Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T... by Jiaxing Zhao (3965057)

“…Specifically, compound <b>20g</b> displayed a 3.67-fold decrease of plasma AUC_{(tofacitinib, 0–∞)} and a 9.61-fold increase of colonic AUC_{(tofacitinib, 0–12h)}, compared with tofacitinib at a molar equivalent oral dose. …”

Fig 5 - by Frank Rattay (127304)

Subjects:

Fig 5 - by Ina Jahreis (11752073)

VOC Alpha spike protein shows decreased proteolytic processing. by Daniela Niemeyer (199082)

Variants enriched in an <i>Ae</i>. <i>aegypti</i> cell line <i>(</i>Aag2) have increased fitness in Aag2 cells but decreased fitness in a human cell line (MRC-5). by Chelsea Cereghino (15188341)

TBEV infection decrease levels of 18S and 28S rRNA but not 5S rRNA. by Martin Selinger (3195987)

MiR-129-5p levels were decreased in mouse depression models. by Qiaozhen Qin (13159201)

“…<p><b>A.</b> Experimental schedule. All mice underwent behavioral tests following CRS treatment. …”

MeV disrupted mitochondrial network and cellular metabolism. by Pierre Khalfi (7868252)

Subjects:

Raw data 1–5. by Fateme Khorramroo (18086501)

Muscle-specific knockdown of <i>nSMase</i> decreases a subset of ceramide species that are decreased in <i>Gba1b</i> mutants. by Kathryn A. Jewett (3756811)

The saturated fatty acid palmitate decreases viability and induces apoptosis in HUVECs. by Dustin M. Lee (8207457)

HA-MAD1 tumors have increased CIN and decreased p53. by Sarah E. Copeland (13951506)

5-fold cross-validation comparison results. by Chunming Wen (17616274)

Algorithm operation steps. by Junyan Wang (4738518)

“…Experimental results demonstrate that SCI-YOLO11 achieves a 3.2% improvement over baseline models in terms of MAP@0.5 metric; precision and recall rates increase by 2.6% and 3.7%, respectively. …”

Flow chart of the expression-based functional screen, with validation steps. by Mohamad Karaky (8910497)

Subjects:

HVR1-swap compensatory E1/E2 substitutions typically decrease virus entry dependency on SR-BI. by Christina Holmboe Olesen (11154333)

Fig 5 - by Rabeya Binta Alam (17364707)

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)

S1 Fig - by Asadollahi Parisa (8837432)

Subjects:

Macroscopic and histological assessment of colic tumor and inflammation in mice. by Asadollahi Parisa (8837432)

Subjects: