Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans حسب Kevin S. Chen (9201767)

"…We then used genetic and pharmacological methods to define the features of early motor dysfunction of α-synuclein-expressing C. elegans. …"

Trends in criminal convictions in Japan for vehicle collisions where one driver suffers from an epileptic seizure حسب Mineko Baba (19774386)

"…We used databases of five nationwide newspapers (Asahi, Mainichi, Nikkei, Sankei, Yomiuri). …"

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal... حسب Haidong Wang (47381)

"…Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. …"

Orofacial Clefts حسب El Baba, Nada

"…We aimed to investigate the genetic and molecular basis underlying a case of non-syndromic cleft lip/palate. To do so, we extracted primary cells from a cleft patient and primary cells from a healthy individual. …"
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LDL-C Targets in Secondary Prevention: How Low Should We Go? حسب Karim Bayoumy (3496688)

"…The concern for adverse effects with very low LDL-C levels is not backed by the literature, and side effects appear to be medication-specific. There still remains a question of the cost-effectiveness of some non-statin therapies particularly PCSK9 inhibitors, in spite of recent price decreases, and whether the benefit is worth the cost.…"

The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polyc... حسب Thozhukat Sathyapalan (704787)

"…</p><h3>Results</h3><p dir="ltr">There was significant reduction in ASP (156.7 ± 16.2 vs. 124.4 ± 14.8 ng/ml p <0.01), IL-6 (1.48 ± 0.29 vs.0.73 ± 0.34 pg/ml p = 0.01) and MCP-1 (30.4 ± 4.2 vs. 23.0 ± 4.5 pg/ml p = 0.02) after 12 weeks of atorvastatin that was maintained subsequently with 12 weeks treatment with metformin. …"

The immune landscape of solid pediatric tumors حسب Shimaa Sherif (12862990)

"…</p><h3>Methods</h3><p dir="ltr">We performed a systematic analysis of public RNAseq data (TARGET) for five pediatric tumor types (408 patients): Wilms tumor (WLM), neuroblastoma (NBL), osteosarcoma (OS), clear cell sarcoma of the kidney (CCSK) and rhabdoid tumor of the kidney (RT). …"

Assessing the Built Environment’s Reflectivity, Flexibility, Resourcefulness, and Rapidity Resilience Qualities against Climate Change Impacts from the Perspective of Different Sta... حسب Mohammed M. Al-Humaiqani (18325554)

"…In this study, various stakeholders were engaged, including governmental authorities, regulatory bodies, engineering firms, professionals, contractors, and non-governmental and non-profit organizations (NGOs and NPOs, respectively). …"

NLRP7 inter-domain interactions حسب El Maarri, Osman

"…In order to better understand how the effects of HYDM1 are associated with mutations on the structure of NLRP7, we performed an inter-domain interaction screen using a yeast two-hybrid system. Additionally, we generated in silico structural models of NLRP7 in its non-activated and activated forms. …"
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Essays on international environmental policy حسب Marrouch, Walid

"…My essay, investigates one possible market-based remedy to this problem, namely a "spatial" tax on farming activities which decreases as such activities take place farther upstream away from the population center. …"
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Preparation of albumin-targeted liposomes and the study of their release characteristics using ultrasound حسب Turki, Renad

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Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 حسب Natalie C Galles (9715361)

"…The global number of zero-dose children fell by nearly 75% between 1980 and 2019, from 56·8 million (52·6–60·9) to 14·5 million (13·4–15·9). However, over the past decade, global vaccine coverage broadly plateaued; 94 countries and territories recorded decreasing DTP3 coverage since 2010. …"

Protein and pH-dependent Binding of Nascent Pectin and Glucuronarabinoxylan to Xylogucan in Pea حسب Rizk, Sandra

"… Nascent pectin and glucuronoarabinoxylan, synthesised in vitro by membrane-bound enzymes from etiolated pea (Pisum sativum L.) epicotyls, were found to bind to pea xyloglucan in a pH-dependent manner. The binding was maximum at low pH (3–4), and decreased to almost zero at pH 6. …"
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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... حسب Michael, Brauer

"…From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. …"
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Experimental Investigation of FRP-Reinforced Concrete Columns Under Concentric and Eccentric Loading حسب Elmesalami, Nouran Zinelabdin Ahmed

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Rising mortality related to cardiovascular disease and prostate cancer amongst older men across the United States حسب Abdul Ahad (545575)

"…</p><h3>Conclusion</h3><p dir="ltr">After decreasing death rates associated with CVD and PCa from 1999 to 2015, a reversal in the trend was observed from 2015 to 2019. …"

Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease حسب Satra Nim (11540447)

Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Stud... حسب Robert C Reiner (5147636)

"…Findings The greatest declines in diarrhoeal mortality were seen in south and southeast Asia and South America, where 54·0% (95% uncertainty interval [UI] 38·1–65·8), 17·4% (7·7–28·4), and 59·5% (34·2–86·9) of units, respectively, recorded decreases in deaths from diarrhoea greater than 10%. …"

An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School حسب AL AHMAD, ALAAEDDIN MEHY

"…Given the high number of British as well as other non-Arabic schools in Dubai, this is a significant issue as many Arabic-speaking students are failing to achieve proficiency in their native language. …"
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Understanding the phenomenon of saltwater intrusion sourced from desalination plants at coastal aquifers حسب Farhat Abbas (5480)

"…The objective was achieved by optimizing non-measurable solute transport parameters from an existing set of data generated from a series of logical miscible displacements of potassium bromide through sepiolite minerals and curve-fitting simulations. …"