EYA inhibitor Benzbromarone, compound 1. by Emmanuel Tadjuidje (325188)

“…(<b>c</b>) Plots of Vmax and Km as a function of inhibitor concentration show that both values decrease with increased inhibitor concentration. …”

Colocalization of the lipid and MinD spirals by Imrich Barák (48941)

“…Images B and E show the FM 4-64 (acceptor) fluorescence signal before and after photobleaching. A decrease in intensity can clearly be seen within the marked region. …”

Aerofoil Design for Unmanned High-Altitude Aft-Swept Flying Wings by Ahmad Abdulkarim Alsahlan (4659976)

“…The second part contains the optimisation code using a genetic algorithm. The primary target here was to design a number of aerofoils with low pitching moment, suitable for an aft-swept flying wing configuration operating at low Reynolds number in the range of about 0.5 × 106. …”

The NH₂-terminus of PDX-1 binds to <i>Krt19</i> promoter DNA. by Johannes von Burstin (243524)

“…C) MIN6 cells were transfected with V5-tagged full length PDX-1 or PDX-1 Δ1-37. DNA precipitation was carried out as described above, and membranes were probed with anti-V5. …”

Determinants of Sensitivity to DZNep Induced Apoptosis in Multiple Myeloma Cells by Zhigang Xie (203103)

“…Western-blot analysis indicated ALOX5 was highly expressed only in sensitive cell line H929 and greatly decreased upon DZNep treatment. …”

Protist-Type Lysozymes of the Nematode <em>Caenorhabditis elegans</em> Contribute to Resistance against Pathogenic <em>Bacillus thuringiensis</em> by Claudia Boehnisch (74713)

“…A functional genetic analysis was performed for three of these genes, each belonging to a distinct evolutionary lineage within the protist-type lysozymes (<em>lys-2</em>, <em>lys-5</em>, and <em>lys-7</em>). …”

Metabolomics raw data and table of extracted peak areas for BT478, BT530 and NHA cells cultured in the presence of MPA, Compound 3 (IC80) or vehicle control, for 6 hours. by Agata Monika Kieliszek (14650298)

“…The linear gradient employed was as follows: 0–2.5 min 99% A, 2.5–7.5 min decrease to 80% A, 7.5–13 min to 55% B 652 and finally 13–15 min to 99% B and held for 1 min. …”

Macrophage-tropic HIV-1 isolates, which are known to bind human CD4 more tightly, are promiscuous in their use of primate CD4 receptors. by Cody J. Warren (563898)

“…<p>(A, B) Cells stably expressing various primate CD4 receptors (x-axis), along with human CCR5, were infected with Q23ΔEnv-GFP pseudotyped with (A) early HIV-1 Envelopes (Envs) or (B) Envs from common macrophage-tropic HIV-1 isolates. …”

Aquaporin and red cell O2 permeability by S. Al-Samir (20965502)

“…In addition, the AQP1 inhibitor 5-(phenoxymethyl)furan-2-carbaldehyde) (5-PMFC) decreases human red cell PO2 by ~40%. …”

The STIM2-TM domain activates the cytosolic region of STIMs less efficiently than that of STIM1. by Sisi Zheng (1574473)

“…Left: average time course of whole-cell I_CRAC currents measured at –100 mV. Currents mediated by STIM1121-ΔK developed significantly more slowly than control (time to peak, 72 ± 7 s versus 147 ± 9 s, <i>n</i> = 7, ****<i>P</i> < 0.0001, <i>t</i> test), with the maximal current density also reduced (–5.5 ± 0.8 pA/pF versus –1.5 ± 0.1 pA/pF, <i>n</i> = 7, *****<i>P</i> < 0.0004, <i>t</i> test). …”

Principle of time-resolved Scintillation Proximity Assay (SPA) to quantify stability of high-affinity radio-ligand binding to GPCRs. by Randi Westh Hansen (2585833)

“…When radioligands bind to immobilized receptors, energy from the radioisotope decay is efficiently transferred to the scintillator contained in the beads, thus generating a detectable light signal. If the buffer, including detergent, causes the loss of receptor affinity to radiolabeled ligand, the signal will start to decrease irreversibly. …”

Endothelial density analysis by age group of corneal donors in an eye bank in Paraná State, Brazil by Karla Mulinari Vicini (10371090)

“…In the evaluation from the second to the sixth decade, there was no pattern, sometimes there was an increase, sometimes a decrease in the average endothelial density.</p><p></p>…”

Rad51 stimulates expression of integrated copies of HIV-1. by Rafal Kaminski (179554)

“…<p><b>(A)</b> TZM-bl cells multiple endogenous integrated copies of LTR-luciferase were transfected with 0, 3, 10 and 30 ng of pCMV (lanes 1–4 or 5–8, respectively). …”

Reduced but functional CD8+ T-cell compartment after fully-mismatched HLA class I thymus transplantation. by Adriana S. Albuquerque (323475)

“…<p>(A) Circulating CD8+ αβ T-cells analysed 58 months post-transplantation (5% of total lymphocytes; 83cells/µl) by flow cytometry in terms of: naïve/memory/effector phenotype assessed by CD45RA and CD27 expression; levels of activation markers (CD38 and HLA-DR); IFN-γ and IL-2 production upon PMA+ionomycin stimulation; <i>ex vivo</i> frequency of cycling cells (Ki-67+); and <i>ex vivo</i> frequency of apoptotic cells assessed by annexin V staining. …”

Nephrin deletion in adult mature glomerulus results in focal segmental glomerulosclerosis and proteinuria. by Rakesh Verma (151646)

“…<p>(A) Mice with tamoxifen-induced nephrin deletion develop proteinuria at 6–8 weeks following tamoxifen. …”

LCN2 reduced the increase of endothelial permeability in response to TNFα. by Yang Du (506908)

“…(C) TNFα treatment significantly decreased the total protein expression of VE-cadherin, claudin-5, occludin, and ZO-1. *, p<0.05 compared to the control (one-way ANOVA). n = 3 independent experiments. …”

Oligomerization of hIKK2 dimers. by Smarajit Polley (420092)

“…(E) In vitro kinase assay reveals that catalytic activity of hIKK2 with mutations that disrupt the V-shaped interface (lanes 3–5) is drastically reduced compared to wild-type protein (WT-lane 2). …”

Supplementary Material for: Sensitivity of Blood Volume Monitoring for Fluid Status Assessment in Hemodialysis Patients by Maduell F. (4137250)

Comparison of methods to monitor for myelopathic progression in DCM. by Allan R. Martin (3772705)

“…<p>Top panel: The bar graph displays the fraction of subjects that are deemed to be stable (green), borderline declined (yellow), or declined (red) for each clinical and MRI method of monitoring. For mJOA, a 1-point decrease is considered borderline and ≥ 2-point decreases are considered declined. …”

Specificity and sensitivity of C4BP and FH binding by <i>P. intermedia</i> ATCC 25611. by Sven Malm (326396)

“…<p>A) Binding of 250 kcpm ¹²⁵I-C4BP was competed by using 30 µg (final concentration 1.32 µM) unlabeled C4BP, C) ¹²⁵I-FH binding by <i>P. intermedia</i> ATCC 25611 was competed by 7.5 µg (final concentration 1.25 µM) unlabeled FH. …”