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Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice
منشور في 2023"…<p dir="ltr">Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. …"
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103
Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
منشور في 2018"…Here, we provide a review of the EBV epidemiology and the genetic variability of the oncogene LMP-1. …"
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104
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation
منشور في 2013"…We observed ATP depletion under OGD vs. hypoxia and propose that ATP depletion enhances translational suppression, overcoming the selective synthesis of HIF concurrent with global decreases in protein synthesis in hypoxia. Taken together, these findings biochemically characterize a practical reporter for monitoring HIF-1α levels and support a novel model for HIF regulation in an in vitro model of human ischemia.…"
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105
PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
منشور في 2019"…<p>Tumor progression through immune evasion is a major challenge in cancer therapy. Recent studies revealed that enhanced PD-L1 expression in cancer stem cells is linked to immune evasion. …"
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106
The contribution of autophagy in glioblastoma multiforme cells treated with human recombinant arginase I-induced arginine deprivation. (c2018)
منشور في 2018"…Moreover, it is resistant to traditional chemotherapies and radiotherapies. All this results in a poor survival rate in GBM patients, which doesn’t exceed 1 year. …"
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107
Secrecy Performance of a RIS-Assisted Wireless Network: A Comprehensive Analysis Under Outdated CSI
منشور في 2025"…Moreover, increasing the number of REs can mitigate CSI aging effects where an SOP level of 3×10<sup>−5</sup> can be achieved with 140 REs at <i>ρ</i>=0.9 in the absence of a transmitter-receiver direct link. …"
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Women’s empowerment as a determinant of neonatal mortality in Sub-Saharan Africa: a narrative review focused on Nigeria
منشور في 2024"…</p><h2>Other Information</h2><p dir="ltr">Published in: Global Health Action<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/16549716.2024.2394256" target="_blank">https://dx.doi.org/10.1080/16549716.2024.2394256</a></p>…"
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
منشور في 2017"…This absence of caspase activation was confirmed by a 72 hours cytotoxicity assay on Panc-1 cells, which revealed the failure of the pan-caspase inhibitor, Z-VAD, to reverse or decrease arginine depletion-triggered cell death. …"
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masterThesis -
110
Origin of arrhythmias in a heart model
منشور في 2009"…An investigation of the nonlinear dynamics of a heart model is presented. The model compartmentalizes the heart into one part that beats autonomously (the x oscillator), representing the pacemaker or SA node, and a second part that beats only if excited by a signal originating outside itself (the y oscillator), representing typical cardiac tissue. …"
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111
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A Numerical Study of Heat Transfer and Fluid Flow in a Channel with an Array of Pin Fins in Aligned and Staggered Configurations
منشور في 2018"…Fin array configurations with large spacing ratio, S*, showed a better performance than smaller spacing ones. …"
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113
Wales’ tourists not a burden for local healthcare
منشور في 2016"…</i></p><p></p><h2>Other Information</h2><p>Published in: QScience.com Highlights, Published by Nature Research for Hamad bin Khalifa University Press (HBKU Press)<br>License: <a>http://creativecommons.org/licenses/by/4.0</a><br></p>…"
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114
A clustering metaheuristic for large orienteering problems
منشور في 2022"…</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0271751" target="_blank">https://dx.doi.org/10.1371/journal.pone.0271751</a></p>…"
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115
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When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
منشور في 2021"…Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. …"
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117
Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis
منشور في 2025"…</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: European Journal of Trauma and Emergency Surgery<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00068-025-03033-z" target="_blank">https://dx.doi.org/10.1007/s00068-025-03033-z</a></p>…"
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118
Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
منشور في 2025"…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…"
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119
Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
منشور في 2021"…<h3>Introduction</h3><p dir="ltr">Neuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). …"
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