Showing 61 - 80 results of 8,224 for search '(( 5 ppm decrease ) OR ((( 50 mg decrease ) OR ( 50 we decrease ))))', query time: 0.64s Refine Results
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    Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

    Published 2021
    “…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC<sub>50</sub> 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”
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    XRD diffraction pattern spectra of PFAgNPs. by Kenedy Kiyimba (9942393)

    Published 2025
    “…The no observed adverse effect level was 50mg/kgBW, the lowest observed adverse effect level was 100 mg/kgBW, and median lethal dose (LD<sub>50</sub>) was 1000 mg/kg. …”
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    Raw data. by Adrian Bartoszek (20826922)

    Published 2025
    “…In the PTZ-induced seizure model, the application of CAF in doses over 50mg/L resulted in a decrease in the average movement. …”
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