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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…<p dir="ltr">In somatic cells/tissues, methylation of ribosomal DNA (rDNA) increases with age and age‐related pathologies, which has a direct impact on the regulation of nucleolar activity and cellular metabolism. …”
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The effect of sperm DNA fragmentation on intracytoplasmic sperm injection outcome
Published 2021“…This cohort reported that the clinical reproductive outcomes of intracytoplasmic sperm injection showed no statistical significance with increase sperm DNA fragmentation levels. In sperm DNA fragmentation above 30%, favourable females had significantly higher clinical pregnancy rate and live birth rate than unfavourable females, while fertilisation rate and miscarriage rate showed no significance between the subgroups. …”
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Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone
Published 2022“…However, associations between DNA methylation profiles and disease severity of PDB have not been investigated.…”
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Published 2023“…<h3>Background</h3><p dir="ltr">Lack of Schlafen family member 11 (SLFN11) expression has been recently identified as a dominant genomic determinant of response to DNA damaging agents in numerous cancer types. Thus, several strategies aimed at increasing SLFN11 are explored to restore chemosensitivity of refractory cancers. …”
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DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Published 2000“…However, when cells were incubated with 10 μg/ml free DOX for up to 9 h, DNA damage increased with incubation time (P=0.0011). …”
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DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome
Published 2022“…COVID-19 patients were followed at four time points for 60 days. DNA methylation and immune cell populations were measured at each time point. …”
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mtDNA lineages reveal coronary artery disease‐associated structures in the Lebanese population
Published 2011“…This study investigates associations of Lebanese mitochondrial DNA lineages with CAD and studies their correlation with other populations, exploring population structures that may infer mitochondria functional associations and reveal population movements and origins. …”
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Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor—An Opportunity for Cancer Treatment
Published 2019“…From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. …”
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Maternal–Neonatal Methylome Signatures In Preterm Birth Revealed By Long-Read DNA Methylation Profiling
Published 2025“…Epigenetic regulation, particularly DNA methylation, is increasingly recognized as a key mediator of these processes, yet dual maternal-neonatal methylation landscapes in PTB remain insufficiently characterized. …”
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Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents
Published 2020“…Cytotoxicity assays on A375 showed a mean phototoxicity index of 340 at 72 hours, presenting the intracellular aquated photoproducts being effective rather than the dissociating ligands. A significant increase in ROS production and DNA damage was also observed. …”
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Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage
Published 2018“…SFN delayed senescence by decreasing glucose metabolism on the approach to senescence, exhibiting a caloric restriction mimetic-like activity and thereby decreased oxidative damage to cell protein and DNA. This was associated with increased expression of thioredoxin-interacting protein, curbing entry of glucose into cells; decreased hexokinase-2, curbing entry of glucose into cellular metabolism; decreased 6-phosphofructo-2-kinase, downregulating formation of allosteric enhancer of glycolysis fructose-2,6-bisphosphate; and increased glucose-6-phosphate dehydrogenase, downregulating carbohydrate response element- (ChRE-) mediated transcriptional enhancement of glycolysis by Mondo/Mlx. …”
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Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls
Published 2019“…<p dir="ltr">Mitochondrial diseases arise due to defects in mitochondrial DNA (mtDNA) or nuclear mitochondrial genes (nDNA), leading to impaired mitochondrial oxidative phosphorylation and dysfunction of organs with particularly high energy requirements. …”
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Review of field methods for monitoring Asian bears
Published 2022“…Many Asian bear population assessments have relied on expert opinion, local interviews, and sign surveys to provide estimates of distribution, abundance, and trend, in part because these are inexpensive and relatively easy to employ. However, increasing use of camera traps and DNA-based methods now allow for better monitoring via occupancy or rigorous capture–recapture population estimation, with the caveat that these methods may be restricted by inadequate budgets or logistical constraints. …”
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Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy
Published 2021“…Silencing LDHC in four breast cancer cell lines significantly increased the presence of giant cells, nuclear aberrations, DNA damage, and apoptosis. …”
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Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer
Published 2020“…<h3>Background</h3><p dir="ltr">Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. …”
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Yeast Lacking the PP2A Phosphatase Regulatory Subunit Rts1 Sensitizes rad51 Mutants to Specific DNA Damaging Agents
Published 2019“…We further show that Rts1 has the ability to bind to DNA and in its absence cells displayed an increase in the frequency of both spontaneous and bleomycin-induced mutations compared to the parent. …”
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Rfg1, a protein related to the hypoxic repressor Rox1 of Saccharomyces cerevisiae, is a novel DNA binding repressor of filamentation in the pathogenic yeast, Candida albicans
Published 2001“…Rox1 is an HMG-domain, DNA binding protein with a repression domain that recruits the Tup1/Ssn6 general repression complex to achieve repression. …”
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masterThesis
