DataSheet1_Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach.pdf by Punyabhorn Rattanacheeworn (11447329)

“…AUC and C_max GMR (95%CI) of atorvastatin, another CYP3A substrate, was increased 2.14 (1.52–3.02) fold in healthy elderly and 4.15 (2.98–5.79) fold in elderly patients with CKD, indicating decreased CYP3A activity related to ageing. …”

A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice by Gemma Brufau (215229)

“…PS feeding resulted in a dose-dependent decrease of fractional cholesterol absorption (∼2–7-fold reduction) in wild-type mice and ∼80% reduction in Abcg5^-/- mice. …”

The levels of complex lipids are altered in the mitochondria of CPT1A^KD cells. by Cong-Hui Yao (2013793)

“…The diagonal line represents the equation <i>y</i> = <i>x</i>, so that points below the line represent the 66 lipids that decrease in abundance in CPT1A^KD cells. …”

African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells by Elena G. Sánchez (158471)

“…Inhibition of these key regulators of macropinocytosis, as well as treatment with the drug EIPA, results in a considerable decrease in ASFV entry and infection. …”

The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen by Betty Luong (5738027)

“…The accumulation of collagen was accompanied by a strong decrease of the expression and activity of the protease cathepsin B. …”

Urology Residents' Perspectives on the In-House On-Call Systems: A Study in an Accredited Academic Center by Khalil, Ibrahim A. and Ibrahim, Tarek and Aldeeb, Maya and Mohamed, Ahmed and Ben Salah, Rym and Aboumarzouk, Omar M. and Al-Naimi, Abdulla

“…Quality of life and education: We adopted a validated survey based on a 5-point Likert scale to assess the residents' perception of the transition to a 12-hour on-call system on their quality of life and education. …”
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A J-Like Protein Influences Fatty Acid Composition of Chloroplast Lipids in Arabidopsis by Imad Ajjawi (200926)

“…T-DNA mutants in the poorly annotated <em>Arabidopsis thaliana</em> gene At1g08640 were identified as containing moderately high levels (50–100%) of 16∶1Δ7 and 18∶1Δ9 leaf fatty acids and subtle decreases (5–30%) of 16∶3 and 18∶3 (<a href="http://www.plastid.msu.edu/">http://www.plastid.msu.edu/</a>). …”

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus by S.C.X. de-Almeida (6720584)

“…Indomethacin, used as reference, inhibited the paw edema by 59% at the same time-point. In the formalin test, FJNB inhibited the 1st phase by 27, 49, and 52% and the 2nd phase by 37, 50, and 67%, at the doses of 1, 5, and 10 mg/kg, respectively. …”

(A) Profile of mean-squared error of elastic-net regression for various values of lambda. by Chan C. Whiting (773096)

“…Thus, for example, the estimated age increases by approximately 1.6 years for every unit increase in absolute monocyte count (the analyte with the largest positive coefficient), holding all other values constant; and decreases by approximately 4.5 years for every unit increase in naïve CD8+ T cells (the analyte with the largest negative coefficient). …”

Effects of mismatched crRNAs on Cas12a-mediated phage defense. by Michael A. Schelling (15295682)

“…<p>(A) Schematic of crRNA expression and processing by FnCas12a and crRNA phage target locations. crRNA mismatches were introduced by mutating individual nucleotides in the spacer sequence. …”

Steady-state fluorescence studies provide additional support to the A region Model 3. by Sylvain Maenner (255271)

“…<p>In (A, B, and C), the binding sites of oligonucleotides P1 to P6 used in the FRET experiments are shown for the three 2-D structures of the A region corresponding to Models 1, 2, and 3. …”

Model response characteristics produced as a result of adjusting AMPA and NMDA conductance levels. by Cal F. Rabang (191595)

“…<p>Y-axis values correspond to AMPA conductance (0 – 20 nS), X-axis values correspond to ratio of NMDA to AMPA conductance (0, .5, 1, 1.5, 2, 2.5, 3). Values of AMPA conductance and NMDA:AMPA ratio chosen for Large and Small IC inputs are identified by a white L and S on the 100 ms color plots, respectively. …”

Lovastatin treatment results in actin disorganization and inhibits VEGF induced rhoA activation. by Tong T. Zhao (361937)

“…<p>A, Actin cytoskeletal organization was visualized using rhodamine-conjugated phalloidin following 24 hr 0.5, 2 and 5 µM lovastatin treatments of HUVEC. …”

<i>Coxiella burnetii</i> Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth by Dhritiman Samanta (8174058)

“…While endosomes progressively acidified from the periphery (pH~5.5) to the perinuclear area (pH~4.7) in both mock and Δ<i>dotA</i>-infected cells, endosomes did not acidify beyond pH~5.2 in WT-infected cells. …”

Conflicting selection pressures prevent the outgrowth of TIP-resistant HIV mutants in a host population. by Luke I. Rast (2735782)

“…For example, at <i>P</i> = 2.5, decreasing <i>η</i> results in major increases in transmission from TIP⁺ individuals (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004799#pcbi.1004799.g001" target="_blank">Fig 1B</a>) that overwhelm the modest decreases in transmission from TIP^- individuals, essentially removing the evolutionary conflict at the population-scale. …”

PrA conditioning reduced PBMC IP-10 secretion <i>in vitro</i>. by Maomao Zhang (393240)

“…The highest dose induced a significant decrease in viable cell count, therefore, only 5 nM and 20 nM concentrations were used in subsequent experiments. …”

Ligand-dependent stability of a 240 kDa protein can be probed by FASTpp. by David Minde (470117)

“…A gradual decrease in the band intensity at higher temperatures indicates unfolding. …”

Erratum: Natural Enamel Caries: A Comparative Histological Study on Biochemical Volumes by Barbosa de Sousa F. (4273123)

A COX inhibitor does not prevent the development of tactile allodynia after nerve injury. by Shigeo Hasegawa (249454)

“…The COX-1 inhibitor SC-560 (20 nmol/10 µl) administered through a catheter whose tip was positioned near the L5 DRG once daily for 14 days did not suppress the development of nerve injury-induced a decrease in the paw withdrawal threshold of tactile stimulation using von Frey filaments. …”

Single Molecule Nanospectroscopy Visualizes Proton-Transfer Processes within a Zeolite Crystal by Zoran Ristanović (1359162)

“…In this work, the Brønsted-acid-catalyzed oligomerization of styrene derivatives was used for the first time as a single molecule probe reaction to study the reactivity of individual zeolite H-ZSM-5 crystals in different zeolite framework, reactant and solvent environments. …”