The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice by Tatsuya Shimomatsu (1545943)

“…<p><i>Objectives</i>: To evaluate the effect and safety of hydroxychloroquine (HCQ) on lupus erythematosus (LE)-like skin lesions in the MRL/lpr mouse, a model for systemic LE (SLE).</p> <p><i>Methods</i>: We divided the MRL/lpr mice into three groups that were given: (1) drinking water, (2) HCQ at a dose of 4 mg/kg/d, or (3) HCQ at a dose of 40 mg/kg/d. …”

DataSheet1_Investigation of Chromosomal Structural Abnormalities in Patients With Undiagnosed Neurodevelopmental Disorders.docx by Ye Cao (849948)

“…</p><p>Method: In this study, we applied the mate-pair low pass (∼4X) genome sequencing with large DNA-insert (∼5 kb) in a cohort of 100 patients with neurodevelopmental disorders who did not receive informative results from a routine CNV investigation. …”

QUANTIFICATION OF CRAMBE BIODIESEL CONTENT IN DIESEL BLENDS USING MIR SPECTROSCOPY END VARIABLES SELECTION. by Lucas G. da Costa (10380736)

“…In order to develop a non-destructive method, being possible to recover the sample after its quantification, decrease the quantity of samples and make use of a single calibration curve, in this study we used the oilseed crambe, which is not used in human food, for the methyl biodiesel production and PLS analysis for their content determination in mixtures with diesel at a concentration range of 1.00 to 30.00 (% v/v). …”

DataSheet1_Non-Arrhenian Temperature-Dependent Viscosity of Alkali(ne) Carbonate Melts at Mantle Pressures.PDF by Xenia Ritter (11568316)

“…Pressure is found to have a much more moderate effect on the viscosity of alkali(ne) carbonate melts, with activation volumes V_a that decrease from 4.5 to 1.9 cm³/mol between 1,300 and 2,000 K. …”

Effects of LPS stimulation with and without additional thrombin-driven activation of the coagulation system. by Doreen Tabea Spiegelburg (14419858)

“…<p>Human whole blood was incubated for 30 min with either PBS (Control) or 100 ng/mL LPS plus or minus 0.5 U/mL thrombin (LPS and LPS + Thr, respectively). …”

GlVps depletion affects AcPh localization and activity. by Maria R. Rivero (141332)

“…<p>(A) Bars indicate densitometric assessment of one representative RT-PCR experiment using 10 ng of total RNA from <i>GlVps-antisense</i> (AS) and <i>empty</i> (Ctrol) transgenic trophozoites. …”

Leptin alone and in combination with interleukin-1-beta induced cartilage degradation potentially inhibited by EPA and DHA by Thanyaluck Phitak (4518742)

“…Increased leptin has been the focus of a link between obesity and OA. In this study, the effects of pathological (100ng/ml) or supra-pathological (10μg/ml) concentrations of leptin alone or in combination with IL1β on cartilage metabolisms were studied in porcine cartilage explant. …”

Extensive Natural Variation for Cellular Hydrogen Peroxide Release Is Genetically Controlled by Homa Attar (138799)

“…We found 5 significant associations (p<5.00×10−8) and 54 suggestive associations (p<1.00×10−5), one of which confirmed the linked region on Hsa15. …”

Constraint on the eclogite age of the Sanbagawa metamorphic rocks in central Shikoku, Japan by Shogo Aoki (6440666)

“…The detrital igneous cores of the zircons show ages from ca. 2000 to 100 Ma, and the metamorphic rims show ca. 90 Ma. …”

Colombian Ocular Inflammatory Diseases Epidemiology Study (COIDES): Prevalence, Incidence, and Sociodemographic Characterization of Uveitis in Colombia, 2015-2020 by Gabriela Florez-Esparza (17404252)

“…In 2020, there was a noticeable decrease in the incidence and prevalence of GU. …”

Effect of AAS27 and AAS41 cocktail on expression of pro-inflammatory and anti-inflammatory cytokines by MΦ that were first activated with LPS or cocktail of r<i>Aam</i>IGFBP-rP1, r... by Mariam Bakshi (7962230)

