Rac1 Deletion Causes Thymic Atrophy by Lukas Hunziker (36153)

“…Here we demonstrate that deletion of Rac1 in Keratin 5/Keratin 14 expressing embryonic and adult thymic epithelial cells leads to loss of the thymic epithelial compartment. …”

Comparison of normalization methods. by Mikhail G. Dozmorov (242442)

“…Four different normalizations were applied to the resulting data: Two-step normalization, Quantile, Lowess, and VSN. Associative analysis (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012657#s2" target="_blank">Materials and Methods</a>) was used for the selection of differentially expressed genes with Fd/Fa/Em = 2/1.5/20 restrictions in all these cases. …”

Highly Conductive and Mechanically Robust Cellulose Nanocomposite Hydrogels with Antifreezing and Antidehydration Performances for Flexible Humidity Sensors by Jie Yu (150626)

“…However, the conventional water-based conductive hydrogels tend to inevitably freeze at subzero temperature and suffer from continuous water evaporation under ambient conditions, leading to a decrease in their electrical conductivities and mechanical properties. …”

Data_Sheet_1_Influence of Community-Led Total Sanitation and Water Coverages in the Control of Cholera in Madarounfa, Niger (2018).docx by Julien Graveleau (10717281)

“…<p>Every year, cholera affects 1.3–4.0 million people worldwide with a particularly high presence in Africa. Based on recent studies, effective targeting interventions in hotspots could eliminate up to 50% of cases in Sub-Saharan Africa. …”

Data_Sheet_1_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…The models were also applied to estimate all-cause excess deaths “not directly attributable to COVD-19”, i.e., without a previous COVID-19 diagnosis. During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Data_Sheet_2_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…The models were also applied to estimate all-cause excess deaths “not directly attributable to COVD-19”, i.e., without a previous COVID-19 diagnosis. During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Data_Sheet_1_Inhibiting methanogenesis by targeting thermodynamics and enzymatic reactions in mixed cultures of rumen microbes in vitro.PDF by Kairi Tanaka (19418200)

“…Here, we provide a proof of concept that the combination of an electron acceptor and a methane analog may be exploited to improve microbial efficiency via methanogenesis inhibition.…”

Recent incidence and surgery trends for prostate cancer: Towards an attenuation of overdiagnosis and overtreatment? by Sabrina Jegerlehner (4110049)

“…Since 1998, the annual age-standardised mortality rate of prostate cancer slightly declined in men aged 50–69 years (absolute mean annual change -0.1/100,000, 95% CI: -0.2 to -0.1) and ≥ 70 years (absolute mean annual change -0.5/100,000, 95% CI: -0.7 to -0.3).…”

Data_Sheet_1_The combined impact of redcedar encroachment and climate change on water resources in the Nebraska Sand Hills.docx by Yaser Kishawi (12959564)

“…Four plausible redcedar encroachment scenarios, namely 0.5% (no encroachment), 2.4, 4.6, and 11.9%, were considered in the numerical simulations. We, therefore, built: i) the historical scenario (2000–2019) with the current climate and redcedar cover leading to baseline results; ii) the most-likely future scenario (2020–2099) with projected climate (50^th percentile of aridity index distribution) and redcedar encroachment that was estimated by using a combination of neural network and Markov-chain cellular automata model; iii) 16 future scenarios (2020–2099) with different combinations of extreme climate (5^th and 95^th percentiles of aridity index distribution) and four hypothetical encroachment scenarios (0.5, 2.4, 4.6, and 11.9%). …”

Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions by Camila Oliveira da Silva (7365539)

“…The T2R triggering mechanisms and immune-inflammatory pathways involved in its pathology remain ill defined. In a recent report, we defined the recognition of nucleic acids by TLR9 as a major innate immunity pathway that is activated during T2R. …”

Supplementary Figure 1 from Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocar... by Edward J. Kim (14993765)

Stronger evidentiary standards do not reduce the need to publish negative outcomes by Silas Boye Nissen (6815351)

Performance w.r.t. Number of Realizations. by Ivan Komarov (120593)

“…<p>Both the strongly connected and the weakly connected systems show a decrease in time per update as the number of realizations is increased. …”

Regulation of spine neck resistance maintains local EPSP amplitude during synaptic plasticity. by Allan T. Gulledge (325673)

“…C) Plots of the decrease in spine neck resistance (% of control) required to preserve local EPSP amplitude following a 50% increase in AMPA conductance for spines with different initial spine neck resistances.…”

Light Stimulation Protocols. by Katherine E. Davis (534184)

“…The magnitude of this melanopsin step could be varied by mixing blue and yellow in the step (increasing the yellow and decreasing the blue elicited decreasing levels of contrast). …”

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells by Damodara Reddy Vaddi (467087)

“…The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. ER retention of hERG 125kDa form by CH was due to defective trafficking and was rescued by exposing cells to hypoxia at low temperatures or treatment with E-4031, a hERG channel blocker. …”

Childhood Obstructive Sleep Apnea Associates with Neuropsychological Deficits and Neuronal Brain Injury by Ann C Halbower (65065)

Investigation of <i>In Vacuo</i> Atomic Layer Deposition of Ultrathin MgAl₂O₄ Using Scanning Tunneling Spectroscopy by Ryan Goul (4352566)

“…Decreasing the number of supercycles from 3 (∼0.99 nm) to 1 supercycle (∼0.33 nm) resulted in a monotonic decrease in CBM from 1.71 to 1.49 eV, showing some frustration of growth during earlier atomic layer deposition cycles. …”

Protective effects of 20E against H₂O₂-induced cytotoxicity in B35 cells. by Jun Hu (5721)

“…Cells were pretreated with 20E (50 or 400 µM) for 24 h before a 12 h incubation with H₂O₂, and then LDH release (% of total) was calculated as the percentage of LDH in the medium versus total LDH activity in the cells. …”

Data_Sheet_1_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS... by Sayantan Sarkar (11975699)

“…A secondary objective was to undertake a genetic marker/quantitative trait locus (QTL) genetic analysis using the AgNO₃ phenotyping results. …”