First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

FTY720 decreased viability, proliferation, and motility and induced apoptosis in human hepatoblastoma cells. by Laura L. Stafman (6577184)

“…<p>(A) Following 24 hours of treatment with FTY720, the viability of HuH6 cells measured using the alamarBlue cell viability assay was significantly decreased (LD₅₀ = 8.4 μM, p ≤ 0.05). …”

E₅₀ values. by Junxia Zhou (14381598)

Predicting pattern diversity decreases as a function of and . by Selim Haj Ali (21222613)

“…(a) and (b): Average negative predictive value for and , respectively for and . …”

S3 File - by Abdullah Niaz (16955618)

“…At higher concentrations some desorption was observed (36% at 50 ppm) but was reduced at lower concentrations (1–3% at < 5 ppm). …”

S1 File - by Abdullah Niaz (16955618)

“…At higher concentrations some desorption was observed (36% at 50 ppm) but was reduced at lower concentrations (1–3% at < 5 ppm). …”

Key properties of MCPA. by Abdullah Niaz (16955618)

“…At higher concentrations some desorption was observed (36% at 50 ppm) but was reduced at lower concentrations (1–3% at < 5 ppm). …”

S2 File - by Abdullah Niaz (16955618)

“…At higher concentrations some desorption was observed (36% at 50 ppm) but was reduced at lower concentrations (1–3% at < 5 ppm). …”

Minimum quorum sensing inhibitory concentrations (MQSICs), minimum inhibitory concentrations (MICs), and concentrations inhibiting 50% of violacein production (IC50s) of compounds... by Jean Paul Dzoyem (6424445)

Subjects:

The fraction of predicted heterozygotes that are set to “No Call” by RHA decreases as the size of the heterozygote cluster increases. by Orna Mizrahi-Man (42539)

EQI decreases malonyl-CoA levels in <i>S</i>. <i>aureus</i>. by Erica C. Larson (1344687)

Test characteristics for identifying stenosis ≥ 50% in any limb from aorta till popliteal artery in the overall population (<i>n = 126 limbs</i>). by O. Stivalet (6890189)

TEMPO-Oxidized Microcrystalline Cellulose for Rapid Adsorption of Ammonium by Jia Hui Ong (12085606)

“…The adsorption performance of the material was minimally influenced by a pH range of 5.0–9.0 but substantially affected by the presence of competing ions. …”

Dose response of airways to Methacholine shows a decreased contractility in <i>GSTCD</i>^-/- mouse lungs following LPS treatment. by Bo Liu (127343)

E₅₀ values of angle. by Junxia Zhou (14381598)

Curve fitting of E₅₀. by Junxia Zhou (14381598)

Fitting curves of E₅₀. by Junxia Zhou (14381598)

E₅₀ values of size. by Junxia Zhou (14381598)

E₅₀ fluctuation coefficient. by Junxia Zhou (14381598)