Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Protein-protein docking for Parkin and a charged E2∼Ub complex. by Thomas R. Caulfield (655752)

“…The docking in the same position is shown and rotated 180° to reveal the other side. Residues of the Ubch5a-Ub complex are indicated by color (dark green and brown, respectively). …”

Cerebral Venous Sinus Thrombosis - Diagnostic Strategies and Prognostic Models: A Review by Penka A. Atanassova (7944506)

“…Patients with CVST commonly present with headache, although some develop a focal neurological deficit, decreased level of consciousness, seizures, or intracranial hypertension without focal neurological signs. …”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

The Effect of Chronic Stress on Apoptosis Regulation and Oncogenesis Evolution: A Theoretical Approach. by DIMITRIOS KIMOGLOU (20499350)

Pyrvinium inhibits WNT signaling in a CK1α dependent manner. by Bin Li (39349)

“…<p><b>A</b>. The expression of the WNT target gene: <i>AXIN2</i> was determined from NIH 3T3 cells expressing control or <i>CK1α</i>-specific shRNAs. …”

Supplementary Material for: Differential Impact of Cognitive Impairment in MCI Patients: A Case-Based Report by Pergher V. (9038528)

Data_Sheet_1_Are Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality?.PDF by Francisco C. Ceballos (8065037)

The BCM rule feedforward connection shows a hysteresis in pre- and postsynaptic stimulation. by Michael Fauth (683879)

“…<i>(C)</i> Simulation reveals the predicted hysteresis: postsynaptic stimulation was increased stepwise such that <i>v</i>_<i>i</i>(<i>S</i> = 0) increased by steps of 0.01 until it reached 1.0 and then decreased again. …”

Expression pattern of a <i>puc</i> reporter line in the central brain. by David Kapfhamer (295513)

“…<p><b><i>A</i></b>, Rescue of decreased <i>puc¹/+</i> ethanol-induced locomotor stimulation in the <i>NP1311</i> expression pattern. …”

Supplementary Material for: Trends in Literature on Cerebral Bypass Surgery: A Systematic Review by Grüter B.E. (11166240)

“…<b><i>Methods:</i></b> A systematic literature research was conducted using PubMed, Web of Science, EMBASE, and SCOPUS databases. …”

RECQL4 functions in a separate pathway from REV1 and is degraded following DNA crosslinks. by Thong T. Luong (13833935)

Ligand-dependent stability of a 240 kDa protein can be probed by FASTpp. by David P. Minde (304427)

“…A gradual decrease in the band intensity at higher temperatures indicates unfolding. …”

Acute Variations in Retinal Vascular Oxygen Content in a Rabbit Model of Retinal Venous Occlusion by Gilberto Raul Lopez Jaime (120485)

“…</p> <h3>Results</h3><p>One hour after RVO induction, we observed statistically significant reductions in the intravascular oxygen saturation in temporal retinal arteries (85.1±6.1% vs. 80.6±6.6%; p<0.0001) and veins (71.4±5.5% vs. 64.0±4.7%; p<0.0001). …”

SIRT1 preserves dendritic integrity in hippocampal neurons challenged with Aβ fibrils. by Juan F. Codocedo (304388)

“…(<b>B,C</b>) Normalized TDBTN (B) and coverage area (C) of experimental conditions shown in (A). (<b>D</b>) Sholl analysis of transfected neurons: GFP (black circles), GFP + Aβ 5 µM (with circle), SIRT1/GFP + Aβ 5 µM (red triangle), SIRT1H363Y/GFP + Aβ 5 µM (blue triangle). …”

Detection of ENFs in <i>α</i>-GalA KO males frontal paws. by Jarmila Lakomá (152379)

“…<p>The DAPI immunostaining of 50 µm floating sagittal mice frontal paw section with marked region of interest (A). The immunohistochemistry of <i>α</i>-GalA KO males (n = 3) revealed the scattered expression of PGP9.5 (red) - specific marker of neuronal terminations in the epidermis of frontal paw skin in comparison to their WT controls (n = 3). …”

Characterization of JTA009, a novel anti-human ICOS mAb by Manabu Kawamoto (18939)

“…</p><p>Published online 22 Mar 2006</p><p>PMCID:PMC1526621.</p><p></p> JTA009, a fully human anti-human ICOS mAb, has greater avidity than SA12. …”

Data_Sheet_1_A scientifically validated combination of garcinol, curcuminoids, and piperine for mild to moderate nonalcoholic steatohepatitis patients—results from a randomized, do... by Muhammed Majeed (659312)

“…</p>Methods<p>The patients received one tablet (450 mg) of GCP containing garcinol-50 mg, curcuminoids −250 mg and piperine 5 mg or a placebo (450 mg of microcrystalline cellulose) twice daily for 90 days. …”

Extended use of poultry manure as a nutrient source for flood-irrigated rice crop by Fabiana Schmidt (8465247)

“…<div><p>Abstract: The objective of this work was to evaluate changes in the soil chemical properties, nitrogen use efficiency, and grain yield of flood-irrigated rice fields after the addition of poultry manure during five years. Trials were carried out in a randomized complete block design, with three replicates. …”