Co-immunoprecipitation of CFTR, HSPs, VCP, and HDAC6 in the N1303K and S1235R cell lines treated or untreated with the compounds. حسب Daniele Rapino (506785)

"…<p>HEK 293 cell lines stably expressing either mutant were treated with C3+C4 (5μM), and CFTR was immunoprecipitated with anti-CFTR antibody M3A7. …"

Profiling the RNA levels of cancer-related genes in the analysed FMCs. حسب Daniela Ferreira (173362)

"…Each quantification graphic also presents the percentage of tumours with increase (≥2-folds), maintenance (between 0.5 and 2-folds) or decrease (≤0.5-folds) RNA levels of each gene. …"

Effects of L-DOPA on the expression of DMT1−IRE, DMT1+IRE, Fpn1 and TfR1 proteins in cortical neurons. حسب Fang Du (232423)

"…L-DOPA treatment induced a dose-dependent decrease in TfR. There were no significant differences in the levels of DMT1+IRE and Fpn1 protein between neurons treated with and without L-DOPA. * P<0.05, ** P<0.01 vs. the control.…"

Treatment with dexamethasone prior to secondary live virus infection prevents airway hyperreactivity only in sensitized animals. حسب Christopher Skappak (417305)

"…<p>Some animals were treated with dexamethasone (i.p.) before the second live PIV infection. <b>(A)</b> Dexamethasone treatment of non-sensitized animals before secondary infection with PIV (n = 6) had no effect on bronchoconstriction in response to histamine (i.v.), compared to untreated animals (n = 5). …"

Changes in ambient noise spectrum during moonlight hours. حسب Daniel Duane (18189603)

"…<p>Changes in the spectrum of ambient noise during moonlight hours are shown in June 2020, a month where significant changes in biological noise are observed in all three frequency bands studied. …"

Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells and in xenografts: Identification of apoptotic genes as targets for demethylation-4 حسب Khaldoun Al-Romaih (79731)

"…There was a significant decrease (p < 0.001) in methylation quantity for each CpG position after decitabine treatment both and for the four genes in all sample but not in the NHOst (normal human osteoblasts). p-values were calculated by comparing the percentage of methylation for each individual CpG position in control cells with the same CpG position in the treated cells using student t-test and they all resulted in p < 0.001.…"

Figure 1 from Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells حسب Stacia L. Koppenhafer (16616290)

"…<p>HDAC inhibitors decrease RRM1, RRM2, CHK1, and WEE1 protein levels. …"

Notch and Wnt signaling-mediated activation of Müller cells in S334ter rats <i>in vivo</i>. حسب Carolina Beltrame Del Debbio (243080)

"…Q-PCR analysis of gene expression revealed increase in levels of transcripts corresponding to <i>Ki67</i>, <i>cyclinD1</i>, <i>Hes1</i>, <i>Hes5</i> and decrease in <i>p27^kip1</i> transcript levels in Jag1+Wnt2b treated retina, compared to controls (<b>H</b>). …"

Gene expression analysis of <i>Pten</i> mutant prostates. حسب Isabel B. Lokody (755298)

"…<p>(A) i) Heatmap demonstrating that control samples (C1-C5) show similar expression patterns to each other, as do mutant samples (M1-M5). ii) Genes chosen for validation are indicated in heatmap derived from the average of control and mutant samples. …"

Summary of phenotypic data of the candidate genes implicated in HR-DSBR. حسب Mikołaj Słabicki (246635)

"…Genes that after knockdown decreased the frequency of HR below z-score −4, −2, or −1.5 are marked with ↓↓↓, ↓↓ or ↓, respectively; genes that increase the frequency of HR over z-score 4, 2, or 1.5 are marked with ↑↑↑, ↑↑, or ↑, respectively; n.a., not available. …"

Waterfall plot showing the quantitative changes in ER, PR, and Ki-67 expression. حسب Yuqin Ding (623253)

"…(A) ER discordance rate: 10.4% (50/482) of patients, including 36 (7.5%) patients with positive-to-negative conversion and 14 (2.9%) patients with negative-to-positive conversion; (B) PR discordance rate: 17.0% (82/482) of patients, including 57 (11.8%) patients with positive-to-negative conversion and 25 (5.2%) patients with negative-to-positive conversion; (C) Ki-67 discordance rates: 50.4% (243/448) of patients had decreased expression and 27.0% (130/448) of patients had increased expression.…"

Phosphorylation of PKA targets is greatest when PKA is colocalized with cAMP production either in the spine or in the dendrite. حسب Myungsook Kim (2166613)

"…(A2) Bar graph shows mean and s.e.m. of phospho-inhibitor-1 (n = 5 for each condition). …"

IL-1β depletion and IL-1 receptor antagonist treatment alleviated the neutrophilic inflammation. حسب Wen-Cheng Chao (2817868)

"…<p>The characteristic pulmonary histopathological images (A) of <i>M</i>. <i>marinum</i>-infected <i>Ncf1</i>^<i>-/-</i> mice and WT mice on day-5 with and without IL-1β depletion by a monoclonal antibody directed against IL-1β (150μg on day-1). …"

Patient in chronic hemodialysis with right atrial mass: thrombus, fungal endocarditis or atrial myxoma? حسب Talita G. Salani (12731018)

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat حسب Malene Brohus (840080)

"…They are established contributors to the aging process, confirmed by the demonstration that decreased IGF signaling results in life-extending effects in a variety of species. …"

hTTR levels in serum and stomach. حسب Elena Panayiotou (3925415)

"…<p>hTTR immunoblotting exhibiting a single band at 14KDa (<i>A</i>). hTTR levels measured via immunoblotting in serum of V30M and V30M C1q KO animals of all three age groups indicating higher hTTR in the V30M mice and a gradual decrease in the amount of hTTR present as the animals age (<i>B</i>). hTTR levels measured via immunoblotting in stomach tissue of the V30M and V30M C1q KO animals exhibit a severe decrease in the second age group (<i>C</i>). …"

Effect of temporal control of the Raf/MEK/ERK pathway on PC12 neurite outgrowth. حسب Kai Zhang (102844)

"…When the off-time exceeded 45 min, neurite length gradually decreased. ***p<0.001. (C) The average neurite length induced by intermittent light stimulation with a 45-min on-time and various off-times at 27, 45, 75, 135, 315 min. …"

DataSheet_1_Treatment Interruptions During Stereotactic Body Radiotherapy for Prostate Cancer.docx حسب Abigail N. Pepin (11966438)

"…Median length of time to complete treatment was 11 days (range 5–155 days). In patients who experienced a delay, nearly half (45.5%) experienced only a one-day delay. …"

Examination of known somatic cell B-Myb target gene expression patterns following knockdown of B-Myb in ESCs. حسب Ming Zhan (27937)

"…B) RNA (left) and protein (right) analysis of the B-MYB target gene Polo-like kinase 1 (Plk1) following Bγ-Myb KD with shRNA1 and shRNA5. The effects of B-MYB KD on Plk1 RNA were transient; however, the loss of RNA led to a significant and sustained decrease in its protein abundance. …"

Image2_Arnica Montana L. Supercritical Extraction Optimization for Antibiotic and Anticancer Activity.JPEG حسب Taja Žitek (12521470)

"…The content of proanthocyanidins was highest at a pressure between 18 and 24 MPa. The extracts inhibited three different microorganisms successfully; Staphylococcus aureus, Escherichia coli and Candida albicans, at concentrations ranging from 0.1 to 5.16 mg/ml and showed anticancer activity decrease up to 85% at a concentration of 0.5 mg/ml.…"