T</i> = 2.5 μM, <i>k</i>₋/<i>k</i>₊ = 100 μM, <i>g</i> = 0.03 μM/μm, and binding is assumed at steady state with a ligand value of <i>L</i>₀ = 1 μM. …”

Immunofluorescence for autophagic proteins following DMBA treatment. by Evie H. Carchman (3195855)

“…(C) An overlay image with co-expression (LC3β and p62) expressed as orange at the 5 week time point compared to LC3β alone in panel B indicates a mild increase in p62 in addition to LC3β at this time point. …”

Kidney function. by Lena Wester-Rosenlöf (515985)

“…For Ficoll_{70 Å}, θ was 1.80×10⁻³±5.54×10⁻⁴ and 1.18×10⁻²±5.84×10⁻³ (p<0.055), starved placebo and starved+A1M respectively. …”

ndrg4 function is required for the expression of several genes that are essential for vesicle docking. by Laura Fontenas (3371204)

“…<p>(A) qPCR showing a significant decrease in the expression of nsfa, syt1a, stxbp1b but not vamp2 in ndrg4 mutants with mRNA relative expression to ef1a. …”

Ca²⁺ induced swelling in isolated mitochondria. by Jun Li (6494)

“…<p>(<b>A</b>) Representative traces of 100–1000 µmol/L Ca²⁺ induced a decrease in light transmission in the ischemia/reperfusion (I/R) 24 h group. …”

S1 Data - by Ranjeeta Adhikari (9905958)

“…Statistical comparisons between tolerant and sensitive cultivars in the N-deficient treatment indicated an increase in shoot biomass (19.9 vs 14.4 g), leaf area (2775 vs 1824 cm²), leaf dry weight (14.7 vs 10.0 g), lateral root dry weight (3.7 vs 2.4 g), light-saturated photosynthesis (14.5 vs 10.1 μmol∙m^-2∙s^-1), maximum electron transport rate (119 vs 89 μmol∙m^-2∙s^-1), chlorophyll content (28.1 vs 12.9 g∙100g^-1), leaf N content (27.5 vs 19.9 mg∙g^-1), and fine root N content (26.1 vs 20.9 mg∙g^-1), and a decrease in anthocyanin content (0.07 vs 0.16 ΔOD∙g^-1). …”

Characterization of CLU-isoform biogenesis. by Hans Prochnow (461311)

“…(B) Western blots of recombinant CLU-V5 proteins in lysates (upper panel) and culture media (lower panel) of HEK-293 cells transiently expressing unmodified or point-mutated (crossed out codons) CLU cDNA variant 1. …”

The effects of PRP or HGF treatment on COX-1 protein expression in tendon cell culture by immunostaining. by Jianying Zhang (256508)

“…The addition of HGF antibody to tendon cell cultures decreased the reduction by PRP or HGF treatments. <b>A:</b> SF (control conditions); <b>B:</b> IL-1β (1 ng/ml); <b>C:</b> 2%PRP+ IL-1β; <b>D:</b> 10%PRP+IL-1β; <b>E:</b> HGF+IL-1β; <b>F:</b> 2%PRP+IL-1β+AB; <b>G:</b> 10%PRP+IL-1β+AB; <b>H:</b> HGF+IL-1β+AB; <b>I:</b> 2%PRP; <b>J:</b> 10%PRP; <b>K:</b> HGF (1 ng/ml) and <b>L:</b> HGF+AB (10 ng/ml). …”

Microglial expression of HLA-DP, DQ, DR is increased by IFNy, not changed by TGFβ₁, and reduced by M-CSF. by Amy M. Smith (493523)

“…E) M-CSF (25 ng/ml) reduced basal HLA-DP, DQ, DR expression in microglia and also decreased IFNy-enhanced HLA-DP, DQ, DR expression in microglia (F). …”