Image_2_A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors.tif by James J. Harding (12415627)

“…Adult patients with treatment-refractory solid tumors received PF-06671008 (1.5–400 ng/kg) as a weekly intravenous (IV) infusion on a 21-day/3-week cycle. …”

Image_1_A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors.tif by James J. Harding (12415627)

“…Adult patients with treatment-refractory solid tumors received PF-06671008 (1.5–400 ng/kg) as a weekly intravenous (IV) infusion on a 21-day/3-week cycle. …”

AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability by Martina Di Rienzo (3901312)

Table_1_Dysregulation of Principal Circulating miRNAs in Non-human Primates Following Ischemic Stroke.XLSX by Jian Chen (15340)

“…For example, mml-miR-191-5p, miR-421, miR-409-5p, and let-7g-5p were found to be significantly overexpressed, whereas mml-miR-128a-5p_R − 2, miR-431_R − 1, and let-7g-3p_1ss22CT were significantly downregulated. …”

Influence of Ocean Acidification on a Natural Winter-to-Summer Plankton Succession: First Insights from a Long-Term Mesocosm Study Draw Attention to Periods of Low Nutrient Concent... by Lennart T. Bach (520701)

“…<div><p>Every year, the oceans absorb about 30% of anthropogenic carbon dioxide (CO₂) leading to a re-equilibration of the marine carbonate system and decreasing seawater pH. …”

Example of host protein coding transcripts significantly upregulated or downregulated in infected samples compared to mock infection. by Seth B. Garren (799962)

<i>Rab23</i> deletion perturbs ciliation in a context-dependent manner. by Wan Ying Leong (22075947)

“…<p><b>(A-B)</b> Representative immunohistochemistry images (low power on left, magnification of boxed region on right) and <b>(B)</b> graph depicting quantification of the proportion of Arl13b+ primary cilia against Tbr1+ (green) neocortical layer VI neurons in the neocortex at E18.5. …”

The effect of local climatic conditions on household consumption: a case study of South Africa by Calvin Mudzingiri (22188109)

“…The quadratic quantile regression model analysis shows that household per capita consumption is convex in precipitation. Below the turning point, increased precipitation is associated with decreased household per capita consumption. …”

Real time PCR in SSc-MVECs of <i>MACF</i>, <i>DIAPH1</i>, <i>DIAPH</i>2, <i>ARPC3</i>, <i>RAC2</i>, <i>CDH5</i>, and <i>ITGB8</i>. by Betti Giusti (74939)

Effects of the Pgp inhibitor tariquidar (TQ; 0.5 µM) in three functional assays, in which alterations in Pgp efflux are indirectly measured by determining intracellular concentrati... by Andreas Noack (519906)

Patterns of avian haemosporidian infections vary with time, but not habitat, in a fragmented Neotropical landscape by Juan Rivero de Aguilar (5917271)

“…We also found a temporal effect, with birds at the end of the five-month study (which ran from the end of the rainy season thru the dry season), being less infected by <i>Plasmodium</i> parasites than individuals sampled at the beginning. …”

Mutagenesis of the CXCL10 binding site on <i>L</i>. <i>(L</i>.<i>) major</i> GP63 to <i>L</i>. <i>(V</i>.<i>) panamensis</i> residues reduces CXCL10 cleavage and T cell chemotaxis. by Alejandro L. Antonia (7147739)

“…(L.) major gp63 <i>allele (D463) to the</i> L. (V.) panamensis <i>allele (N463) at the CXCL10 binding site decreases CXCR3</i>^<i>+</i> <i>T cell chemotaxis</i>. …”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice by Yanna Si (3234477)

“…Cognitive function was assessed 19 days later using a 5-day testing regimen with Morris water maze. …”

A 10-Year Trend Analysis of Heart Failure in the Less Developed Brazil by Amanda D. F. Fernandes (8618637)

“…Pearson correlation and linear-by-linear association test for trends were calculated, with a level of significance of 5%. Results: From 2008 to 2017, HF admissions decreased 62% (p = 0.004) in Paraiba and 34% (p = 0.004) in Brazil. …”

Supplementary Material for: Stair-Case/Honeycomb Maculopathy in Alport Syndrome: A Case Report by figshare admin karger (2628495)

“…Introduction: Alport syndrome is an inherited disease caused by mutations in COL4A5, COLA3, or COL4A4 resulting in kidney failure, hearing loss and ocular symptoms. …”

Transcriptional regulation of <i>AaERR</i> by EcR/USP bound to 20E. by Dan-Qian Geng (18137370)