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5 points » 5 point (Expand Search), _ points (Expand Search), 3 points (Expand Search)
points decrease » point decrease (Expand Search), point increase (Expand Search)
wt decrease » we decrease (Expand Search), _ decrease (Expand Search), awd decreased (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
5 points » 5 point (Expand Search), _ points (Expand Search), 3 points (Expand Search)
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PKCε activation induces aggrecan gene expression, decreases ADAMTS5, and detection of ADAMTS-5-depended cleavage of ECM aggrecan through upregulation of hsa-miR-377 expression.
Published 2013“…<p>(<b>A</b>) RT-PCR detected the relative expression of ACAN, MKI67, ADAMTS5 after treatment of NP cells with 1 μM ψεRACK (or vehicle) for indicated times and revealed that time-dependent activation of PKCε significantly increased the mRNA expression for aggrecan, while in an opposing manner decreased ADAMTS5; mRNA levels of the proliferation marker Ki67 became barely detectable after 8 hours of PKCε activation. …”
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The <i>P[syt<sup>P-L</sup>]</i> mutation decreases the Ca<sup>2+</sup> affinity of release and vesicular release probability, but the readily releasable pool is unchanged.
Published 2017“…<p>(A) Mean EJP amplitudes from <i>+/-;P[syt<sup>WT</sup>]/+</i> (filled black circles) and <i>+/-;P[syt<sup>P-L</sup>]/+</i> (filled red circles) larvae at Ca<sup>2+</sup> levels ranging from 0.05 mM—5.0 mM. …”
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Decreased activity of FASII favors the cold growth of the <i>ΔcshA</i> strain.
Published 2020“…<i>fapR</i> mRNA levels were quantified by RT-qPCR using 16S rRNA as reference gene on total RNAs extracted from <i>wt</i> strain (PR01), <i>ΔcshA</i> strain (PR01-ΔcshA), and suppressor strains <i>ΔcshA/accC</i><sup><i>M385V</i></sup> (C51), <i>ΔcshA/accC</i><sup><i>T183I</i></sup> (sup30), <i>ΔcshA/accD</i><sup><i>F253V</i></sup> (sup17), <i>ΔcshA/accD</i><sup><i>A164V</i></sup> (sup16), <i>ΔcshA/birA</i><sup><i>D320F-FsX28</i></sup> (C58), <i>ΔcshA/birA</i><sup><i>R280stop</i></sup> (sup1) and <i>ΔcshA/bioY</i><sup><i>P123R-FsX1</i></sup> (C66), all at exponential growth phase in MH medium at 25°C. n = 5 for <i>ΔcshA</i>, <i>4 for wt</i> and 3 for all others. …”
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A R13A point mutation in C4 attenuates CLCuMuV infection.
Published 2018“…<b>(C)</b> The mutant CLCuMuV carrying C4<sup>R13A</sup> (CLCuMuV-C4<sup>R13A</sup>), which contains a R13A mutation in <i>C4</i>, showed the decreased viral symptom compared to wild type CLCuMuV. …”
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