Therapeutic targeting of the TPX2/TTK network in colorectal cancer by Hibah Shaath (5599658)

“…<h3>Background</h3><p dir="ltr">While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. …”

Exploring Beyond Numeric Weight Loss: The Metabolic Effects of Semaglutide. by Sara, Sokary

“…Also, it enhanced glycemic control, as evidenced by significant reductions in hemoglobin A1C (HbA1c) with the 0.5 mg and 1.0 mg doses. From a baseline range of 8.1–8.7%, 0.5mg dose lowered HbA1c by 1.2–1.5%, while the 1.0 mg dose reduced it by 1.4–1.8%. …”
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Theoretical and experimental insights into the C-steel aqueous corrosion inhibition at elevated temperatures in 1.0 M HCl via multi-carbonyl Gemini cationic surfactants by Nasser M. El-Basiony (18021631)

“…The Tafel polarization revealed that at 0.1 mM of LAPG and MAPG, the corrosion current density (i _corr) of CS was reduced to the lowest extent (75.56 and 53.82 μA cm⁻²) compared to 529.3 μA cm⁻² in the absence of the inhibitors. …”

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 by Abu Saleh Md Moin (6189512)

“…Two potent M1 macrophage activation markers, CXCL9 and CXCL10, were decreased in OT2D. …”

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis by Meritxell Espino‐Guarch (22565774)

“…Ex vivo incubation of LAT2KO muscle with rapamycin recovered proteolysis function, demonstrating a mTORC1‐dependent pathway. Decreased proteolysis in LAT2KO animals was associated with increased mTORC1 translocation to the lysosome (mTORC1‐Lamp1 colocalization in fasted LAT2KO muscles was 1.23‐fold, <i>p</i> < 0.0001). …”

The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polyc... by Thozhukat Sathyapalan (704787)

“…There was a significant positive correlation between ASP levels with CRP (p < 0.01), testosterone (p < 0.01) and HOMA-IR (p < 0.01); IL-6 levels with CRP (p <0.01) and testosterone (p < 0.01) and MCP-1 with CRP (p < 0.01); testosterone (p < 0.01) and HOMA-IR (p < 0.02).…”

Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis by Fateen Ata (12217764)

“…Patients with a 6-month DKA recurrence, female gender and T1DM had higher odds of 12-month recurrence, whereas a consult with a diabetes educator at the index admission was associated with decreased odds of recurrence.…”

Psychological and Coping Strategies Related to Home Isolation and Social Distancing in Children and Adolescents During the COVID-19 Pandemic: Cross-sectional Study by Abduljaleel Abdullatif Zainel (18055382)

“…Children and adolescents with intellectual disadvantages were excluded. A <i>P</i> value of .05 (two-tailed) was considered statistically significant.…”

The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) by Varghese P. Inchakalody (14557382)

“…The upregulation of Voltage-dependent anion-selective channel protein 1 (1.9-fold), Major vault protein (1.8-fold), Bax (1.16-fold), and Cytochrome C (1.39-fold) indicate the activation of the intrinsic pathway. …”

Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity by Mohammed R. Shaker (10316180)

“…In this study, we utilised human induced pluripotent stem cells (iPSCs) engineered with a doxycycline-inducible system to overexpress <i>KLOTHO</i> and generated 2D cortical neuron cultures from these cells. …”

The Triple “S” Impact of COVID-19: Nationwide Evidence of the Impact of the Stress Associated With Restrictive Measures on Substance Use, Sleep, and Social Connectedness in Qatar... by Muna Abed Alah (18171346)

“…Of tobacco users in our sample, 36% reported increased tobacco use since the start of home confinement, while 41.6% of alcohol users reported decreased alcohol use. Concerning sleep, 46.1% reported an increase in average sleep duration per day (0.77 h mean increase, 95% CI: 0.66-0.88, P<0.001), and a third of participants reported poorer sleep quality. …”

Impact of staying at home measures during COVID-19 pandemic on the lifestyle of Qatar’s population: Perceived changes in diet, physical activity, and body weight by Muna Abed Alah (14779534)

“…Participants reported increased sitting/reclining time (1.94 h/day mean increase), screen times (2.05 h/day mean increase) with p < 0.001, and decreased exercise time (0.11 h/day mean reduction) with p < 0.001. …”

From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease by Ahmad Raza (18205961)

“…Recently, novel therapies are emerging, including GLP-1 agonists, intranasal insulin, and mitochondrial antioxidants, that show surprising results for treating both conditions, but on the contrary, bioavailability and the timing of interventions remain a big challenge in the management of these diseases. …”

Machine Learning and Carbonate Reservoirs : A Production Data Perspective on Permeability Modelling by Mohamad Faysal Baalbaki (21547373)

“…It was noted that in cases where permeability increases from one well to another, the production data showed a decrease. …”

Comparative Genomic Mapping Implicates LRRK2 for Intellectual Disability and Autism at 12q12, and HDHD1, as Well as PNPLA4, for X-Linked Intellectual Disability at Xp22.31 by Jonathan D. J. Labonne (18090841)

“…<p dir="ltr">We report a genomic and phenotypic delineation for two chromosome regions with candidate genes for syndromic intellectual disability at 12q12 and Xp22.31, segregating independently in one family with four affected members. …”

Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature by Henry C. Ezechukwu (13253406)

“…We identified 45 studies reporting 1,280 human placentas that were analyzed by molecular pathology methods and 11,112 placenta-derived cells from a publicly available database that was analyzed using bioinformatics tools. …”

Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study by Stefanos Volianitis (22155835)

“…Hepatic glucose output increased from 0.6 (0.5–0.7) to 1.5 (1.3–1.7) mmol/min, while arterial lactate increased from 0.8 (0.7–0.9) to 9.0 (8.1–9.9) mmol/L (<i>P</i> < 0.05) despite a rise in hepatic lactate uptake. …”

Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts by Amr A. Fadle (14150298)

“…</p><h2>Other Information</h2> <p> Published in: International Orthopaedics<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00264-021-05041-1" target="_blank">http://dx.doi.org/10.1007/s00264-021-05041-1</a></p>…”

Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension by Thiruveni Ramkumar (17075051)

“…There was no significant difference in the mean initial blood glucose between neonates in the hypertensive versus non-hypertensive groups of mothers (1.7 vs 1.6 mmol/L). However, a sub-group comparison of neonates (with initial blood glucose <2.6 mmol/L) showed methyldopa to be marginally associated with a 2 mmol/L decrease from the mean initial blood glucose, mean 1.6 ± 0.5 mmol/L, and methyldopa (1.4 ± 0.5 mmol/L; p= .045). …”

Characterization of Electronic and Ionic Transport in Li_1-_<em>x</em>Ni_0.33Mn_0.33Co_0.33O₂(NMC₃₃₃) and Li... by Ruhul Amin (2113627)

“…The lithium ion diffusivity is at least one order of magnitude lower, and decreases with increasing <i>x</i> to at <i>x</i> = ∼0.5. …”