DataSheet1_Improving glycemic control: transitioning from dulaglutide to tirzepatide in patients with type 2 diabetes undergoing hemodialysis.zip by Emiko Otsuka (7519313)

“…After switching to tirzepatide, time in range increased to 50.8% from 42.7% (p = 0.02), time above range decreased to 37.8% from 48.4% (p = 0.02), and mean glucose levels decreased to 137.4 mg/dL from 156.6 mg/dL (p = 0.006). …”

Synthesis and Electron Spin Relaxation of Tetracarboxylate Pyrroline Nitroxides by Shengdian Huang (1534051)

“…The key step in the synthesis of <b>1</b> and <b>2</b> is the reaction of the dianion of pyrrole-1,2,5-tricarboxylic acid <i>tert</i>-butyl ester dimethyl ester with electrophiles such as methyl chloroformate and methyl bromoacetate. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…We have investigated conformational transitions in the Klenow fragment polymerase reaction by stopped-flow fluorescence using DNA substrates containing the fluorescent reporter 2-aminopurine (2-AP) on the template strand, either at the templating position opposite the incoming nucleotide (designated the 0 position) or 5‘ to the templating base (the +1 position). By using both deoxy- and dideoxy-terminated primers, we were able to distinguish steps that accompany ternary complex formation from those that occur during nucleotide incorporation. …”

p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies by Pooja Lahiri (533520)

“…Upon recovery from DDC intoxication on a standard diet, there was an enhanced reduction of p62-deficient MDBs, which was accompanied by a pronounced decrease in ubiquitinated proteins. Our data provide strong evidence that keratin aggregation is the initial step in MDB formation in steatohepatitis-related mouse models. …”

An Inducible Cell-Cell Fusion System with Integrated Ability to Measure the Efficiency and Specificity of HIV-1 Entry Inhibitors by Alon Herschhorn (198447)

“…<div><p>HIV-1 envelope glycoproteins (Envs) mediate virus entry by fusing the viral and target cell membranes, a multi-step process that represents an attractive target for inhibition. …”

Data_Sheet_1_Biochemical, Metabolomic, and Genetic Analyses of Dephospho Coenzyme A Kinase Involved in Coenzyme A Biosynthesis in the Human Enteric Parasite Entamoeba histolytica.P... by Arif Nurkanto (6032693)

“…In the protozoan parasite Entamoeba histolytica, CoA is synthesized in a pathway consisting of four enzymes with dephospho-CoA kinase (DPCK) catalyzing the last step. However, the metabolic and physiological roles of E. histolytica DPCK remain elusive. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…We have investigated conformational transitions in the Klenow fragment polymerase reaction by stopped-flow fluorescence using DNA substrates containing the fluorescent reporter 2-aminopurine (2-AP) on the template strand, either at the templating position opposite the incoming nucleotide (designated the 0 position) or 5‘ to the templating base (the +1 position). By using both deoxy- and dideoxy-terminated primers, we were able to distinguish steps that accompany ternary complex formation from those that occur during nucleotide incorporation. …”

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)^† by Vandana Purohit (2947848)

“…We have investigated conformational transitions in the Klenow fragment polymerase reaction by stopped-flow fluorescence using DNA substrates containing the fluorescent reporter 2-aminopurine (2-AP) on the template strand, either at the templating position opposite the incoming nucleotide (designated the 0 position) or 5‘ to the templating base (the +1 position). By using both deoxy- and dideoxy-terminated primers, we were able to distinguish steps that accompany ternary complex formation from those that occur during nucleotide incorporation. …”

Data_Sheet_2_Biochemical, Metabolomic, and Genetic Analyses of Dephospho Coenzyme A Kinase Involved in Coenzyme A Biosynthesis in the Human Enteric Parasite Entamoeba histolytica.P... by Arif Nurkanto (6032693)

“…In the protozoan parasite Entamoeba histolytica, CoA is synthesized in a pathway consisting of four enzymes with dephospho-CoA kinase (DPCK) catalyzing the last step. However, the metabolic and physiological roles of E. histolytica DPCK remain elusive. …”

Synthesis and Electron Spin Relaxation of Tetracarboxylate Pyrroline Nitroxides by Shengdian Huang (1534051)

“…The key step in the synthesis of <b>1</b> and <b>2</b> is the reaction of the dianion of pyrrole-1,2,5-tricarboxylic acid <i>tert</i>-butyl ester dimethyl ester with electrophiles such as methyl chloroformate and methyl bromoacetate. …”

Inhibition of cellular proliferation and induction of cell cycle arrest by PEG-8000 in SCC-25 cells- SCC-25 cells were treated with different concentrations of PEG-8000 for 24 h an... by Ramesh K. Wali (305603)

“…<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038047#pone-0038047-g004" target="_blank">Figure 4B</a> shows a ∼50% decrease on the expression of proliferation marker PCNA by PEG. …”

Effect of Ligand Modulation on Metal-to-Metal Electron Transfer in a Series of [Fe₂Co₂] Molecular Square Complexes by Sujit Kamilya (8810441)

“…Magnetic studies reveal that all three complexes exhibit temperature-induced metal-to-metal electron transfer (MMET) from a high-spin Co­(II) center to a low-spin Fe­(III) center, transforming a high-temperature paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a low-temperature diamagnetic {Fe^II_LS–CN–Co^III_LS} state with a decrease in the temperature from 300 to 100 K. Complexes <b>1</b> and <b>3</b> show the interconversion of the paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a diamagnetic {Fe^II_LS-CN-Co^III_LS} state in a single-step transition with <i>T</i>_1/2 values of 180 and 186 K, respectively, while a two-step MMET with <i>T</i>_1/2 value of 214 and 178 K was observed for complex <b>2</b>.…”

