Cytotoxicity assay. by Rodrigo Rollin-Pinheiro (239450)

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Cytotoxicity assay. by Rodrigo Rollin-Pinheiro (239450)

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Antifungal activity of alexidine, amorolfine, olorofim, voriconazole and caspofungin—alone and in combinations according to fractional inhibitory concentration index (FICI)—against... by Rodrigo Rollin-Pinheiro (239450)

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Identification of the selected compounds from the screening of the Pandemic Response Box^® library. by Rodrigo Rollin-Pinheiro (239450)

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Preformed biofilm. by Rodrigo Rollin-Pinheiro (239450)

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Effect of alexidine, amorolfine and olorofim on preformed biofilms of <i>Scedosporium</i> and <i>Lomentospora</i> species. by Rodrigo Rollin-Pinheiro (239450)

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Minimum inhibitory concentration of alexidine, amorolfine, olorofim and voriconazole against several <i>Scedosporium</i> and <i>Lomentospora</i> species. by Rodrigo Rollin-Pinheiro (239450)

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Alterations on <i>S</i>. <i>aurantiacum</i> cells. by Rodrigo Rollin-Pinheiro (239450)

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Antifungal activity of alexidine, amorolfine, olorofim, voriconazole and caspofungin—alone and in combinations according to the Bliss independence model. by Rodrigo Rollin-Pinheiro (239450)

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Effect of alexidine, amorolfine and olorofim on biofilm formation of <i>Scedosporium</i> and <i>Lomentospora</i> species. by Rodrigo Rollin-Pinheiro (239450)

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Morphological alterations on <i>S</i>. <i>aurantiacum</i> biofilm by scanning electron microscopy. by Rodrigo Rollin-Pinheiro (239450)

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Pandemic Response Box library screening data. by Rodrigo Rollin-Pinheiro (239450)

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Biofilm formation. by Rodrigo Rollin-Pinheiro (239450)

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LD- and haplotype-based measures of epistasis identify a narrow time window of epistasis detectability. by Gabriele Pedruzzi (5753792)

In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin by Stephanie A. Eytcheson (4284421)

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Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…The Fc-RP1 presented anti-amastigote activity against <i>Leishmania amazonensis</i> (IC₅₀ = 0.25 μmol L^–1). In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Three compounds were selected, based on their activity against the intracellular amastigotes (EC₅₀ < 1 μM, SI > 10) and cruzain (IC₅₀ < 100 nM, SI > 5.55) which compared favorably with the approved drug, Benznidazole, and the well-established cruzain inhibitor K777. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Three compounds were selected, based on their activity against the intracellular amastigotes (EC₅₀ < 1 μM, SI > 10) and cruzain (IC₅₀ < 100 nM, SI > 5.55) which compared favorably with the approved drug, Benznidazole, and the well-established cruzain inhibitor K777. …”

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Histology of the perfused intestinal tract at the end of the 3 hours of extracorporeal circulation (H&E stain, 100x, scale bar = 200 μm). by Matteo Dell’Anno (10724418)