“…Day 1 = 24 h incubation with 100 ng LPS or PI-rTSPs cocktail; Day 2 = Following 24 h with LPS or PI-rTSPs cocktail, removal of media and additional 24 h incubation with AI-rTSPs cocktail. …”

miR-206 targets TIMP-3. by Federica Limana (216501)

“…Cells were transfected with anti-miR206 and exposed to hypoxia for 24 hr either in the presence or in the absence of 100 ng/ml HMGB1. For western blot analysis (B,C), the same filter was probed with α-tubulin to normalize protein loading. …”

ORP8 KO BMDMs have reduced excretion of pro-inflammatory cytokines and reduced expression of co-stimulatory factors. by Erik van Kampen (649704)

“…<p>Bone Marrow-Derived Macrophages (BMDMs) were generated from bone marrow of ORP8 KO mice or WT controls and stimulated with LPS (100 ng/mL). A) A decrease in secretion of IL-6 by LPS stimulated ORP8 KO BMDMs was measured using ELISA. (** P<0.01, N = 4) B) Similarly, TNFα secretion was also decreased in LPS-stimulated ORP8 KO BMDMs. (* P<0.05, N = 4). …”

In microglia, C1 reduced NO release triggered by IFNγ and PolyIC, and did not affect LPS induced cytokine release. by Philipp Jordan (9364068)

“…<p><b>a)</b> Stimulation of microglia with IFNγ (100 ng/mL) for 48 hours (left, in black) and PolyIC (100 μg/mL) for 24 hours (right, in black) caused a significant increase in the production of NO (p<0.0001) in comparison with unstimulated control (white bar). …”

Extending the information content of the MALDI analysis of biological fluids via multi-million shot analysis by Maxim Tsypin (6841484)

“…</p><p>Methods</p><p>To assess what is theoretically achievable we utilized spectra from the same samples obtained over many years and combined them to generate MALDI spectral averages of up to 100,000,000 shots for a single sample, and up to 8,000,000 shots for a set of 40 different serum samples. …”

Table_1_Exogenous γ-aminobutyric acid (GABA) mitigated salinity-induced impairments in mungbean plants by regulating their nitrogen metabolism and antioxidant potential.docx by Abd Ullah (6529958)

“…However, it remains largely unknown how mungbean plants (Vigna radiata L.) respondto exogenous GABA under salinity stress.</p>Methods<p>Thus, we evaluated the effect of exogenous GABA (1.5 mM) on the growth and physiobiochemicalresponse mechanism of mungbean plants to saline stress (0-, 50-, and 100 mM [NaCland Na2SO4, at a 1:1 molar ratio]).…”

Table_1_Exogenous γ-aminobutyric acid (GABA) mitigated salinity-induced impairments in mungbean plants by regulating their nitrogen metabolism and antioxidant potential.docx by Abd Ullah (6529958)

“…However, it remains largely unknown how mungbean plants (Vigna radiata L.) respondto exogenous GABA under salinity stress.</p>Methods<p>Thus, we evaluated the effect of exogenous GABA (1.5 mM) on the growth and physiobiochemicalresponse mechanism of mungbean plants to saline stress (0-, 50-, and 100 mM [NaCland Na2SO4, at a 1:1 molar ratio]).…”

The mass water content of paddy soil after harvest is strongly associated with the accumulation of organic matter as the source of available nitrogen by Hideo Azuma (12063243)

“…Additionally, we investigated year-to-year variation in MWH using topsoil samples collected before autumn tillage, for 3–5 consecutive years in 24 plots, for various soil types throughout Japan. …”

The feeding habits of the endemic Remo flounder, Oncopterus darwinii (Actinopterygii: Pleuronectidae), in an exposed sandy beach’s surf zone in southern Brazil by Fábio R. Lameiro (5551088)

“…We studied the occurrence and diet of juveniles of this flatfish (85% < 100 mm TL) for one year (August 2009 to July 2010) in a southern Brazilian sandy beach. …”

Sodium bicarbonate treatment for QRS widening in bupropion overdoses by Michael Simpson (2990385)

“…No patient had a QRS duration < 100 milliseconds after the initial bicarbonate dose. …”