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P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis
Published 2010“…Consistent with this, P-gp function was also increased by 1.5-fold and riluzole brain disposition was decreased by 1.7-fold in mSOD1 mice. …”
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Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis
Published 2025“…</p><h3>Results</h3><p dir="ltr">LAT2KO mice experienced a notable reduction in body weight during fasting (WT:14% and LAT2KO:18%, <i>p</i> = 0.02), with a greater reduction in fat mass (0.5‐fold, <i>p</i> = 0.013) and a higher relative retention of muscle mass (1.3‐fold, <i>p</i> = 0.0003) compared with WT. …”
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Effect of temperature on the rheological properties of neat aqueous Wyoming sodium bentonite dispersions
Published 2017“…The yield stress increased linearly with temperature by almost three-fold, the flow consistency index decreased exponentially with temperature by almost five-fold and the flow behavior index increased by about 20%, tending towards the Newtonian value. …”
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
Published 2022“…Thus, according to Drug Reduction Index (DRI), a combination of 6-fold less concentration of cisplatin with 1.3-fold less concentration of CBD yields a 95% cell growth inhibition. …”
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masterThesis -
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Retinal imaging based glaucoma detection using modified pelican optimization based extreme learning machine
Published 2024“…The effectiveness has been evaluated using two standard datasets called G1020 and ORIGA with the $$10 \times 5$$-fold stratified cross-validation technique to ensure reliable evaluation. …”
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Surgical Strategies for Synchronous Colorectal Liver Metastases in 156 Consecutive Patients
Published 2015“…The main limitation of this strategy is that it can be offered only in selected patients with synchronous disease,5, 6, 7, 8, 9 and 10 and it is associated with an increased risk of postoperative complications when major liver resection is combined with resection of the primary tumor.11, 12 and 13 Recently, a “reverse strategy,” in which preoperative chemotherapy is followed by resection of the CLM and then by resection of the colorectal primary at a second operation, has been proposed for patients with advanced synchronous CLM, and in particular, for patients in whom the primary is located in the rectum.14 The rationale for the reverse strategy is 2-fold: primary-related complications (such as bleeding, obstruction, or perforation) are rare in patients with stage IV colorectal cancer receiving combination chemotherapy15 and 16 and treatment of the metastatic disease is not delayed by local therapy for the primary tumor (surgery, and in the case of rectal cancer, radiotherapy or radiochemotherapy) or by complications of surgical treatment of the primary tumor. …”
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The downsides of information systems security policy compliance efforts
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masterThesis -
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Subsarcolemmal cAMP signals monitored by cyclic nucleotide gated channels in hypertrophied cardiac myocytes
Published 2005“…Cumulative concentrationresponse curve to the non-selective E-adrenergic agonist isoprenaline (Iso) indicated a 33% decrease of the maximal cAMP accumulation produced by Iso while the effect of the hydrosoluble forskolin analog, L-858051 at a saturating concentration (100 µM) was unchanged between the two groups. …”
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Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats
Published 2017“…Diabetic rats were injected intraperitoneally with 0.03 μg exendin-4/kg body weight/daily or treated with 5 ppm selenium in drinking water for a period of 4 weeks. …”
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Performance of Membrane Biological Reactor for Tobacco Wastewater Treatment
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doctoralThesis -
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Breaking the barriers towards large-scale microalgae-based bio-hydrogen production
Published 2025“…Integration levers show tangible gains: secondary-treated wastewater enabled <i>Chlorella</i> growth with 76 % NH<sub>4</sub>+ removal and 53 % lipid accumulation; the spent medium yielded 200.8 μmolH<sub>2</sub>/mg<sub>chlorophyll.a</sub> in cyanobacteria; swine-wastewater loops cut freshwater use six-fold with 45.5 mLH<sub>2</sub>/gVS; alginate immobilization raised H<sub>2</sub> ∼40 % (to 2.4 LH<sub>2</sub>/<sub>Lculture</sub>) over five reuse cycles. …”
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Salicylic acid restricts mercury translocation by activating strong antioxidant defense mechanisms in sweet pepper (Capsicum annum L.)
Published 2023“…Spraying of 100 μ M SA at three different Hg levels, i.e., 0 μ M, 50 μ M, 100 μ M, and 150 μ M. The maximum decrease in photosynthetic machinery, plant growth attributes (shoot length, root length, no. of leaves, fresh and dry biomass (shoot and root)), and more accumulation of Hg in leaves, roots, and fruits of sweet pepper. …”
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Effects of selenium in comparison to exendin-4 on the expression of GLP-1R, IRS-1 and preproinsulin in the pancreas of diabetic rats
Published 2016“…Diabetic rats were injected intraperitonially with 0.03 μg exendin-4/kg body weight/daily or treated with 5 ppm selenium in drinking water for a period of 4 weeks. …”
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