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MK-STYX decreases RhoA activation.
Published 2014“…<p>(<b>A</b>) PC12 cells were transfected with pMT2 or pMT2-FLAG-MK-STYX-FLAG. 24 hr post-transfection cells were stimulated with 100 ng/ml NGF, and lysed at the indicated time points. …”
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In the absence of chloride, two-fold decrease in [Na<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −28 mV at both low and high glutamate concentrations.
Published 2015“…<b>(B)</b> Representative data show total membrane current, the time courses of [Na<sup>+</sup>]<sub>e</sub>, [Glu<sup>-</sup>]<sub>e</sub>, and [DHK]<sub>e</sub> at the top, and HP voltage ramps (–100 to +20 mV) at the bottom. Arrow head points to simultaneous decrease in [Glu<sup>-</sup>]<sub>e</sub> and [Na<sup>+</sup>]<sub>e</sub>, which affects the current. …”
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Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in <i>Neisseria gonorrh...
Published 2010“…However, we observed that the minimum inhibitory concentrations (MICs) of penicillin, ceftriaxone, and cefixime for a wild-type strain (FA19) containing a <i>penA</i> gene with these three mutations increased only 1.5-, 1.5-, and 3.5-fold, respectively. …”
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TRIM5 restriction of HIV-1 has decreased during evolution leading to humans.
Published 2013“…Original data is found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000301#pbio.1000301-Goldschmidt1" target="_blank">[30]</a> and shows that the antiviral gene TRIM5 restricted HIV-1 better at points in evolution earlier than the chimp–human common ancestor than it does after that. …”
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FUD transiently decreased IOP in mice injected with Ad5-TGFβ2 viral vector.
Published 2020“…(B) IOPs were monitored for 5 more days (until Day 22) in a subset of mice from A. …”
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Eltrombopag markedly decreases levels of ROS in MOLM14 cells.
Published 2015“…B) Graphic presentation of ROS levels measured by flow cytometry in cells treated with E (5 μM) or DPI (25 μM), an inhibitor of NADPH oxidase known to decrease an intracellular level of ROS, or untreated (CTR) cells. …”
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