Trichopsistides A and B: Two Highly Oxygenated Pentacyclic Polyketides with Promising Inhibitory Effects on the NF-κB Signaling Pathway from the Fungus <i>Trichoderma koningiopsis<... by Li Feng (77923)

“…Two highly oxygenated pentacyclic polyketides with two new carbon skeletons, trichopsistide A (<b>1</b>) and trichopsistide B (<b>2</b>), were isolated from the plant endophyte <i>Trichoderma koningiopsis</i> WZ-196 derived from the leaf of <i>Rubia podantha</i> Diels. …”

Fig 3 - by Debarpan Dhar (724473)

Machine learning models and univariate analyses discriminating non-severe and severe COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Machine learning models and univariate analyses discriminating HC from non-severe COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Machine learning models and univariate analyses discriminating severe and critical COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Discovery of PMSA Derivative <b>11</b> as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis <i>In Vitro</i> and <i>In Vivo</i> by Zhihao Chen (513264)

“…Additionally, <b>11</b> blocked the formation of F-action belts and bone resorption in a concentration-dependent manner. Mechanistically, <b>11</b> decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation from the cytoplasm to nucleus. …”

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

α‑CsCu₅Se₃: Discovery of a Low-Cost Bulk Selenide with High Thermoelectric Performance by Ni Ma (676167)

“…In compariosn to the isostructural CsAg₅Te₃, α-CsCu₅Se₃ shows a 30% volume decrease that leads to stronger orbital overlapping that markedly decreases the band effective mass (<i>m</i>*). …”

α‑CsCu₅Se₃: Discovery of a Low-Cost Bulk Selenide with High Thermoelectric Performance by Ni Ma (676167)

“…In compariosn to the isostructural CsAg₅Te₃, α-CsCu₅Se₃ shows a 30% volume decrease that leads to stronger orbital overlapping that markedly decreases the band effective mass (<i>m</i>*). …”

α‑CsCu₅Se₃: Discovery of a Low-Cost Bulk Selenide with High Thermoelectric Performance by Ni Ma (676167)

“…In compariosn to the isostructural CsAg₅Te₃, α-CsCu₅Se₃ shows a 30% volume decrease that leads to stronger orbital overlapping that markedly decreases the band effective mass (<i>m</i>*). …”

Simvastatin alters actin organization, cell morphology, and Rac1 activity in endothelial monolayers. by Marsha C. Lampi (845609)

“…Cell circularity, where a perfectly circular cell has a value of 1, decreases with increasing simvastatin concentration (n = 3, 50–54 cells per condition). …”

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 by Marta E. Capala (652765)

“…Downregulation of SAM50 also impaired the proliferation and replating capacity of BCR-ABL-expressing cells, again associated with a decreased mitochondrial membrane potential. …”

Table_1_Guanidine acetic acid exhibited greater growth performance in younger (13–30 kg) than in older (30–50 kg) lambs under high-concentrate feedlotting pattern.docx by Wen-Juan Li (1444948)

“…In a brief, the results obtained in the present study suggested that GAA (UGAA and CGAA; 1 g/kg DM) could be applied to improve growth performance in younger (13–30 kg) instead of older (30–50 kg) lambs in high-concentrate feedlotting practice.…”

Effects of ROCK inhibitors H-1152 and Y-27632 on TNF-induced MLC phosphorylation, actin and CL5 reorganization and the fall in TEER. by Paul R. Clark (714064)

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger - Fig 2 by Andrea Szentesi (3239193)

Analysis of requirement for MYPT1 expression in TNF-induced MLC phosphorylation and leak. by Paul R. Clark (714064)

Box plot displaying the distributions of the deconvolution derived proportions of cell types. by Arttu Autio-Kimura (20454681)

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles <i>in vitro</i> - Fig 4 by Remo Campiche (3714208)

“…Hair follicles treated with lower concentrations of Gambogic Amide kept their anagen-like appearance. Bars = 50 μm. <b>E: Immunohistochemical quantification of melanocytes with p16, a marker for mature and senescent melanocytes</b>. …”

IFN-γ counter-regulates hepatic fetuin-A expression. by Wei Li (7081)

“…<p><b>A</b>). <i>IFN-γ decreased fetuin-A expression levels in hepatocytes</i>. …”

Overlayed expression profiles of cyclins A2 and B1. by James W. Jacobberger (184625)