Showing 681 - 700 results of 21,480 for search '(( 5 step decrease ) OR ( 100 ((((nm decrease) OR (nn decrease))) OR (a decrease)) ))', query time: 0.84s Refine Results
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    Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity by Elizabeth S. Childress (2116453)

    Published 2017
    “…Surprisingly, combining features of reported SphK1 inhibitors generated SphK1/2 dual inhibitor <b>20l</b> (SLC4011540) (hSphK1 <i>K</i><sub>i</sub> = 120 nM, hSphK2 <i>K</i><sub>i</sub> = 90 nM) and SphK2 inhibitor <b>20dd</b> (SLC4101431) (<i>K</i><sub>i</sub> = 90 nM, 100-fold SphK2 selectivity). …”
  14. 694

    Propofol increased the number of the hippocampal pyramidal neurons and decreased the expression of the LC3-II protein and the number of lysosomes and autophagosomes in the ischemic... by Derong Cui (326839)

    Published 2013
    “…<p>I/R was induced by 2-vessel occlusion. Propofol 10, 50, or 100 mg/kg was administrated intraperitoneally and 3-MA (600 nM) was administered intracerebroventricularly 10 min after the onset of ischemia. (1) Sham-operated group (control group, Cont); (2) I/R group; (3) I/R+ 3-MA 600 nmol group; (4) I/R + propofol 10 mg/kg group; (5) I/R + propofol 50 mg/kg group; (6) I/R + propofol 100 mg/kg group; (7) I/R + vehicle (intralipid, 100 mg/kg) group. …”
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    Repetitive stress induces a decrease in sound-evoked activity. by Ghattas Bisharat (20706928)

    Published 2025
    “…Marked at time = 0 is the onset of the 100-ms white noise. (f) A second group of mice followed the same procedures but without experiencing daily restraint stress (<i>N</i> = 3 mice, <i>n</i> = 123 neurons). …”
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