Supplementary Material for: Protease-activated receptor 2 controls vascular smooth muscle cell proliferation in cyclic AMP-dependent protein kinase/mitogen-activated protein kinase... by Williams M.D. (17000277)

“…Introduction: Cardiovascular disorders are characterized by vascular smooth muscle (VSM) transition from a contractile to proliferative state. Protease-activated receptor 2 (PAR2) involvement in this phenotypic conversion remains unclear. …”

Data Sheet 1_Carbon finance for forest resilience in California.docx by Micah Elias (20601650)

“…<p>Restoring a resilient forest structure in California’s American River watershed in the Sierra Nevada mountains can generate up to $6,100 per acre in carbon revenue from increased forest carbon and market-ready biomass utilization pathways, potentially fully funding forest management. …”

Molecular mechanisms underlying Tao-Hong-Si-Wu decoction treating hyperpigmentation based on network pharmacology, Mendelian randomization analysis, and experimental verification by Jun Chen (4238)

“…<p>Hyperpigmentation, a common skin condition marked by excessive melanin production, currently has limited effective treatment options.…”

Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans by Zuyi Weng (109988)

“…Unfortunately, disodium cromoglycate (cromolyn), the only compound marketed as a mast cell “stabilizer”, is not particularly effective in blocking human mast cells. …”

DataSheet1_PBPK Modelling of Dexamethasone in Patients With COVID-19 and Liver Disease.DOCX by Maiara Camotti Montanha (12013826)

“…<p>The aim of the study was to apply Physiologically-Based Pharmacokinetic (PBPK) modelling to predict the effect of liver disease (LD) on the pharmacokinetics (PK) of dexamethasone (DEX) in the treatment of COVID-19. A whole-body PBPK model was created to simulate 100 adult individuals aged 18–60 years. …”

Image_2_Combining Organic Fertilizer With Controlled-Release Urea to Reduce Nitrogen Leaching and Promote Wheat Yields.JPEG by Xiuyi Yang (9648902)

“…NO3−-N and NH4+-N were mainly concentrated in the 0–60-cm layer soil by OF substitution, and N leaching to the 60–100-cm soil layer was significantly reduced. Hence, the results suggest that the combination of 30–50% OF with CU synchronizes absorption with availability due to a period of increased N availability in soils and proved to be the best strategy for simultaneously increasing wheat production and reducing N leaching.…”

Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone by Stephen R. Morairty (153484)

“…The increased NR was due to a greater number of NR bouts; NR bout duration was unchanged. …”

Data_Sheet_1_In vitro Activity of Antivirulence Drugs Targeting the las or pqs Quorum Sensing Against Cystic Fibrosis Pseudomonas aeruginosa Isolates.PDF by Diletta Collalto (12453003)

“…Niclosamide showed an overall low range of activity and its negative effect on las signal production did not correlate with a decreased production of virulence factors. On the other hand, clofoctol displayed a broader QS inhibitory effect in CF isolates, with consequent reduction of the pqs-controlled virulence factor pyocyanin. …”

Image_1_High-dimensional single-cell analysis unveils distinct immune signatures of peripheral blood in patients with pancreatic ductal adenocarcinoma.pdf by Yu Pan (162493)

“…The proportion of cytotoxic CD8+ T cells and the level of cytotoxicity per cell were increased in PDAC patients, with reduced TCR clonal diversity. We also found a significantly enriched S100A9+ monocyte population and an increased level of TIM-3 expression in immune cells of peripheral blood in PDAC patients. …”

DNA Repair and Cell Cycle Biomarkers of Radiation Exposure and Inflammation Stress in Human Blood by Helen Budworth (121329)

“…Radiation exposure significantly modulated the transcript expression of 12 genes of 40 tested (2.2E-06CDKN1A, FDXR, BBC3, PCNA, GADD45a, XPC, POLH and <em>DDB2</em>). …”

Altered regulation of Prox1-gene-expression in liver tumors-5 by Jozsef Dudas (46097)

“…When the nuclear extracts were reacted with the same radiolabelled consensus double-stranded oligo in the presence of a 100-fold excess of an unlabeled MAZ-consensus oligo (published in ref. [23]) the intensity of mobility shift significantly decreased (right panel); sample 1: negative control, without nuclear extract. …”

