Nuclear Glycolytic Enzyme Enolase of <i>Toxoplasma gondii</i> Functions as a Transcriptional Regulator by Thomas Mouveaux (226120)

“…Using a ChIP-Seq technique, we provide evidence for TgENO2 enrichment at the 5′ untranslated gene regions containing the putative promoters of 241 nuclear genes. …”

Data_Sheet_1_Functional characterization of Vibrio alginolyticus T3SS regulator ExsA and evaluation of its mutant as a live attenuated vaccine candidate in zebrafish (Danio rerio)... by Weijie Zhang (145595)

“…Type III secretion system (T3SS) is a crucial virulence mechanism of V. alginolyticus. …”

Primary tumour location affects survival after resection of colorectal liver metastases: A two-institutional cohort study with international validation, systematic meta-analysis an... by Elisabeth Gasser (6785981)

“…<div><p>Background</p><p>Colorectal cancer (CRC) represents a major cause for cancer death and every third patient develops liver metastases (CRLM). …”

The impact of a CTL-based vaccine is dependent upon the extent to which it affects transmission potential. by Helen R. Fryer (194033)

“…<p>This figure considers the impact that a five-epitope vaccine could have on an epidemic. …”

FoxO1a is induced by CD81 clustering, concurrent with deactivation of Akt. by Kuanyin K. Lin (200312)

“…<p>(A) The phosphorylation of Akt, an indicator of Akt activation, decreases upon CD81 clustering on proliferating HSCs. …”

Is urotherapy alone as effective as a combination of urotherapy and biofeedback in children with dysfunctional voiding? by Adem Altunkol (5912324)

“…Subsequently, biofeedback sessions were added for all patients, and the changes in the results were recorded and statistically compared. Results: A total of forty - five patients were included, of which 34 were female and 11 were male and the average age of the patients was 8.4 ± 2.44 years (range: 5 - 15 years). …”

<i>NDE1</i> plays a critical role in the action of binaphthoquinones. by Ashkan Emadi (248270)

“…Spot assays were performed in duplicate in two separate experiments with representative plates shown. (<i>B</i>) Decreased generation of ROS in the <i>nde1</i>Δ<i>nde2</i>Δ mutant following exposure to 5 µM BiQ7. …”

miR-29a modulates neuronal differentiation of MSCs by targeting REST. by Ping Duan (312653)

“…<p>(A) Lentiviral infection of miR-29a inhibitor decreases miR-29a expression in MSCs. …”

Effects of isobavachalcone treatment on BV-2 cells and Neuro-2a cells. by Haoran Jing (3621779)

“…C: Isobavachalcone decreased microglial-induced neuro-2a death in a co-culture system. …”

Description of the role of the pharmacist in a multiprofessional team focused on the care of hospitalized elderly by Isabela Vaz Leite Pinto (12817700)

“…A total of 163 pharmaceutical interventions were carried out, representing a mean of 6.79 interventions/patient and 82.2% acceptance. …”

Epidemiology of Orbital and Preseptal Cellulitis in the United States: A 13-Year Analysis by Shazia Dharssi (20563728)

“…Young adults (ages 21–44) comprise a majority of patients with either preseptal or orbital cellulitis (31.7%; 95% CI, 30.5–33.0%). …”

Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases by Xiaolong Liu (265696)

“…Partial responses were observed in cases 1 and 3, with some tumor shrinkage. Cases 4 and 5 showed limited relief following a slight decrease in tumor size. …”

Causal relationships between interleukins, interferons and COVID-19 risk: a Mendelian randomization study by Chao Wang (146527)

“…Finally, sensitivity analyses were applied to assess the robustness of results. As a result, one IFN (IFN-W1) and five ILs (IL-5, IL-6, IL-13, IL-16 and IL-37) were identified to significantly decrease the COVID-19 risk. …”

DataSheet_1_Reduced prevalence of drug-related problems in psychiatric inpatients after implementation of a pharmacist-supported computerized physician order entry system - a retro... by Katharina Wien (18330384)

“…To date, no study has been reported on the types and prevalence of drug-related problems (DRPs) before and after CPOE implementation in a psychiatric inpatient setting. The aim of this retrospective before-and-after cohort study was to investigate whether the implementation of a CPOE system with CDSS accompanied by the introduction of regular medication plausibility checks by a pharmacist led to a decrease of DRPs during hospitalization and unsolved DRPs at discharge in psychiatric inpatients.…”

B28Bn(6–14)-induced loss of mitochondrial transmembrane potential. A by Hao Yang (328526)

Data_sheet_1_Therapeutic effect of psilocybin in addiction: A systematic review.docx by Pim B. van der Meer (9606147)

“…In a pilot study (n = 10), the percentage of heavy drinking days decreased significantly between baseline and weeks 5–12 (mean difference of 26.0, 95% CI = 8.7–43.2, p = 0.008). …”

The representative trace of the LDF signal after the intravital injection of ADP to a mouse (a), parameters of the curve calculated by PAMA software, the LDU values are multiplied... by Tomasz Przygodzki (4277908)

“…<p>The following parameters characterizing the curve were calculated using PAMA software, as described in ‘<i>Materials and Methods</i>’ and are expressed in arbitrary Laser Doppler Flow units (LDU): <b>A</b>_<b>max</b><b>—</b>the maximum decrease in blood flow with respect to the baseline; <b>DA–</b>the maximal restoration of flow with respect to the baseline; <b>T</b>_<b>d</b><b>—</b>time from the injection of ADP to 10% of the maximum decrease in blood flow (A_max); <b>T</b>_<b>r</b><b>−</b>time from 10% to 90% of the maximum decrease in blood flow (A_max); <b>T</b>_<b>c</b><b>−</b>time from 90% of A_max to 90% of DA; <b>T</b>_<b>f</b><b>−</b>time from 90% of DA to 10% of DA; <b>V</b>_<b>0r</b><b>–</b>the maximal rate of the decrease in blood flow; <b>V</b>_<b>Avgr</b><b>−</b>the rate of decrease averaged through T_r; <b>V</b>_<b>0f</b><b>–</b>the maximal rate of the restoration of blood flow; <b>V</b>_<b>Avgf</b><b>−</b>the rate of restoration averaged through T_f; <b>AUC–</b>the area under the curve from 10% of A_max to 10% DA; <b>AUC</b>_<b>r</b><b>−</b>the area under the curve from 10% to 90% of A_max; <b>AUC</b>_<b>c</b><b>−</b>the area under the curve from 90% of A_max to 90% of DA; <b>AUC</b>_<b>f</b><b>−</b>the area over the curve from 90% to 10% of DA.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”