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13841
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13842
Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis
Published 2016“…Pooled analysis revealed significant improvements in FEV<sub>1</sub> (first second forced expiratory volume) (MD = 0.09, 95% CI: 0.06–0.12, <i>I</i><sup><i>2</i></sup> = 10%), FEV<sub>1</sub>% (MD = 3.75, 95% CI: 1.66–5.83, <i>I</i><sup><i>2</i></sup> = 19%), Asthma Quality of Life Questionnaire (AQLQ) score (MD = 0.22, 95% CI: 0.15–0.30, <i>I</i><sup><i>2</i></sup> = 0%), decreased blood, sputum eosinophils and asthmatic exacerbation (RR = 0.66, 95% CI: 0.59–0.73, <i>I</i><sup><i>2</i></sup> = 51%); peak expiratory flow (PEF) (MD = 5.45, 95% CI: -2.83–13.72, <i>I</i><sup><i>2</i></sup> = 0%), histamine PC<sub>20</sub> (MD = -0.62, 95% CI: -1.92–0.68, <i>I</i><sup><i>2</i></sup> = 0%) or SABA rescue use (MD = -0.11, 95% CI: -0.3–0.07, <i>I</i><sup><i>2</i></sup> = 30%) were unaffected; adverse events were not increased (RR = 0.93, 95% CI: 0.89–0.98, <i>I</i><sup><i>2</i></sup> = 46%). …”
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13843
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13844
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13845
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13846
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13847
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13848
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13849
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13850
Treatment adoption and diffusion pattern.
Published 2023“…In clinical studies, voxelotor has been shown to increase hemoglobin (Hb) and decrease hemolytic markers in patients with SCD. The objective of this study was to estimate the impact of voxelotor on the burden of SCD in France using a modeling approach, accounting for its anticipated adoption and diffusion over the next 5 years. …”
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13851
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13852
Image3_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF
Published 2024“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”
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13853
Image1_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF
Published 2024“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”
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13854
Table1_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.DOCX
Published 2024“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”
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13855
Image2_Circ-CDK8 regulates SLC7A11-mediated ferroptosis by inhibiting miR-615-5p to promote progression in oral squamous cell carcinomas.TIF
Published 2024“…Bioinformatics analyses and luciferase reporter assays were performed and revealed targeted relationships between circ-CDK8 and miR-615-5p, miR-615-5p and SLC7A11. Interference with circ-CDK8 expression reduced SLC7A11 expression by sponging miR-615-5p, suppressed OSCC cell migration and invasion, and promoted ferroptosis by increasing ROS, MDA, and iron levels and decreasing GSH and GPX4 levels in OSCC cells. …”
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13856
Combustion Characteristics of C<sub>5</sub> Alcohols and a Skeletal Mechanism for Homogeneous Charge Compression Ignition Combustion Simulation
Published 2015“…C<sub>5</sub> alcohol blending in PRF75 in HCCI combustion leads to a significant decrease of low-temperature heat release (LTHR) and a delay of the main combustion. …”
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13857
Combustion Characteristics of C<sub>5</sub> Alcohols and a Skeletal Mechanism for Homogeneous Charge Compression Ignition Combustion Simulation
Published 2015“…C<sub>5</sub> alcohol blending in PRF75 in HCCI combustion leads to a significant decrease of low-temperature heat release (LTHR) and a delay of the main combustion. …”
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13858
Combustion Characteristics of C<sub>5</sub> Alcohols and a Skeletal Mechanism for Homogeneous Charge Compression Ignition Combustion Simulation
Published 2015“…C<sub>5</sub> alcohol blending in PRF75 in HCCI combustion leads to a significant decrease of low-temperature heat release (LTHR) and a delay of the main combustion. …”
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13859
COVID19 effect on essential services.
Published 2024“…The present study found that the mean number of patients treated for TB declined by 35 patients (β: -34.62; 95%CI: -50.29, -18.95) compared to the pre-COVID-19 era while the number of new patients enrolled for ART decreased by 71 patients (β: -70.62; 95%CI: -107.19, -34.05). …”
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13860