AMPK activation reduced SREBP-2 protein and target gene expression in the livers of AICAR-treated <i>Tshr</i>^<i>-/-</i> and <i>Tshr</i>^<i>+/+</i> mice. by Shudong Liu (733425)

“…<p>(A) SREBP-2 protein levels were decreased in <i>Tshr</i>^<i>-/-</i> mice (n = 3 animals/group), Densitometric quantifications of SREBP-2 (P) and SREBP-2 (N) are shown. …”

Dose-dependent cVA response and desensitization by prolonged stimulation in Or67d ORNs. by Shin-Ichiro Tachibana (707681)

“…During the 15 minutes CE, the response to 200 ng cVA was decreased and thereafter the acute response to 10 pg cVA also decreased. …”

From Schooling to Shoaling: Patterns of Collective Motion in Zebrafish (<em>Danio rerio</em>) by Noam Miller (120315)

“…Examining zebrafish groups of different sizes from 5 to 50, we show that larger groups are less polarized than smaller groups. …”

The average distance between the the most frequent phenotypes and the patchiness of the visible phenotypic subspace. by Elhanan Borenstein (68815)

“…We also calculate which fraction of all visible phenotypes are included in these phenotypes (solid line). …”

Quality, safety and efficiency in practice: Risk assessment and standardisation of anesthesia equipment and supplies in operating theaters of high-volume tertiary-care academic med... by Hammad Y.

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Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells by Alshwyeh, Hussah Abdullah

“…We utilized MTT and BrdU cell proliferation assays, morphological assessments, cell cycle analyses, and apoptosis assays to investigate the extract’s effects on lung cancer (A549 and NCI-H292) and normal lung (MRC-5) cells. …”
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Role of Graphene Oxide in Bacterial Cellulose−Gelatin Hydrogels for Wound Dressing Applications by Khan, Muhammad Umar Aslam

“…The hemolysis of all hydrogel samples is less than 0.5%, and the blood coagulation time decreased as the hydrogel concentration increased. …”
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Influence of an elevated CO2 level on life history parameters and hormone pathway or vitellogenin metabolism of the brown planthopper.zip by Yanhui Wang (11324715)

“…We have demonstrated that elevated CO₂ could accelerate the development and improve reproduction of <i>N. lugens</i>, which is related to the transcription levels of JH, MH and Vg.…”

Image_3_Creation of Early Flowering Germplasm of Soybean by CRISPR/Cas9 Technology.png by Jianan Han (7911278)

“…In addition, no off-target effects were observed by predicting and analyzing the potential off-target sites of E1 targets. Significant decreased E1 gene expression of two novel mutants showed that the truncated E1 protein disinhibited GmFT2a/5a and increasing GmFT2a/5a gene expressions resulted obvious early flowering. …”

DataSheet_1_Turbulence affects larval vertical swimming in the cold-water coral Lophelia pertusa.pdf by Vilhelm Fagerström (14234933)

“…Larval movement and water flow were simultaneously recorded, allowing for analysis of individual larval swimming velocities. We showed that the upwards directed swimming speed generally decreased with increasing turbulence, dropping to non-significant in turbulence levels occurring near ocean boundaries. …”

Supplementary file 1_Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomi... by Abdullah M. Sayed Ahmad (18592582)

“…</p>Methods<p>Fourteen participants with chronic SCI received an average of 40 sessions with 30 Hz transspinal stimulation delivered for 30 min during standing (active: n = 4; sham: n = 5) or supine (active: n = 5) followed by 30-min of robotic assisted step training. …”

Data_Sheet_1_Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning.PDF by Taiyi Wang (6305579)

“…Our main findings are: (1) On ECG recorded in isolated rat, in the presence of XSN the amplitude of R wave was significantly decreased and the amplitude of T wave was increased significantly; (2) XSN blocked hNaV1.5 channel stably transfected cell line in a dose-dependent manner with an IC₅₀ of 0.18 ± 0.02 g/L; and (3) XSN suppresses hERG channels in a dose-dependent manner with an IC₅₀ of 0.34 ± 0.01 g/L. …”

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks by Sofia Benfeito (4345591)

“…Although the lipophilic triphenylphosphonium (TPP⁺) cation is widely used to target antioxidants to mitochondria, TPP⁺-based derivatives have shown cytotoxicity in several biological <i>in vitro</i> models. We confirmed that <b>Mito.TPP</b> is cytotoxic to both human neuronal (SH-SY5Y) and hepatic (HepG2) cells, decreasing intracellular adenosine triphosphate (ATP) levels, leading to mitochondrial membrane depolarization and reduced mitochondrial mass after 24 h. …”

Image_6_Creation of Early Flowering Germplasm of Soybean by CRISPR/Cas9 Technology.png by Jianan Han (7911278)

“…In addition, no off-target effects were observed by predicting and analyzing the potential off-target sites of E1 targets. Significant decreased E1 gene expression of two novel mutants showed that the truncated E1 protein disinhibited GmFT2a/5a and increasing GmFT2a/5a gene expressions resulted obvious early flowering. …”

DataSheet_1_Creation of Early Flowering Germplasm of Soybean by CRISPR/Cas9 Technology.docx by Jianan Han (7911278)

“…In addition, no off-target effects were observed by predicting and analyzing the potential off-target sites of E1 targets. Significant decreased E1 gene expression of two novel mutants showed that the truncated E1 protein disinhibited GmFT2a/5a and increasing GmFT2a/5a gene expressions resulted obvious early flowering. …”

Table_11_Neutrophil extracellular traps promote bronchopulmonary dysplasia-like injury in neonatal mice via the WNT/β-catenin pathway.xls by Liujuan Sun (15364594)

“…The WNT/β-catenin pathway is one of the most well-known signalling pathways involved in lung growth. We found that the expression of the target genes c-MYC, cyclin D, and vascular endothelial growth factor (VEGF) and the important proteins WNT3a and β-catenin significantly decreased. …”

Table 4_Morphophysiological and transcriptomic analyses during the development of microspores and megaspores in Orobanche coerulescens.xlsx by Kelin Cui (20936231)

“…We also investigated the key regulatory genes in the metabolic pathways of phytohormones that are closely related to the development of microspores and megaspores using transcriptome sequencing technology.…”

Data_Sheet_2_Role of Downregulation and Phosphorylation of Cofilin in Polarized Growth, MpkA Activation and Stress Response of Aspergillus fumigatus.PDF by Xiaodong Jia (783460)

“…Expression of non-phosphorylated cofilin with a mutation of S5A had little impacts on A. fumigatus, whereas expression of a mimic-phosphorylated cofilin with a mutation of S5E resulted in inhibited growth, increased phospho-MpkA level, and decreased pathogenicity. …”

Table_1_Turbulence affects larval vertical swimming in the cold-water coral Lophelia pertusa.pdf by Vilhelm Fagerström (14234933)

“…Larval movement and water flow were simultaneously recorded, allowing for analysis of individual larval swimming velocities. We showed that the upwards directed swimming speed generally decreased with increasing turbulence, dropping to non-significant in turbulence levels occurring near ocean boundaries. …”

DataSheet_1_Turbulence affects larval vertical swimming in the cold-water coral Lophelia pertusa.pdf by Vilhelm Fagerström (14234933)

“…Larval movement and water flow were simultaneously recorded, allowing for analysis of individual larval swimming velocities. We showed that the upwards directed swimming speed generally decreased with increasing turbulence, dropping to non-significant in turbulence levels occurring near ocean boundaries. …”