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Genetic Deletion of DNAJB3 Using CRISPR-Cas9, Produced Discordant Phenotypes
منشور في 2023"…Three DNAJB3 knockout (KO) lines were generated (KO 30, 44 and 47), using CRISPR-Cas9. Male and female KO and WT mice were fed a HF diet (45% kcal fat) for 16 weeks. …"
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Thermoelectric power of (Cu0.5Tl0.5)-1223 superconducting phase added with BaSnO3 nanoparticles
منشور في 2017"…Superconducting transition temperature (Tc) increases up to 117.5 for x = 0.25 wt.% and then it decreases with further x addition. …"
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Durability of Cardiometabolic Outcomes Among Adolescents After Sleeve Gastrectomy: First Study with 9-Year Follow-up
منشور في 2022"…The preoperative mean body mass index (BMI) (45.60 ± 6.50 kg/m2) decreased at year 1 (30.04 ± 4.96 kg/m2, P=0.001) and was maintained up to 9 years (30.20 ± 3.92 kg/m2, P = 0.001). …"
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Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained?
منشور في 2025"…Mean HbA1c significantly decreased from 8.1%preop to 6.77%<sub>year 9</sub>. …"
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LDL-C Targets in Secondary Prevention: How Low Should We Go?
منشور في 2019"…The concern for adverse effects with very low LDL-C levels is not backed by the literature, and side effects appear to be medication-specific. There still remains a question of the cost-effectiveness of some non-statin therapies particularly PCSK9 inhibitors, in spite of recent price decreases, and whether the benefit is worth the cost.…"
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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
منشور في 2021"…However, 4-hours post-hypoglycemia, sNRP1, VEGF and ADAM9 were elevated in T2D(p<0.05). SEMA3A was not different at baseline; at hypoglycemia, SEMA3A decreased in controls only. …"
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SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines
منشور في 2024"…Notably, omicron infection showed reduced overall ADCC activity compared to WT SARS‐CoV‐2 infection. Although post‐mRNA vaccination BTI elicited high levels of binding and NAbs, ADCC activity was significantly reduced. …"
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Therapeutic targeting of the TPX2/TTK network in colorectal cancer
منشور في 2023"…<h3>Background</h3><p dir="ltr">While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. …"
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A customised fetal growth and birthweight standard for Qatar: a population-based cohort study
منشور في 2024"…The main pathological factors were preexisting diabetes (increase by +175.7 g) and smoking (decrease by −190.9 g). The SGA and LGA rates in the entire cohort after applying the population-specific customized centiles were 11.1 and 12.2 %, respectively (contrasting with the Hadlock standard: SGA-26.3 % and LGA-1.8 %, and Fenton standard: SGA-12.9 % and LGA-4.0 %).…"
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A Modification to Enhance the Survival of the Island FDMA Flap by Adding a Skin Bridge
منشور في 2021"…We combined Foucher and Holevich characteristics to design a flap that promises to solve the problem.</p><h3>Methods</h3><p dir="ltr">This is a case series that includes 9 patients where we describe a technique that has the potential to enhance the survival of the first dorsal metacarpal artery (FDMA) flap and decreases the rate of distal necrosis via addition of a 5-mm skin bridge to the pedicle and by avoiding tunneling. …"
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Secrecy Performance of a RIS-Assisted Wireless Network: A Comprehensive Analysis Under Outdated CSI
منشور في 2025"…Moreover, increasing the number of REs can mitigate CSI aging effects where an SOP level of 3×10<sup>−5</sup> can be achieved with 140 REs at <i>ρ</i>=0.9 in the absence of a transmitter-receiver direct link. …"
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MHD Heat Transfer Enhancement in a Curvilinear Enclosure With Oscillating Wall and Nano‐Encapsulated PCM: A Fluid‐Structure Interaction Analysis
منشور في 2025"…Using finite element methodology with specialized treatment for moving boundaries, we evaluate key parameters: Rayleigh number (<i>Ra</i>: 10³–10⁵), Stefan number (<i>Ste</i>: 0.1–0.9), phase transition temperature (θf: 0.1–0.9), NEPCM concentration (ϕ: 0.01–0.04), oscillation amplitude (<i>A:</i> 0.01–0.15), Hartmann number (<i>Ha</i>: 0–20), and magnetic field angle (<i>γ</i>: 0°–90°). …"
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The promise of tirzepatide: A narrative review of metabolic benefits
منشور في 2025"…Tirzepatide administration for 72 weeks elicited significant weight reduction ranging from 5 % to 20.9 % across different trials in a dose-dependent manner. …"
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Carotid artery revascularization through a radiated field
منشور في 2003"…Radiation-induced accelerated atherosclerosis has been recognized for some time.1, 2, 3 and 4 Because of the prolonged survival of patients treated with radiation,5 the frequency of this long-term side effect is expected to increase. In a prospective study, late (>70%) carotid artery stenosis was found in 11.7% of 240 patients who had undergone cervical irradiation.6 The chronic effects of radiation therapy lead to decreased vascularity and increased fibrosis, which in turn lead to risk for tissue necrosis, infection, and ulceration. …"
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Removal of nitrate from JUST wastewater effluent: a case study
منشور في 2013احصل على النص الكامل
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A Multidecadal Assessment of Haze Development and Fluctuations in Visibility for Arabian Peninsula
منشور في 2024"…</p><h2>Other Information</h2><p dir="ltr">Published in: Earth Systems and Environment<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s41748-024-00531-9" target="_blank">https://dx.doi.org/10.1007/s41748-024-00531-9</a></p>…"