Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action by Christopher J. Zerio (11595690)

“…A medicinal chemistry campaign produced the novel eIF4A inhibitor <b>28</b>, which decreased BJAB Burkitt lymphoma cell viability. …”

Cell growth and viability decrease confirmed by growth inhibition in HepG3. by Arlet Hernandez (12289155)

Decreased membrane localization of myrGFP in <i>ACBD6</i>-deficient cells. by Eric Soupene (64584)

Evaluating the Potential of Ozone Microbubbles for Inactivation of Tulane Virus, a Human Norovirus Surrogate by Bozhong Guan (18598178)

“…After 2, 10, and 20 min postgeneration, the ozone concentration of microbubbles naturally decreased from 4 ppm to 3.2 ± 0.2, 2.26 ± 0.19, and 1.49 ± 0.23 ppm and resulted in 1.43 ± 0.44, 0.88 ± 0.5, and 0.68 ± 0.53 log₁₀ viral reductions, respectively, while the ozone concentration of aqueous ozone decreased from 4 ppm to 2.52 ± 0.07, 0.43 ± 0.05, and 0.09 ± 0.01 ppm and produced 0.8 ± 0.28, 0.29 ± 0.41, and 0.16 ± 0.21 log₁₀ reductions against Tulane virus, respectively (<i>p</i> = 0.0526), suggesting that structuring of ozone in the bubbles over the applied treatment conditions did not have a significant effect, though future study with continuous generation of ozone microbubbles is needed.…”

Integrin expression decreased in treated tumors. by Anthony B. Eason (6294305)

Pharmacological inhibition of EGFR decreases early fungal burden and reduces the inflammatory response. by Marc Swidergall (185453)

Protein degradation via the ubiquitin proteasome activity decreases with age and castration tends to increase the activity of this system. by Arik Davidyan (10450896)

Concentration-dependent i⁶A37 modification of cy-tRNA^TrpCCA. by Abdul Khalique (5029442)

Subjects:

Simulation of the average densities/concentrations of the variables for model (2)–(21) with/without ENZ (ADT) at <i>γ</i>_<i>E</i> = 10⁻⁷ g/cm³⋅d.... by Nourridine Siewe (5081834)

nanoDSF apparent melting points. by Aleksi Sutinen (10039145)

Subjects:

The shortened version of the Edinburgh Handedness Inventory encompasses 4 items (e.g. writing) scored on a 5-point scale ranging from:” Always right; usually right; both equally; u... by Marcel F. Hinss (14675457)

Cyclooxygenase inhibition decreases immune control of fungal germination and invasive hyphal growth. by Savini Thrikawala (5690510)

Decreased hyper-resection in a NuA4 acetylation defective mutant in G1 and defect in DNA break repair by SSA. by Salar Ahmad (11457776)

“…(F) The <i>esa1-ts</i> mutation leads to a decrease of DSB repair by resection-based single-strand annealing. …”

Estimates of the phenotypic mean, environmental variance (<i>V</i>_<i>E</i>), additive genetic variance (<i>V</i>_<i>A</i>), and heritability (<i>h</i><sup><i>2... by Ryan M. Imrie (15810854)

A prepubertal CD decreases plasma leptin and cholesterol concentrations in adulthood despite a chronic HFD in Sprague-Dawley male rats. by Ana Aguilar-Lozano (20614619)

Map of spatial GPoE folds and predictive ability by fold. by Forrest Li (21512582)

“…<p>Correlations between genetics and environment are demonstrated through prediction but decrease when considering spatial distance. <b>A)</b> Map of sampled cross-validation folds used in spatial GPoE. …”

The decrease in blood flow disrupts CV pruning. by Lin Wen (557398)

Quantitative decrease of apolipoprotein-A1 by cohort. by Thierry Poynard (38084)

“…<p>Apolipoprotein-A1 decreased (P<0.001) in the three cohorts, starting early in January 2020 (red line with 95% confidence interval) in the US cohort (lower panel).…”

Treatment of astrocytes with morphine decreases expression of neuroinflammatory genes. by Kenneth Chen (8622645)

Higher reward decreases three measures of response variability. by Zvi N. Roth (9611598)