Data_Sheet_3_Integrating Ligand and Target-Driven Based Virtual Screening Approaches With in vitro Human Cell Line Models and Time-Resolved Fluorescence Resonance Energy Transfer A... by Gurbet Tutumlu (8691720)

“…In the first approach, a molecular docking and filtering approach is used to rank compounds based on their docking scores and only a few top-ranked molecules are selected for further long (100-ns) molecular dynamics (MD) simulations and in vitro tests. …”

Data_Sheet_2_Integrating Ligand and Target-Driven Based Virtual Screening Approaches With in vitro Human Cell Line Models and Time-Resolved Fluorescence Resonance Energy Transfer A... by Gurbet Tutumlu (8691720)

“…In the first approach, a molecular docking and filtering approach is used to rank compounds based on their docking scores and only a few top-ranked molecules are selected for further long (100-ns) molecular dynamics (MD) simulations and in vitro tests. …”

Figure 3 by Michael S. Akhras (60473)

“…<b>C</b>) DNA amounts were set at 100 ng for HPV-45 plasmid and 1 nanogram for HPV-59 plasmid, which was observed as a ∼3-fold decrease in signal intensity. …”

Data_Sheet_1_Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic In... by Matthew R. Barron (8533815)

“…<p>Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). …”

Supplementary Material for: Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Children and Youth Aged 0-19 Years: Data from the Global and Regional Burden of Strok... by Krishnamurthi R.V. (3236010)

“…While prevalence rates for childhood IS and HS decreased significantly in developed countries, a decline was seen only in HS, with no change in prevalence rates of IS, in developing countries. …”

Hierarchically clustered ANIm heatmap across Set-R combined with phylogenetic information reveals unknown species diversity within the ACB clade. by Bardya Djahanschiri (6203681)

“…These clusters and cutoffs are typically used for bacterial species delineation. In the ACB clade, we observe a large and distinct cluster with 98–100% sequence identity (rounded) for the <i>A</i>. …”

Topographic outcomes after corneal collagen crosslinking in progressive keratoconus: 1-year follow-up by Mauro C. Tiveron Jr (5760554)

“…Methods: We performed a retrospective, analytical, and observational study of 100 eyes from 74 progressive KC patients who underwent CXL at the Eye Hospital of Paraná. …”

Deterministic sensitivity analysis. by Katharina Wahedi (7136459)

“…Bars on the right indicate an increase of ICER, bars on the left show a decrease of ICER. Changes resulting from increasing the parameters are represented by green bars while those resulting from a decrease of parameters are shown in red.…”

Light Stimulation Protocols. by Katherine E. Davis (534184)

“…The magnitude of this melanopsin step could be varied by mixing blue and yellow in the step (increasing the yellow and decreasing the blue elicited decreasing levels of contrast). …”

Characterisation of stimulating rat anti-β1EC2. by Valérie Boivin (694135)

“…<p>(A) ELISA-reactivity (mean±SEM) of n = 6 representative rat anti- β₁EC2 (1:5000, 12h, 4°C) with linear (dark green) or cyclic β₁EC2-peptides (light green); <i>p</i><0.005 (Student’s t-test). …”

Resveratrol Protects Chondrocytes from Apoptosis via Altering the Ultrastructural and Biomechanical Properties: An AFM Study by Hua Jin (320594)

“…CCK-8 assay showed that 100 μM RV significantly prevented SNP-induced cytotoxicity. …”

Characterization of LNCaP cell growth cultured within biomimetic hydrogels in normal growth media, RPMI and 10% FBS. by Shirly Sieh (139080)

“…<p>(A) Growth curves of LNCaP cells over 7 days for 2D cultures (left) and 28 days for 3D cultures (right) in normal growth media measured by total DNA content (mean ± SE). …”

Selectivity of PRMT5 inhibition with C220. by Shelby L. Sloan (10803222)

“…For all cell lines, effects of PRMT5 inhibition with C220 treatment on biomarkers of PRMT5 activity shows a dose-dependent decrease in global marks of symmetric di-methylarginine (SDMA) and symmetric di-methylation of histone H4 arginine-3 (H4R3me2s) with a minimal effect to PRMT5 or global asymmetric di-methylarginine (ADMA). …”

HIV-1 envelope glycoprotein gp41 schematic and structure of the 2F5 antibody-peptide complex. by Javier Guenaga (150719)

“…Residues at the apex of the CDRH3 in magenta (_100ALFGV_100D) were not altered. …”

Table_1_Study on the additional financial burden of breast cancer disease on cancer patients and their families. Financial toxicity in cancer.XLSX by Eduardo J. Fernandez-Rodriguez (18963088)

“…However, after being diagnosed with breast cancer, there is a significant income decrease of 15.91%, resulting in a reduced average annual income of 16785.98 euros. …”

Reduction of plasma membrane PtdIns(4)<i>P</i> and PtdIns(4,5)<i>P</i>₂ levels and their effect on the Ins<i>P</i>₃ and Ca²⁺ signals upon hormonal... by Gergő Gulyás (733813)

“…(E and F) HEK 293T cells were transiently transfected with AT1R-Δ319 together with the indicated BRET sensors. A 10-minute preincubation with 10 μM wortmannin or 10 nM A1 was used to decrease the PtdIns(4)<i>P</i> level of the PM. …”

Possible Increase in Serum FABP4 Level Despite Adiposity Reduction by Canagliflozin, an SGLT2 Inhibitor by Masato Furuhashi (85555)

“…Treatment with canagliflozin significantly decreased adiposity and levels of fasting glucose and HbA1c but increased average serum FABP4 level by 10.3% (18.0 ± 1.0 vs. 19.8 ± 1.2 ng/ml, P = 0.008), though elevation of FABP4 level after treatment was observed in 26 (66.7%) out of 39 patients. …”

<i>ACVR2</i> promoter hypermethylation and LOH in colon cancer specimens and the MSS HT29 cell line and correlation of <i>ACVR2</i> promoter hypermethylation and loss of <i>ACVR2</... by Barbara Jung (155690)

“…<p>A) ACVR2 promoter with map of positioning of MSP primers B) Using a CpG islands search program, we identified the CpG islands within the <i>ACVR2</i> promoter based upon following stringent criteria: ∼CG percentage>55%; observed CpG/expected CpG >0.65; length >500 bp. …”

Supplementary Material for: The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in... by Reuther C. (3593810)

“…The small molecule NVP-CGM097 is a novel MDM2 inhibitor. We investigated MDM2 inhibition as a target in neuroendocrine tumor cells in vitro. …”

Data_Sheet_1_Transcriptome and Proteomics Analysis of Wheat Seedling Roots Reveals That Increasing NH4+/NO3– Ratio Induced Root Lignification and Reduced Nitrogen Utilization.DOCX... by Dongqing Yang (675454)

“…However, the mechanisms underlying the response of wheat seedling roots to changes in NH₄⁺/NO₃^– ratio remain unclear. In this study, we investigated wheat growth, transcriptome, and proteome profiles of roots in response to increasing NH₄⁺/NO₃^– ratios (N_a: 100/0; N_r1: 75/25, N_r2: 50/50, N_r3: 25/75, and N_n: 0/100). …”