Image_5_Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ.jpg by Tatyana Veremeyko (394702)

Association of Long-Term Change and Variability in Glycemia with Risk of Incident Heart Failure among Patients with Type 2 Diabetes Mellitus – A Secondary Analysis of the ACCORD Tr... by Matthew W. Segar (8816108)

Protons cause a greater increase in persistent sodium current in C373F/E1784K Na_V1.5. by Colin H. Peters (4430245)

“…The E1784K mutant increases the fraction of charge which recovers with the fast time constant of recovery and decreases the fraction of slow charge return. (<b>F <i>inset</i></b>) To measure the rate of gating current deactivation, we depolarized cells to 0mV (c) following a conditioning pulse to 0mV (a) and a recovery pulse of variable length to -150mV (b).…”

Image_2_MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36.tif by Xin Wang (91924)

“…However, under the condition of interference with CD36, further inhibition of miR-20a-5p would not cause lipid over-accumulation. In this study, we found that miR-20a-5p played a protective role in lipid metabolic disorders of NAFLD by targeting CD36, which indicated the prospect of miR-20a-5p as a biomarker and treatment target for NAFLD.…”

Image_1_MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36.TIF by Xin Wang (91924)

“…However, under the condition of interference with CD36, further inhibition of miR-20a-5p would not cause lipid over-accumulation. In this study, we found that miR-20a-5p played a protective role in lipid metabolic disorders of NAFLD by targeting CD36, which indicated the prospect of miR-20a-5p as a biomarker and treatment target for NAFLD.…”

Image_3_MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36.TIF by Xin Wang (91924)

“…However, under the condition of interference with CD36, further inhibition of miR-20a-5p would not cause lipid over-accumulation. In this study, we found that miR-20a-5p played a protective role in lipid metabolic disorders of NAFLD by targeting CD36, which indicated the prospect of miR-20a-5p as a biomarker and treatment target for NAFLD.…”

AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes by Shi-Ying Yuan (2937669)

“…Glucocorticoid-induced effects were attenuated by glucocorticoid-inducible kinase 1 (SGK1) inhibitor GSK650394, which also inhibited glucocorticoid induced phosphorylation of Forkhead box O3a (FOXO3a). Furthermore, glucocorticoid-induced down-regulation of GR was mimicked by the inhibition of AMPK and abolished by the AMPK activators or the histone deacetylase 5 (HDAC5) inhibitors. …”

Image1_Dynamic stability during level walking and obstacle crossing in children aged 2–5 years estimated by marker-less motion capture.jpeg by Kohei Yoshimoto (4776570)

“…In the lateral direction, children exhibited a greater MoS than adults during level walking [children: 9.5%, adults: 6.5%, median, W = 39.000, p < .001, rank-biserial correlation = −0.684]; however, some children exhibited a smaller MoS during obstacle crossing [lead leg: −5.9% to 3.6% (min–max) for 4 children, 4.7%–6.4% [95% confidence interval (CI)] for adults, p < 0.05; trail leg: 0.1%–4.4% (min–max) for 4 children, 4.7%–6.4% (95% CI) for adults, p < 0.05]]. …”

Video_2_Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.AVI by Jian-Wei Zhu (285977)

“…In addition, deficiency of TRIM32 decreased Type I inositol 1,4,5-trisphosphate 5-phosphatase (INPP5A) levels in cerebellum. …”

Video_3_Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.AVI by Jian-Wei Zhu (285977)

“…In addition, deficiency of TRIM32 decreased Type I inositol 1,4,5-trisphosphate 5-phosphatase (INPP5A) levels in cerebellum. …”

Image_2_Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.TIF by Jian-Wei Zhu (285977)

“…In addition, deficiency of TRIM32 decreased Type I inositol 1,4,5-trisphosphate 5-phosphatase (INPP5A) levels in cerebellum. …”

Image_1_Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.TIF by Jian-Wei Zhu (285977)

“…In addition, deficiency of TRIM32 decreased Type I inositol 1,4,5-trisphosphate 5-phosphatase (INPP5A) levels in cerebellum. …”

Video_1_Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.AVI by Jian-Wei Zhu (285977)

“…In addition, deficiency of TRIM32 decreased Type I inositol 1,4,5-trisphosphate 5-phosphatase (INPP5A) levels in cerebellum. …”

Zero-loss and low-loss EELS spectra of water vapor at various pressures (300kV, room temperature). by Cathal Cassidy (1758703)

“…Zero-loss peak intensity decreases, and energy loss intensity increases, as a function of water vapor pressure, as expected. …”

Data_Sheet_5_Personalized surgical planning for coronary bypass graft configurations using patient-specific computational modeling to avoid flow competition in arterial grafts.XLSX by Krish Chaudhuri (13866956)

“…The use of the computational models led to a significant decrease in the selection of unsatisfactory grafting configurations when surgeons employed “anaortic” (21.25% (17/80) vs. 1.25% (1/80), P < 0.001) but not “aortic” techniques (5% (4/80) vs. 0% (0/80), P = 0.64). …”

Data_Sheet_5_Personalized surgical planning for coronary bypass graft configurations using patient-specific computational modeling to avoid flow competition in arterial grafts.XLSX by Krish Chaudhuri (13866956)

“…The use of the computational models led to a significant decrease in the selection of unsatisfactory grafting configurations when surgeons employed “anaortic” (21.25% (17/80) vs. 1.25% (1/80), P < 0.001) but not “aortic” techniques (5% (4/80) vs. 0% (0/80), P = 0.64). …”

Excel sheet summarizing mutations across different continually passaged virus populations in comparison to SARS-CoV-2 _Wuhan-1 (MN908947) and SARS-CoV-2_Engl2. by Agnieszka M. Szemiel (10196243)

Early prenatal alcohol exposure alters imprinted gene expression in placenta and embryo in a mouse model by Heidi Marjonen (738402)

“…To clarify the molecular mechanisms of PAE we have used a mouse model of early alcohol exposure, which is based on maternal <i>ad libitum</i> ingestion of 10% (v/v) ethanol for the first eight days of gestation (GD 0.5–8.5). …”

PSMC5 regulation of FosB/ΔFosB expression in Rat 1A cells. by Yoko H. Ohnishi (737351)

“…<p>A. Rat 1A cells were transfected with 4 μg of PSMC5 or control DNA. …”

JMJD5 forms a complex with CRY1–FBXL3 and leads to CRY1 degradation. by Anand R. Saran (6034127)

“…(D) Knockdown of FBXL3 decreases JMJD5 co-IP with CRY1. Densitometric analysis showing ratio of JMJD5 to CRY1 signals from these experiments (mean ± SEM, <i>n</i> = 4) are shown in (E). …”