Effect of Ligand Modulation on Metal-to-Metal Electron Transfer in a Series of [Fe₂Co₂] Molecular Square Complexes by Sujit Kamilya (8810441)

“…Magnetic studies reveal that all three complexes exhibit temperature-induced metal-to-metal electron transfer (MMET) from a high-spin Co­(II) center to a low-spin Fe­(III) center, transforming a high-temperature paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a low-temperature diamagnetic {Fe^II_LS–CN–Co^III_LS} state with a decrease in the temperature from 300 to 100 K. Complexes <b>1</b> and <b>3</b> show the interconversion of the paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a diamagnetic {Fe^II_LS-CN-Co^III_LS} state in a single-step transition with <i>T</i>_1/2 values of 180 and 186 K, respectively, while a two-step MMET with <i>T</i>_1/2 value of 214 and 178 K was observed for complex <b>2</b>.…”

Effect of Ligand Modulation on Metal-to-Metal Electron Transfer in a Series of [Fe₂Co₂] Molecular Square Complexes by Sujit Kamilya (8810441)

“…Magnetic studies reveal that all three complexes exhibit temperature-induced metal-to-metal electron transfer (MMET) from a high-spin Co­(II) center to a low-spin Fe­(III) center, transforming a high-temperature paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a low-temperature diamagnetic {Fe^II_LS–CN–Co^III_LS} state with a decrease in the temperature from 300 to 100 K. Complexes <b>1</b> and <b>3</b> show the interconversion of the paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a diamagnetic {Fe^II_LS-CN-Co^III_LS} state in a single-step transition with <i>T</i>_1/2 values of 180 and 186 K, respectively, while a two-step MMET with <i>T</i>_1/2 value of 214 and 178 K was observed for complex <b>2</b>.…”

Only 52 of the 256 possible genotypes between PfCRT^3D7 and the CQ-transporting PfCRT^Dd2 isoform have measured phenotypes. by Zachary R. Sailer (4025459)

“…This trajectory passes through the PfCRT^{China e} and PfCRT^K1 isoforms. Five of the eight steps increase CQ transport activity, two have no effect, and the final step causes a decrease.…”

Effect of Ligand Modulation on Metal-to-Metal Electron Transfer in a Series of [Fe₂Co₂] Molecular Square Complexes by Sujit Kamilya (8810441)

“…Magnetic studies reveal that all three complexes exhibit temperature-induced metal-to-metal electron transfer (MMET) from a high-spin Co­(II) center to a low-spin Fe­(III) center, transforming a high-temperature paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a low-temperature diamagnetic {Fe^II_LS–CN–Co^III_LS} state with a decrease in the temperature from 300 to 100 K. Complexes <b>1</b> and <b>3</b> show the interconversion of the paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a diamagnetic {Fe^II_LS-CN-Co^III_LS} state in a single-step transition with <i>T</i>_1/2 values of 180 and 186 K, respectively, while a two-step MMET with <i>T</i>_1/2 value of 214 and 178 K was observed for complex <b>2</b>.…”

Effect of Ligand Modulation on Metal-to-Metal Electron Transfer in a Series of [Fe₂Co₂] Molecular Square Complexes by Sujit Kamilya (8810441)

“…Magnetic studies reveal that all three complexes exhibit temperature-induced metal-to-metal electron transfer (MMET) from a high-spin Co­(II) center to a low-spin Fe­(III) center, transforming a high-temperature paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a low-temperature diamagnetic {Fe^II_LS–CN–Co^III_LS} state with a decrease in the temperature from 300 to 100 K. Complexes <b>1</b> and <b>3</b> show the interconversion of the paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a diamagnetic {Fe^II_LS-CN-Co^III_LS} state in a single-step transition with <i>T</i>_1/2 values of 180 and 186 K, respectively, while a two-step MMET with <i>T</i>_1/2 value of 214 and 178 K was observed for complex <b>2</b>.…”

Effect of Ligand Modulation on Metal-to-Metal Electron Transfer in a Series of [Fe₂Co₂] Molecular Square Complexes by Sujit Kamilya (8810441)

“…Magnetic studies reveal that all three complexes exhibit temperature-induced metal-to-metal electron transfer (MMET) from a high-spin Co­(II) center to a low-spin Fe­(III) center, transforming a high-temperature paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a low-temperature diamagnetic {Fe^II_LS–CN–Co^III_LS} state with a decrease in the temperature from 300 to 100 K. Complexes <b>1</b> and <b>3</b> show the interconversion of the paramagnetic {Fe^III_LS–CN–Co^II_HS} ground state into a diamagnetic {Fe^II_LS-CN-Co^III_LS} state in a single-step transition with <i>T</i>_1/2 values of 180 and 186 K, respectively, while a two-step MMET with <i>T</i>_1/2 value of 214 and 178 K was observed for complex <b>2</b>.…”

10% foetal bovine serum in RPMI 1640 medium is able to induce a substantial portion of spermatid differentiation <i>in vitro</i>. by Yonggang Lu (358237)

“…<p>After 36 h of incubation in this culture medium, the percentage of step 1–3 spermatids decreases from 10% to 0% while that of step 7–9 spermatids increases from 28% to 39.3%. …”

Data Sheet 1_Concurrent training and intermittent fasting reduce transverse cross-sectional area of cardiomyocytes and body mass in Wistar rats.pdf by Henrique Izaias Marcelo (21810809)

“…</p>Conclusion<p>The practice of concurrent training for a period of 4 weeks precipitated a decrease in the transverse cross-sectional area of the cardiomyocytes of Wistar rats. …”