Type 2 diabetes and COVID-19 related mortality in the critical care setting: A national cohort study in England, March-July 2020 by John M. Dennis (8929895)

“…</p> <p><b>Results: </b>19,256 COVID-19 related HDU and ICU admissions were included in the primary analysis, including 13,809 HDU (mean age 70), and 5,447 ICU admissions (mean age 58). 3,524 (18.3%) had type 2 diabetes. 5,077 people (26.4%) died during the study period. …”

Data Sheet 3_Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis.pdf by Wenting Song (822582)

“…Compared with the control group, the treatment group demonstrated better performance in reducing neurological impairment score [SMD = −0.99, 95% CI −1.24, −0.73], improving overall efficacy [RR = 1.22, 95% CI 1.14, 1.30] and ADL score [SMD = 2.01, 95%CI 1.55, 2.46], as well as decreasing the cerebral hematoma volume [MD = −6.98, 95% CI −8.76, −5.20] and cerebral edema volume [MD = −3.67, 95%CI -5.27, −2.06], with statistically significant differences observed. …”

Image_1_Application of hot water and cold air to reduce bacterial contamination on broiler carcasses.TIF by Anja Beterams (19699861)

“…The effect of heat treatment for Campylobacter was smaller when samples were analyzed with v-qPCR with reductions of 0.5–0.8 log₁₀ IPIU/ml in mean. …”

Data Sheet 2_Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis.pdf by Wenting Song (822582)

“…Compared with the control group, the treatment group demonstrated better performance in reducing neurological impairment score [SMD = −0.99, 95% CI −1.24, −0.73], improving overall efficacy [RR = 1.22, 95% CI 1.14, 1.30] and ADL score [SMD = 2.01, 95%CI 1.55, 2.46], as well as decreasing the cerebral hematoma volume [MD = −6.98, 95% CI −8.76, −5.20] and cerebral edema volume [MD = −3.67, 95%CI -5.27, −2.06], with statistically significant differences observed. …”

Data Sheet 1_Efficacy and safety of Shuxuening injection in intracerebral hemorrhage: a systematic review and meta-analysis.pdf by Wenting Song (822582)

“…Compared with the control group, the treatment group demonstrated better performance in reducing neurological impairment score [SMD = −0.99, 95% CI −1.24, −0.73], improving overall efficacy [RR = 1.22, 95% CI 1.14, 1.30] and ADL score [SMD = 2.01, 95%CI 1.55, 2.46], as well as decreasing the cerebral hematoma volume [MD = −6.98, 95% CI −8.76, −5.20] and cerebral edema volume [MD = −3.67, 95%CI -5.27, −2.06], with statistically significant differences observed. …”

Image 1_Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage.jpeg by Peter Linde (22011383)

“…STING-MSC-CM decreased IL-6, IL-8 secretion (p = 0.08) by synoviocytes, decreased IL-8 (p = 0.05) by activated chondrocytes, increased G-CSF (p = 0.01), IL-4 (p = 0.01) and decreased IL-5 (p = 0.01) by activated macrophages. …”

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study by Robert Molokie (4419409)

CDMS quantification of Impβ-capsid complexes indicates saturable, ionic strength-sensitive binding of Impβ. by Chao Chen (195669)

“…<p>(a) The mean number of Impβ bound to Cp183 capsids decreases as a function of NH₄HCO₂ concentration. …”

Enhanced preservation of the human intestinal microbiota by ridinilazole, a novel <i>Clostridium difficile</i>-targeting antibacterial, compared to vancomycin by Cheleste M. Thorpe (5586599)

“…Changes in the microbiota were assessed using qPCR and high-throughput sequencing on participants’ stools collected at multiple time-points (baseline [Day 1], Day 5, end-of-treatment [EOT; Day 10], Day 25, end-of-study [EOS; Day 40], and at CDI recurrence). qPCR analyses showed profound losses of <i>Bacteroides</i>, <i>C</i>. …”

Supplementary Material for: Spatiotemporal characterisation of key cortical developmental markers in the developing ferret brain by figshare admin karger (2628495)

