Showing 6,181 - 6,200 results of 29,970 for search '(( 5 step decrease ) OR ( 50 ((((we decrease) OR (mean decrease))) OR (a decrease)) ))', query time: 1.16s Refine Results
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    Cyclization Decoded: Engineering Amylomaltase for Efficient α‑Glucan Transformations by Han Liu (288039)

    Published 2025
    “…Here, we harness large-scale computations in synergy with biochemical experiments to unravel, at atomic resolution, the full covalent and noncovalent catalytic mechanism of AMs, revealing that cyclization (12.8 kcal/mol) outcompetes hydrolysis (17.5 kcal/mol) as the dominant pathway. Furthermore, we identify that postglycosylation noncovalent polysaccharide chain transfer emerges as the decisive factor in cyclization, particularly for AM–degree of polymerization (DP) greater than 30 substrate complexes, where this noncovalent step (≥13.6 kcal/mol) dictates the rate of CA production. 57 variants with enhanced activity (up to a 2.3-fold increase) were engineered in our biochemical experiments by strategically modulating the chain transfer step. …”
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    Knockdown of CRT suppressed VEGF-A expression and mRNA stability through ARE in AGS cells. by Po-Chu Lee (438366)

    Published 2019
    “…VEGF-A mRNA was significantly less stable in the CRT-knockdown cells with lower half-life and 50% mRNA remaining time. …”
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    Effect of MNC hUCB cell administration on microglial cell density in the spinal cord of G93A mice. by Svitlana Garbuzova-Davis (81764)

    Published 2013
    “…A) In the cervical spinal cord, mice receiving 10×10<sup>6</sup> MNC hUCB cells showed significantly (p<0.001) higher microglial cell density vs. mice with 25×10<sup>6</sup> and 50×10<sup>6</sup> cell doses. …”