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50 ng » 50 mg (Expand Search), 10 ng (Expand Search), 5 ng (Expand Search)
5 wt » _ wt (Expand Search), 5 ht (Expand Search)
ppm decrease » _ decrease (Expand Search), a decrease (Expand Search), nn decrease (Expand Search)
ng decrease » nn decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
wt decrease » we decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
w decrease » we decrease (Expand Search), _ decrease (Expand Search), a decrease (Expand Search)
50 ng » 50 mg (Expand Search), 10 ng (Expand Search), 5 ng (Expand Search)
5 wt » _ wt (Expand Search), 5 ht (Expand Search)
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Image_1_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2023“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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Image_1_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2022“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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Image_2_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2023“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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Image_3_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpg
Published 2022“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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Image_3_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpg
Published 2023“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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Image_2_Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.jpeg
Published 2022“…The trabecular bone volume over total volume (BV/TV) in J<sub>H</sub><sup>-/-</sup> mice was similar to WT mice at all ages. In contrast, at six months of age and thereafter, λ5<sup>-/-</sup> and J<sub>H</sub><sup>-/-</sup>λ5<sup>-/-</sup> mice demonstrated a severe decrease in trabecular bone mass. …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(C-D) GlcCer levels in the brain (C) and liver (D) are unchanged in het <i>GBA1</i> D409V KI mice as compared to WT mice at 5 months of age. …”
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