NS affects the PI3K/AKT/mTOR pathway in RAW264.7 cells. by Yihua Wang (491766)

NS enhances autophagy inhibits atherosclerosis in RAW264.7 cells. by Yihua Wang (491766)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

NS delays the formation of atherosclerotic plaques in ApoE^-/- mouse models. by Yihua Wang (491766)

NS attenuates ox-LDL-induced foam cell formation. by Yihua Wang (491766)

NS affects lipid transport in ApoE^-/-mouse models. by Yihua Wang (491766)

MST1was downregulated in macrophages from fibrotic livers of <i>S</i>. <i>japonicum</i>-infected mice and SEA-treated RAW264.7 cells. by Jianyang Li (461703)

Secondary attack rates among 1407 close contacts based on case-patient^a characteristics, their own characteristics, and exposure setting. by Joseph Walker (4341838)

Thin and thick slice perfusion maps. by Edwin Bennink (568194)

Redesigning BinQ catalytic specificity for the human CCR5 gene and AAVS1 safe harbor locus. by Mark C. Wallen (800888)

“…(<b>B, C)</b> Selection of BinQ mutants that recombine the symmetrical versions of the “left” (blue) and “right” (red) <b>(B)</b> AAVS1 and <b>(C)</b> CCR5 target sites. Asterisks indicate selection steps in which incubation time was decreased from 16 to 4 hr. …”

Effects (mean ln R and 95% CI) of live, dead, artificial crab spiders (model), past predation events (PPE) and objects that do no resemble predators on pollinator visitation rate o... by Gustavo Q. Romero (217663)

Average Φ and surprisal over trial time for the easy task (black), the hard task (blue) and perfect animats in the hard task (red). by Christoffer Lundbak Olesen (17262937)

Predicting Dinitrogen Activation and Coupling with Carbon Dioxide and Other Small Molecules by Methyleneborane: A Combined DFT and Machine Learning Study by Feiying You (22119041)

Mendelian randomization results with COVID-19. by Alish B. Palmos (5857379)

Expression of CRYAB in normal and tumor tissue samples across different cancer types. by Rasool Saghaleyni (10526301)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Flowchart style diagram of methods to sex GD 16.5 to GD 18.0 mice using the external genitalia. by Laura B. Murdaugh (5059100)

“…<p>Steps are listed in decreasing order of effectiveness for mice at GD 17.0–17.5; Step 1 is the most effective, and step 4 is the least effective. …”