Enzymatic Mechanism of Human Apurinic/Apyrimidinic Endonuclease against a THF AP Site Model Substrate by Sophia T. Mundle (303078)

“…There are estimates that this enzyme is responsible for eliminating as many as 10⁵ potentially mutagenic and genotoxic lesions from the genome of each cell every day. …”

Enzymatic Mechanism of Human Apurinic/Apyrimidinic Endonuclease against a THF AP Site Model Substrate by Sophia T. Mundle (303078)

“…There are estimates that this enzyme is responsible for eliminating as many as 10⁵ potentially mutagenic and genotoxic lesions from the genome of each cell every day. …”

Twenty-one gene panel and calculation of recurrence score by Laurel A Habel (20981)

“…The Recurrence Score, on a scale from 0 to 100, is derived from the reference-normalized expression measurements in four steps. In the first step the expression for each gene is normalized relative to the expression of the five reference genes (b-actin, GAPDH, GUS, RPLPO, and TFRC). …”

Quality controls for the TL high-throughput phenotyping approach. by Chenxi Qiu (706955)

“…(B) Additional growth conditions were employed to increase resolution for distinguishing similar TL alleles. Growth scores for 50 individually isolated TL mutants (y axis) under 12 growth conditions (x axis), as determined by standard serial dilution plate phenotyping (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006321#pgen.1006321.s004" target="_blank">S2</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006321#pgen.1006321.s005" target="_blank">S3</a> Figs), are shown as a heatmap. …”

Image_2_Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.jpeg by D. Elizabeth O'Hanlon (8552298)

“…We also compared the superficial cell index (SCI), a measure of cervicovaginal epithelial cell maturity, in no BV and aBV smears with relatively low numbers of shed cells (≤50/100X field). …”

Representative results of integrate-and-fire simulations for different learning rules. by Kendra S. Burbank (180062)

“…The arrows in the second subplot in <b>b–d</b> denote inflection points where the weights reached the boundaries and the standard deviation started to decrease. The parameters for each of these simulations are listed in the last column of <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002393#pcbi-1002393-t001" target="_blank"><b>Table 1</b></a>, with specifics as follows. …”

Table_1_Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.XLSX by D. Elizabeth O'Hanlon (8552298)

“…We also compared the superficial cell index (SCI), a measure of cervicovaginal epithelial cell maturity, in no BV and aBV smears with relatively low numbers of shed cells (≤50/100X field). …”

Image_1_Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.jpg by D. Elizabeth O'Hanlon (8552298)

“…We also compared the superficial cell index (SCI), a measure of cervicovaginal epithelial cell maturity, in no BV and aBV smears with relatively low numbers of shed cells (≤50/100X field). …”

Table_3_Heat in Wheat: Exploit Reverse Genetic Techniques to Discover New Alleles Within the Triticum durum sHsp26 Family.PDF by Alessia Comastri (5767751)

“…According to the last FAO report, a dramatic decrease in wheat production is expected in the next decades mainly due to the upcoming climate change. …”

Image_3_Heat in Wheat: Exploit Reverse Genetic Techniques to Discover New Alleles Within the Triticum durum sHsp26 Family.PDF by Alessia Comastri (5767751)

“…According to the last FAO report, a dramatic decrease in wheat production is expected in the next decades mainly due to the upcoming climate change. …”

Table_4_Metagenomic-based characterization of the gut virome in patients with polycystic ovary syndrome.XLSX by Liansha Huang (13252590)

“…</p>Results<p>The gut virome of PCOS patients exhibited a significant decrease in within-sample viral diversity and a remarkable alteration of the overall virome composition compared with that of healthy controls. …”

Dissolving microneedle patches for transdermal delivery of paroxetine: <i>in-vitro, ex-vivo</i> studies and its PBPK modeling by Muhammad Sikandar (13449684)

“…</p> <p>MNPs from the optimized formulation successfully created microchannels in rat skin, demonstrated higher permeation than control MNPs with a flux of 146.18 ± 13.42 µg/cm²/h, presented a decrease in lag phase and an increase in drug plasma C_max and AUC compared to PAXIL CR 12.5 mg oral, and showed higher stability in the room and refrigerator conditions.…”

Table_5_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.docx by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

Single stranded DNA extension analysis of MutL binding activity. by Jonghyun Park (237480)

“…<p>(<b>A</b>) A 5.3 kb ssDNA is coiled randomly at a stretching force of 2.5 pN. …”

Patterns of lake ice cover are changing throughout the Northern Hemisphere. by Alessandro Filazzola (6631649)

“…Depending on the greenhouse gas emissions, we predict a loss of between 50,000 and 200,000 km² of ice cover. …”

Slug controls mammosphere growth. by Mayssa Nassour (109073)

“…Microspheres and mammospheres were reported separately after 3 weeks. A significant decrease in viability was observed after 3 days in cells transfected with anti-Slug siRNA. …”

Table_2_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.DOCX by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

Validation of the model predictions for mES cell colony-forming efficiencies confirm enhanced self-renewal at reduced oxygen levels with GSK-3 inhibition. by Hélder S. C. Barbosa (158982)

“…Heat-maps show relative expression levels of key pluripotency genes (c), and colonies were stained for Nanog (d.1) or Oct4 (d.2) and nuclear marker DAPI (scale bar: 50 µm). The positive effects of GSK-3 inhibition could be correlated with a decrease in total and phosphorylated protein levels at 20% and 2% O₂ (e). …”

Supplementary Material for: Renoprotection by Continuous Erythropoietin Receptor Activator in Puromycin Aminonucleoside-Induced Nephrotic Syndrome by Aizawa K. (4135771)

“…<b><i>Background/Aims:</i></b> Recent studies have demonstrated that erythropoiesis-stimulating agents (ESAs) induce a tissue-protective effect in the kidney. In this study, we examined whether continuous erythropoietin receptor activator (CERA), a long-acting ESA, could prevent kidney injury, especially podocyte damage, in a rat model of nephrotic syndrome induced by puromycin aminonucleoside (PAN). …”

Influence of the conservation status on carbon balances of semiarid coastal Mediterranean wetlands by Daniel Morant (8748285)

“…Specifically, a highly altered site showed increased rates of aerobic respiration compared to undisturbed sites, with a decrease in C storage capacity to ∼50  g m⁻² yr⁻¹. …”