DataSheet1_Effects of Poplar Ecological Retreat on Habitat Suitability for Migratory Birds in China’s Dongting Lake Wetland.PDF by Xinyu Qu (8107580)

“…The suitability included four grades: poorly (0–25), generally (25–50), moderately (50–75), and highly (75–100). The results showed that the area of poplars in Dongting Lake wetland decreased significantly after PER was implemented. …”

Table_3_ZnO nanoparticles efficiently enhance drought tolerance in Dracocephalum kotschyi through altering physiological, biochemical and elemental contents.docx by Zahra Karimian (9677772)

“…We aimed to determine the impacts of zinc nanoparticles (ZnO-N) and zinc sulfate (ZnSO₄) fertilizers on the improvement of drought tolerance in Dracocephalum kotschyi as a medicinal-ornamental plant. Plants were treated with three doses of ZnO-N and ZnSO₄ (0, 10, and 20 mg/l) under two levels of drought stress [50% and 100% field capacity (FC)]. …”

Table 3_Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.docx by Yinghong Zhou (6873053)

“…Interventional trials first posted between 2015 and 2024 were included if they used drugs as interventions and had treatment as the primary purpose.</p>Results<p>A total of 2,928 pediatric-only clinical trials were included, with annual registration numbers ranging from 257 to 339, exhibiting a declining trend. …”

DataSheet1_Chrysanthemum indicum L. ameliorates muscle atrophy by improving glucose tolerance in CT26-induced cancer cachexia.docx by Gahee Song (8933261)

“…After 1 week, the mice were orally administered vehicle, CI (100 mg/kg), or Celecoxib (50 mg/kg) for 3 weeks.…”

Table 2_Characteristics of pediatric interventional drug trials registered between 2015 and 2024 on ClinicalTrials.gov.docx by Yinghong Zhou (6873053)

“…Interventional trials first posted between 2015 and 2024 were included if they used drugs as interventions and had treatment as the primary purpose.</p>Results<p>A total of 2,928 pediatric-only clinical trials were included, with annual registration numbers ranging from 257 to 339, exhibiting a declining trend. …”

DataSheet_1_Anti-inflammatory, antioxidant and anti-virulence roles of atractylodin in attenuating Listeria monocytogenes infection.doc by Lei Xu (78676)

“…Congruently, the survival rate of L. monocytogenes-infection mice increased significantly from 10.0% to 40.0% by atractylodin treatment.</p>Conclusion<p>Collectively, our study showed for the first time that atractylodin has tremendous potential to attenuate L. monocytogenes pathogenicity by blocking LLO pore formation and mediating the suppression of inflammation and oxidative stress, providing a promising therapeutic strategy and broadening the applications of atractylodin against L. monocytogenes infection.…”

Image_1_Combining Organic Fertilizer With Controlled-Release Urea to Reduce Nitrogen Leaching and Promote Wheat Yields.JPEG by Xiuyi Yang (9648902)

“…NO3−-N and NH4+-N were mainly concentrated in the 0–60-cm layer soil by OF substitution, and N leaching to the 60–100-cm soil layer was significantly reduced. Hence, the results suggest that the combination of 30–50% OF with CU synchronizes absorption with availability due to a period of increased N availability in soils and proved to be the best strategy for simultaneously increasing wheat production and reducing N leaching.…”

Metformin Changes the Relationship between Blood Monocyte Toll-Like Receptor 4 Levels and Nonalcoholic Fatty Liver Disease—<i>Ex Vivo</i> Studies by Agnieszka Zwolak (760122)

“…In ex vivo studies, 100 μM of metformin decreased the TLR4 level by 19.9% (II group) or by 35% (III group) as well as IL-1β and TNFα production. …”

Improvement of Methane Hydrate Formation Using Biofriendly Amino Acids for Natural Gas Storage Applications: Kinetic and Morphology Insights by Chuvich Chaovarin (13925079)

“…The experiments were conducted at 8 MPa and 277.2 K using a hybrid combinatorial reactor approach at various amino acid concentrations (0.10 to 1.00). …”