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Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
منشور في 2025"…</p><h3>Materials and methods</h3><p dir="ltr">We used RKO colon cancer cells, blocking HSP90 with the inhibitor AT13387 and HSP90 siRNA. …"
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263
Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990–2021: findings from the Global Burden of Disease Study 2021
منشور في 2024"…The estimated number of stillbirths occurring at 20 weeks' gestation or longer decreased from 5·08 million (95% UI 4·07–6·35) in 1990 to 3·04 million (2·61–3·62) in 2021, corresponding to a 39·8% (31·8–48·0) reduction, which lagged behind a global improvement in neonatal deaths of 45·6% (36·3–53·1) for the same period (down from 4·03 million [3·86–4·22] neonatal deaths in 1990). …"
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Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
منشور في 2024"…Uncertainty from past data inputs and model estimation was propagated throughout analyses by taking 1000 draws for past and present fertility estimates and 500 draws for future forecasts from the estimated distribution for each metric, with 95% uncertainty intervals (UIs) given as the 2·5 and 97·5 percentiles of the draws. To evaluate the forecasting performance of our model and others, we computed skill values—a metric assessing gain in forecasting accuracy—by comparing predicted versus observed ASFRs from the past 15 years (2007–21). …"
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Optimum sizing of steam turbines for concentrated solar power plants
منشور في 2012"…For capacity sizes of 10kWe up to 50MWe, the steam turbine efficiency increases and the steam turbine expected specific capital cost of the power block decreases at a high rate, whereas for larger sizes they remain almost constant. …"
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270
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
منشور في 2020"…<p dir="ltr">A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. …"
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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021
منشور في 2025"…BackgroundDecades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. …"
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272
Genotypic and phenotypic characterization of Candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin
منشور في 2019"…Five isolates were found to contain mutations with the mutations restricted to resistant strains. …"
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273
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
منشور في 2024"…For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). …"
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274
Basophil-VAMP7 is a vital regulator of skin barrier integrity and chronic itch
منشور في 2025"…MethodsBasophil-specific VAMP7 knockout (Ba-V7KO) and control V7fl/fl mice were used to model chronic itch and AIF in AD. …"
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275
Genotypic and phenotypic characterization of candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin. (c2018)
منشور في 2018"…Five isolates were found to contain mutations with the mutations restricted to resistant strains. …"
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masterThesis -
276
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Co-doped zigzag graphene nanoribbon based gas sensor for sensitive detection of H<sub>2</sub>S: DFT study
منشور في 2021"…<p dir="ltr">In this work, we present a highly sensitive gas sensor for the detection of poisonous hydrogen sulfide gas (H<sub>2</sub>S) based on copper and zinc co-doped zigzag graphene nanoribbon (Cu/Zn-ZGNR). …"
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The effect of Dopamine Agonists on patients with advanced Parkinson's disease subjected to subthalamic deep brain stimulation. (c2000)
منشور في 2000"…The following study reports and investigates the efficacy, safety and tolerability of a postoperative therapeutic approach mainly based on dopamine agonists. We run a pilot, prospective, and open-label study on five patients with severe idiopathic PO who underwent STN HFS. …"
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279
Diffusion tensor imaging with tractography in surgical resection of brainstem cavernous malformations: a systematic review and meta-analysis
منشور في 2023"…We used Comprehensive Meta-Analysis (CMA) software to analyze the collected data, get the evidence, and report the results as event rate (ER), with their 95% confidence interval (CI). …"
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