Search alternatives:
ppm decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
n decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
15 nm » 15 n (Expand Search), 5 nm (Expand Search), 10 nm (Expand Search)
5 n » 15 n (Expand Search), 5 nm (Expand Search)
ppm decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
n decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
15 nm » 15 n (Expand Search), 5 nm (Expand Search), 10 nm (Expand Search)
5 n » 15 n (Expand Search), 5 nm (Expand Search)
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
Published 2021“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
Published 2021“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”
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Scenario (6): Parameter variation (50% decrease)—With 5 N.m load applied at t = 0.3s.
Published 2023“…<p>Scenario (6): Parameter variation (50% decrease)—With 5 N.m load applied at t = 0.3s.</p>…”
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