Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation by Kai-li Liu (11378101)

“…Furthermore, by western blot analysis, compound <b>8m</b> effectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. …”

Exploring the Impacts of Conformer Selection Methods on Ion Mobility Collision Cross Section Predictions by Felicity F. Nielson (10170218)

“…Based on our analyses, we found Boltzmann weighting to be a good trade-off between precision and theoretical accuracy. …”

Temporal and spatial variation of potassium balance in agricultural land at national and regional levels in China by Yingxia Liu (792213)

“…<div><p>Linking potassium (K) balance to soil fertility creates a valuable indicator for sustainability assessment in agricultural land-use systems. …”

Performance on discrimination and reversal tasks are similar for agents with one Q versus G and N matrices. by Kim T. Blackwell (10915047)

“…</b> Dynamics of G and N values for state <i>(Poke port</i>, <i>10 kHz)</i> for a single run. <b>F.</b> Dynamics of β₁ change according to recent reward history; thus, β₁ decreases at the beginning of discrimination, increases as the animal acquires the correct <i>right</i> response, and then decreases to the minimum at reversal. …”

Activation of the AMPK/mTOR signaling pathway correlates with curcumin-activated autophagy to restore D-gal-induced tight junction damage in SCs. by Chen Xue (699418)

Data_Sheet_1_Loud noise-exposure changes the firing frequency of subtypes of layer 5 pyramidal neurons and Martinotti cells in the mouse auditory cortex.docx by Ingrid Nogueira (15407156)

“…When comparing individual firing properties, noise exposure differentially affected type A and B PC firing frequency in response to depolarizing current steps. Specifically, type A PCs decreased initial firing frequency in response to +200 pA steps (p = 0.020) as well as decreased steady state firing frequency (p = 0.050) while type B PCs, on the contrary, significantly increased steady state firing frequency (p = 0.048) in response to a + 150 pA step 1 week after noise exposure. …”

Disrupting Glycolysis-promoting Genes Extends <i>C</i>. <i>elegans</i> Healthspan, Whereas High Glucose and Gluconeogenic Gene Disruptions Shorten Healthspan. by Brian Onken (86790)

“…On day 15, <i>fbp-1(RNAi)</i> decreases swimming rates by 44%, and <i>pck-2(RNAi)</i> animals moved too slowly to measure (or were dead) (marked as N/A). …”

Hemodynamic parameters. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

Tricuspid annular dimensions. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

Regional tricuspid annular perimeter. by Paulina Kania-Olejnik (19797617)

“…Anteroposterior diameter increased from 36.5±5.0mm to 38.4±5.5mm (<i>p</i> = 0.05). TA contraction decreased from 7±2% in SR to 2±1% in AF (p = 0.001). …”

DataSheet_1_Spliceostatin C, a component of a microbial bioherbicide, is a potent phytotoxin that inhibits the spliceosome.docx by Joanna Bajsa-Hirschel (3902302)

“…SPC inhibited the growth of Arabidopsis thaliana seedlings with an IC50 value of 2.2 µM. The seedlings exposed to SPC displayed a significant response with decreased root length and number and inhibition of gravitropism. …”

Effect of OP2113 on infarct size. by Dominique Detaille (3768979)

Emergence of Dynamic Instability by Hybridizing Synthetic Self-Assembled Dipeptide Fibers with Surfactant Micelles by Shogo Torigoe (13221476)

Chronic Exposure to Perfluorooctane Sulfonate Induces Behavior Defects and Neurotoxicity through Oxidative Damages, <i>In Vivo</i> and <i>In Vitro</i> by Na Chen (153323)

“…However, the neurotoxicity of PFOS and its mechanisms have not been fully elucidated. Using a combination of <i>in vivo</i> and <i>in vitro</i> methods, the present study provides a detailed description of PFOS-induced neurotoxicity. …”

Effects of functionalized multi-walled carbon nanotubes on toxicity and bioaccumulation of lead in <i>Daphnia magna</i> by Min-Hee Jang (827908)

“…The negatively charged C-MWCNT showed a notable decrease in lead toxicity (LC₅₀ value increased from 0.15 mg L^-1 to 1.08 mg L^-1 in the presence of 10 mg L^-1 C-MWCNT), whereas the positively charged N-MWCNT had only a slight effect on lead toxicity (LC₅₀ value increased from 0.15 mg L^-1 to 0.16 mg L^-1 in the presence of 10 mg L^-1 N-MWCNT). …”

Specific effects of OP2113 on ROS/H₂O₂ production at different sites in isolated rat heart mitochondria. by Dominique Detaille (3768979)

DataSheet1_Evaluation of the immune response of peripheral blood mononuclear cells cultured on Ti6Al4V-ELI polished or etched surfaces.pdf by Hugo Abreu (19815654)

“…</p>Methods<p>Ti6Al4V with extra low interstitial (ELI) content discs were treated with hydrofluoric acid followed by a controlled oxidation step in hydrogen peroxide that creates a complex surface topography with micro- and nano-texture and modifies the chemistry of the surface oxide layer. …”

The lack of an effect of OP2113 on mitochondrial oxidative phosphorylation. by Dominique Detaille (3768979)