Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resis... by Zhikun Liu (389939)

“…Among them, compound <b>29</b> showed the most potent antitumor activity in vitro with IC₅₀ values at the nanomolar level against the tested tumor cell lines and 1000-fold higher than cisplatin against the multidrug resistant cells (A549/CDDP, A549/DOX, and SKOV-3/CDDP cells), while it showed only moderate cytotoxicity against normal cells (HEUVC cells). …”

Validation of selected genes associated with p53 connection pathway was carried out using quantitative real-time polymerase chain reaction (qRT-PCR) and western immunoblotting. by Mei Yi Sim (4067998)

Tuning Magnetic and Structural Transitions through Valence Electron Concentration in the Giant Magnetocaloric Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ Phases by Jinlei Yao (1712740)

“…A decrease in the valence electron concentration achieved through the substitution of Eu²⁺ for Gd³⁺ leads to the formation of the interslab Ge–Ge dimers, phase transitions to the Gd₅Si₂Ge₂- and Gd₅Si₄-type structures, and a ferromagnetic ordering in the Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ system. …”

Data_Sheet_5_Comprehensive Quantitative Proteome Analysis of Aedes aegypti Identifies Proteins and Pathways Involved in Wolbachia pipientis and Zika Virus Interference Phenomenon.P... by Michele Martins (6431450)

Contrast modulates the cone frequency response—sum of sinusoids (SoS) stimuli. by Marcus H. C. Howlett (3921143)

(A) Growth of <i>M</i>. <i>smegmatis ΔFtsEX</i> cells with rifampicin [350 μg/ml] with the time interval between consecutive microdialysis steps doubled to 2 hours—across the vario... by Brilliant B. Luthuli (785964)

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

DataSheet1_Zebrafish EEG predicts the efficacy of antiepileptic drugs.pdf by Jun-Nyeong Shin (14234054)

“…We propose a novel method for pharmacological evaluation of AEDs based on EEG from adult zebrafish, which allows researchers to select more clinically valuable drugs at the early stage of AED screening.…”

Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma by Bo Li (112195)

“…Herein, we report the structure-guided development of a series of covalent inhibitors of FAK. …”

BRSV RNA detected in nasal swabs of cows that were naturally re-infected four years after a previous natural BRSV infection (n = 7, reinfection) and cows that were naturally infect... by Sara Hägglund (580500)

Exploring the Impacts of Conformer Selection Methods on Ion Mobility Collision Cross Section Predictions by Felicity F. Nielson (10170218)

“…Based on our analyses, we found Boltzmann weighting to be a good trade-off between precision and theoretical accuracy. …”

Solvent accessible surface area. by Jingran Wen (4047724)

Solvent-polyQ hydrogen bond count. by Jingran Wen (4047724)

Table_11_Tramadol’s Inhibitory Effects on Sexual Behavior: Pharmacological Studies in Serotonin Transporter Knockout Rats.PDF by Diana C. Esquivel-Franco (5455082)

Solvent-polyQ hydrogen bond count at the atomic level. by Jingran Wen (4047724)

Intra-polyQ hydrogen bonding. by Jingran Wen (4047724)

Data_Sheet_3_Exploring the active ingredients and pharmacological mechanisms of the oral intake formula Huoxiang Suling Shuanghua Decoction on influenza virus type A based on netwo... by Ruying Tang (14036640)