Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases by Rui Li (4631)

“…Further, the AGA susceptibility alleles at the 17q21.31 locus are on the H1 haplotype, which is under negative selection in Europeans and has been linked to decreased fertility. Combining the risk alleles of six novel and two established susceptibility loci, we created a genotype risk score and tested its association with AGA in an additional sample. …”

Detection of apoptosis using flow cytometry. by Xi Fu (409609)

“…The arginine, homoarginine treatment significantly reduced the apoptosis of GA1 model cells, whereas the leucine and tyrosine treatment led to a slightly decrease in apoptosis that was not statistically significant. …”

Virus persistence quantification. by Margarita Pons-Salort (584738)

“…In order to study virus persistence, we defined the persistence index, <i>a</i>. For a given parameter set, we run the model 100 times and estimate <i>a</i> by fitting the function <i>f</i>(<i>t</i>) = <i>a</i>^{(0.01<i>t</i>)} to the decreasing proportion of simulations over time with virus persistence. …”

RNAIII regulates the levels of extracellular proteins at 6 h and 12 h. by Yu Liu (6938)

“…The results of SDS-PAGE showed that the extracellular proteins of <i>ΔRNAIII</i> were decreased in comparing with WT at 6 h and 12 h. 1,4,7: wild type; 2,5,8: <i>ΔRNAIII</i> (RNAIII deletion mutant); 3,6,9: ΔRNAIIIR (the restoration of RNAIII in <i>ΔRNAIII</i>). …”

Fluoride varnishes with calcium glycerophosphate: fluoride release and effect on in vitro enamel demineralization by Thiago Saads CARVALHO (5789396)

“…The results showed that both experimental varnishes released more fluoride than Duofluorid® and Duraphat® (p < 0.05), but Duraphat® showed the best preventive effect by decreasing enamel hardness loss (p < 0.05). Therefore, we conclude that even though (1) the experimental varnishes containing CaGP released greater amounts of F, (2) they did not increase in the preventive effect against enamel demineralization.…”

DataSheet1_Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways.docx by Karina S. MacDowell (10795161)

“…Expression of different proteins and the content of different metabolites involved in the function of serotonergic and kynurenine pathways was assessed by RT-PCR, immunoblot and ELISA analyses in frontal cortex of the offspring after puberty. MIA decreased tissue 5-HT content and promoted changes in the expression of serotonin transporter, 5-HT_2A and 5-HT_2C receptors. …”

Image2_Transcriptional regulation of Satb1 in mouse trophoblast stem cells.TIF by Wei Yu (43094)

“…Knockdown of ELF5 downregulated Satb1 expression in TS cells and overexpression of ELF5 increased the enhancer-reporter activity. …”

Image1_Transcriptional regulation of Satb1 in mouse trophoblast stem cells.TIF by Wei Yu (43094)

“…Knockdown of ELF5 downregulated Satb1 expression in TS cells and overexpression of ELF5 increased the enhancer-reporter activity. …”

DataSheet1_Transcriptional regulation of Satb1 in mouse trophoblast stem cells.PDF by Wei Yu (43094)

“…Knockdown of ELF5 downregulated Satb1 expression in TS cells and overexpression of ELF5 increased the enhancer-reporter activity. …”

DataSheet_2_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Table_1_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

DataSheet_3_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

DataSheet_1_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy by Nicole F. Liachko (669572)

“…In TDP-43 tg <i>C</i>. <i>elegans</i>, we conducted a genome-wide RNAi screen covering 16,767 <i>C</i>. …”

image_2_Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations.jpeg by Jéssica Barletto de Sousa Barros (5167421)

“…Of note, we found that higher levels of IP-10 and IL-5 in ZIKV-infected individuals were strongly associated with exanthema and headache, respectively. …”

Relationship between Age/Gender-Induced Survival Changes and the Magnitude of Inflammatory Activation and Organ Dysfunction in Post-Traumatic Sepsis by Susanne Drechsler (111514)

“…To compare general response patterns among groups, we calculated two scores: the inflammatory response (including KC, MIP-1α, TNFα, MCP-1, IFNγ, IL-1β,-5,-6,-10) and the organ dysfunction score (Urea, ALT, AST and LDH). …”

Extracellular Polymeric Substances (EPS) of Freshwater Biofilms Stabilize and Modify CeO₂ and Ag Nanoparticles by Alexandra Kroll (218239)

“…We extracted EPS from five different periphyton communities, characterized the extracts, and exposed CeO₂ and carbonate-stabilized Ag NP (0.5 and 5 mg/L, both 25 nm primary particle size) and AgNO₃ to EPS (10 mg/L) over two weeks. …”

image_1_Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations.jpeg by Jéssica Barletto de Sousa Barros (5167421)

“…Of note, we found that higher levels of IP-10 and IL-5 in ZIKV-infected individuals were strongly associated with exanthema and headache, respectively. …”

Large-scale analysis by SAGE reveals new mechanisms of oncogene action-4 by Corinne Bresson (73910)

“…The fold repression is represented, corresponding to a decrease of mRNA accumulation in T2ECs expressing the transforming form of v-ErbA (VA) in comparison with T2ECs expressing the non-transforming form of v-ErbA (NTVA). …”

Data_Sheet_1_Analysis of shared ceRNA networks and related-hub genes in rats with primary and secondary photoreceptor degeneration.ZIP by Jia Liang (2018293)

“…Immune cell infiltration and drug–gene interaction analyses were conducted, and hub gene expression was validated by quantitative real-time polymerase chain reaction (qRT-PCR).</p>Results<p>We identified 37 shared differentially expressed lncRNAs, 34 miRNAs, and 247 mRNAs and constructed a ceRNA network consisting of 3 lncRNAs, 5 miRNAs, and 109 mRNAs. …”