Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy by Aditya Bhattacharya (4499686)

“…Treatment of 3T3L1 cells with LTK-14A abolished adipogenesis with downregulation of pro-adipogenic genes along with inhibition of H4K5 butyrylation. …”

Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy by Aditya Bhattacharya (4499686)

“…Treatment of 3T3L1 cells with LTK-14A abolished adipogenesis with downregulation of pro-adipogenic genes along with inhibition of H4K5 butyrylation. …”

DataSheet1_Advanced in Vitro Safety Assessment of Herbal Medicines for the Treatment of Non-Psychotic Mental Disorders in Pregnancy.pdf by Deborah Spiess (10699319)

“…John’s wort) and valtrate (typical for valerian) were the most obvious phytochemicals with respect to cytotoxic and apoptotic effects. A decrease in cell viability was evident with hypericin (≥1 µM) and valtrate (≥10 µM), whereas hyperforin (≥3 µM), hypericin (30 µM) and valtrate (≥10 µM) induced cell apoptosis. …”

DataSheet_2_Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion.pdf by Gabriel A. Aguirre (4354087)

“…We also observed that circulating concentrations of RvD5_{n-3 DPA} levels were decreased in peripheral blood of metastatic PDAC patients when compared with those measured in plasma of non-metastatic PDAC patients. …”

DataSheet_1_Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion.doc by Gabriel A. Aguirre (4354087)

“…We also observed that circulating concentrations of RvD5_{n-3 DPA} levels were decreased in peripheral blood of metastatic PDAC patients when compared with those measured in plasma of non-metastatic PDAC patients. …”

DataSheet_1_Arachidonate 15-lipoxygenase-mediated production of Resolvin D5n-3 DPA abrogates pancreatic stellate cell-induced cancer cell invasion.pdf by Gabriel A. Aguirre (4354087)

“…We also observed that circulating concentrations of RvD5_{n-3 DPA} levels were decreased in peripheral blood of metastatic PDAC patients when compared with those measured in plasma of non-metastatic PDAC patients. …”

Effect of rec.5S rRNA expression on the heteroplasmy level of KSS mutation. by Romuald Loutre (5410142)

“…<p>(<b>a</b>) Proportion of KSS mtDNA (Y axis) in cybrids cell lines with low expression of rec.5S rRNA versions (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0199258#pone.0199258.t001" target="_blank">Table 1</a>) after 8 weeks of cultivation in high glucose or glucose-free media, as indicated. …”

Inhibitors of 5-LOX block TRPM7-mediated cell rounding. by Hsiang-Chin Chen (247146)

“…<p>(A) Application of the 5-LOX inhibitors NDGA (10 µM), AA861 (10 µM), and MK886 (10 µM) to 293-TRPM7 expressing cells reduced cell rounding. …”

Serum uric acid levels in patients with Parkinson’s disease: A meta-analysis by Min Wen (3549752)

“…Analyses were performed by using Review Manager 5.3 and Stata 11.0.</p><p>Results</p><p>Thirteen studies with a total of 4646 participants (2379 PD patients and 2267 controls) were included in this meta-analysis. …”

Inhibition of Cdk5 Activity Attenuates Dendritic Spine Formation and Maturation by Sebastian Jessberger (269496)

“…</p> <p>(B) Inhibition of cdk5 activity did not affect the formation but decreased the maturation of dendritic spines on apical dendrites of <i>DNcdk5</i>-expressing granule cells, whereas <i>DNcdk5</i>-expressing neurons with aberrantly targeted basal dendrites (BasalDNcdk5) showed a decrease in both formation and maturation of dendritic spines. …”

Related to Fig 3. by Mohammad Nafees Ansari (22232505)

“…(<b>Q</b>) Tumor growth kinetics recorded a significantly higher growth of BT-474_ZFX^OE (mean ± SEM, <i>n</i> = 5) than BT-474_VECT^OE tumors. …”

Image_4_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_8_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_6_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_9_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_1_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_3_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_10_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_7_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”

Image_2_Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner.TIF by Charles B. Trelford (11601802)

“…We demonstrated that TGFβ1 increases Unc 51-like kinase 1 (ULK1) protein levels, 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent ULK1 phosphorylation at serine (S) 555 and ULK1 complex formation but decreases mechanistic target of rapamycin (mTOR) activity on ULK1. …”