Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis by Bongkochawan Pakamwong (12315428)

“…Models of complexes of compounds <b>G24</b> and <b>G26</b> bound to the M. tuberculosis DNA gyrase ATP-binding site, generated by molecular dynamics simulations followed by pharmacophore mapping analysis, showed hydrophobic interactions of inhibitor hydrophobic headgroups and electrostatic and hydrogen bond interactions of the polar tails, which are likely to be important for their inhibition. Decreasing compound lipophilicity by increasing the polarity of these tails then presents a likely route to improving the solubility and activity. …”

Fig 3 - by Masaru Sakai (1669627)

Immunoblot images of α-SMA, PCNA and Sirt1. by Hanhan Liu (568151)

Jag2 knockdown ameliorates mitochondrial dysfunction induced by hypoxia. by Hanhan Liu (568151)

Mutation prevalence of <i>podhfr</i>, <i>pocrt</i> and <i>pocytb</i> in <i>P</i>. <i>ovale curtisi</i> and <i>P</i>. <i>ovale wallikeri</i> isolates. by Jing Chen (4762)

Jag2 deficiency prevents proliferation and promotes apoptosis in hypoxia-treated PASMCs. by Hanhan Liu (568151)

Global effects of RG108 on DNA modifications and DNMTs and TETs enzymatic activities in hBMSCs. by Rahyza I. F. Assis (6037928)

“…(A) Global methylation was assessed using Imprint Methylated DNA Quantification Kit showing a significant decrease in the RG108 group. …”

The expected heterozygosity <i>(H</i>_<i>e</i>) of microsatellite loci flanking <i>podhfr</i> gene in <i>P</i>. <i>ovale curtisi</i>. by Jing Chen (4762)

Jag2 regulates mitochondrial injury in hypoxia-induced PASMCs via Sirt1 signaling. by Hanhan Liu (568151)

The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution by Jhih-Pu Lin (6321470)

“…Knock-down of 14-3-3η in Huh7 cells impaired and delayed the kinetics of MDA5 oligomerization, which is a critical step for MDA5 activation. …”

RNAi-based screen for genes that modify aSyn oligomerization in living cells. by Susana A. Gonçalves (199613)

“…</b> Representative live cell imaging pictures of aSyn-BiFC stable H4 cells silenced for hits that increase (<i>RAB8B</i>, <i>RAB11A</i>, <i>RAB13</i>, <i>RAB39B</i>, <i>CAMK1</i>, <i>DYRK2</i>) or decrease (<i>CC2D1A</i>, <i>CLK4</i>, <i>SYTL5)</i> aSyn oligomerization (green). …”

Lakes in Europe harbour more anthropogenic microparticles than elsewhere. by Andrew J. Tanentzap (10227764)

Single-Crystalline Mo-Nanowire-Mediated Directional Growth of High-Index-Faceted MoNi Electrocatalyst for Ultralong-Term Alkaline Hydrogen Evolution by Zhenpeng Liu (9179175)

“…When the as-achieved Mo@MoNi core–shell nanowire film serve as a free-standing cathode in alkaline solutions, it exhibit a remarkably decreased HER overpotential of 18 mV at 10 mA cm^–2 and a Tafel slope of ∼33 mV dec^–1, which are much lower than those for the state-of-the-art earth-abundant electrocatalysts and even commercial Pt/C. …”

RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5 by Julie J. Loiselle (4183750)

“…Interestingly, the earliest and most frequent genetic alteration associated with lung cancers involves a lesion in the region to which the RNA binding protein <i>RBM5</i> maps. We have recently shown that a decrease in <i>RBM5</i> expression may be a key step in SCLC development, as RBM5 regulated many transformation-associated processes in SCLC cells. …”

Cardiac Contractility Structure-Activity Relationship and Ligand-Receptor Interactions; the Discovery Of Unique and Novel Molecular Switches in Myosuppressin Signaling by Megan Leander (459603)

“…Further, these motifs were present in red flour beetle, common water flea, honey bee, domestic silkworm, and termite MS-Rs. RhpMS and DrmMS decreased <i>R</i>. <i>prolixus</i> cardiac contractility dose dependently with EC₅₀ values of 140 nM and 50 nM. …”

Intracellular pH of <i>C</i>. <i>albicans</i> ATCC 90028; FLC-susceptible <i>C</i>. <i>albicans</i> D27and FLC-resistant <i>C</i>. <i>albicans</i> D15.9 with and without the treatm... by Mohammad Irfan (464459)

Linear mixed model results: Effect of bar height and approach stride number on sagittal joint kinematics at take-off to a jump in agility dogs. by Leena Inkilä (20614460)

Influence of pre-treatment blood pressure levels on antihypertensive drug benefits in diabetics: the roadmap experience by Christos Chatzikyrkou (2792542)

The inactivation of <i>Kdm6a</i> in mice had age- and gender-dependent effects on normal hematopoiesis. by Ling Tian (107492)

LV function and geometry: Exercise cohort. by Stephanie L. Samani (17896610)

“…Additionally, miR-22 and miR-30e decreased with exercise and mapped to a localized inflammatory process, the inflammasome (NLRP-3, whereby a 2-fold decrease in NLRP-3 mRNA occurred with exercise (p < 0.05).…”