“…In doing so, the study sought to establish a foundational, descriptive atlas of neurodevelopmental marker expression across key time points and cortical regions and layers. Methods Immunofluorescent labelling of key neural progenitor and neuronal markers was performed on coronal ferret brain sections at embryonic (E34, E38) and postnatal (P2, P5, P15, P25) ages. …”

Sensitivity analysis. by Stefano Merler (42326)

“…<p><b>A</b> Estimated epidemic prevention potential (points) and 95%CI (vertical lines) as a function of <i>R_e</i> and by varying the vaccine coverage. …”

Pulpal blood flow changes and pain scores related to using Superelastic 0.018-inch Nickel Titanium as the first orthodontic alignment archwire: a prospective clinical trial by Elham S. Abu ALHAIJA (12681456)

“…A repeated measures ANOVA and a post-hoc Bonferroni comparison tests were conducted to examine differences at the different time points before and during orthodontic alignment. Results For all studied archwire sizes, PBF decreased 20 minutes after their placement. …”

Table_1_Moderate Dietary Protein Restriction Optimized Gut Microbiota and Mucosal Barrier in Growing Pig Model.DOCX by Xiyue Chen (5527046)

“…Ileal abundances of Streptococcaceae and Enterobacteriaceae decreased respectively, while beneficial Lactobacillaceae, Clostridiaceae_1, Actinomycetaceae, and Micrococcaceae increased their proportions with a protein reduction of 3 percentage points. …”

Lowering cardiolipin levels can suppress cold sensitivity of the Δ<i>yhdP</i> Δ<i>fadR</i> strain. by Ashutosh K. Rai (18874704)

“…For ratios individual data points are indicated with open circles. * p<0.05 vs. …”

Relating the biophysical forces that govern bacterial adhesion to experimental data. by Mikkel Anbo (15287803)

“…<p>A: We show that the relative polarity of the expressed serotype correlates with adhesion to tissue culture polystyrene. …”

B-Myb binds to and regulates Oct4 promoter activity. by Kirill V. Tarasov (75912)

“…The presence of an amplification product in the anti-B-Myb immunoprecipitated DNA indicates that B-Myb binds a proximal region of the mouse <i>pou5f1</i> promoter. B) In the second set of experiments, which were evaluated by qRT-PCR, we find that B-MYB dynamically binds to the endogenous <i>pou5f1</i> promoter region. …”

Feedback patterns of avian longitudinal-experimental immune responses against West Nile Virus. by Ariel L. Rivas (155906)

“…The 3D relationship that included the heterophil (N) %, the ratio of N per lymphocyte (N/L), and the mononuclear cell/N (macrophage plus lymphocyte/N or MC/N) ratio showed three major data inflections: 1) a double 90-degree inflection was observed between pre-inoculation (0 dpi) and one day post-inoculation (1 dpi) data points (green arrow), indicating that the N/L ratio increased within a 24-hour period, and that high N/L observations were D+ (red symbols); 2) at, approximately, 5 dpi, a second data inflection was observed (red arrow), which was associated with high MC/N and low N/L values; and 3) soon after 5 dpi, the third data inflection took place, indicating the beginning of the return to the steady state phase (blue arrow). …”

The physical, biological, and genetic basis of myopia. by Robert Wojciechowski (399469)

“…Red dots show SNPs that were genomewide significant (GWS; p<5e-08, −log₁₀(p)>7.3) in both studies. …”

Inappropriateness of Medication Prescriptions to Elderly Patients in the Primary Care Setting: A Systematic Review by Dedan Opondo (140380)

“…The median rate of inappropriate medication prescriptions (IMP) was 20.5% [IQR 18.1 to 25.6%.]. Medications with largest median rate of inappropriate medication prescriptions were propoxyphene 4.52(0.10–23.30)%, doxazosin 3.96 (0.32 15.70)%, diphenhydramine 3.30(0.02–4.40)% and amitriptiline 3.20 (0.05–20.5)% in a decreasing order of IMP rate. …”

Complement evasion factor (CEF), a novel immune evasion factor of <i>Streptococcus pyogenes</i> by Haniyeh Aghababa (12020666)

“…Using recombinant Spy0136 in a pull-down assay with human plasma and ELISA, we have identified four complement proteins (C1r, C1s, C3, and C5) as binding partners. …”