Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues by Lindsay B. Tulloch (1266861)

“…<div><p>Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of <b>compound 1</b>, a bis-tetrahydropyran 1,4-triazole (B-THP-T) inhibitor. …”

Image5_The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.JPEG by Vladimir M. Pogorelov (133492)

“…Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2AR) limit their clinical use in diverse settings. …”

Estimation the degree of essentialized human qualities (average of the five qualities) for each of the 16 individual robots, presented as a function of the degree of human resembla... by Tatjana A. Nazir (12262825)

Dosing analysis of the YFV vaccine (subcutaneous route) in interferon-1 receptor knockout mice (A129). by Ana C. Vicente Santos (11649118)

Down-regulation of VCAN or THBS2 decreased the cell proliferation in A549 cells. by Tzu-Yang Weng (2938080)

Homozygous deletion of <i>ERG251</i> results in decreased fitness at low initial cell density and increased fitness in the presence of low concentrations of FLC (≤1μg/ml). by Xin Zhou (54275)

Table_1_Effectiveness of Improved Use of Chewing Gum During Capsule Endoscopy in Decreasing Gastric Transit Time: A Prospective Randomized Controlled Study.XLS by Liang Huang (114017)

“…<p>Background/Aim: Chewing gum throughout small bowel capsule endoscopy (SBCE) increases completion rates (CRs) but decreases small bowel transit time (SBTT) and diagnostic yield (DY). …”

Table_1_Effectiveness of Improved Use of Chewing Gum During Capsule Endoscopy in Decreasing Gastric Transit Time: A Prospective Randomized Controlled Study.XLS by Liang Huang (114017)

“…<p>Background/Aim: Chewing gum throughout small bowel capsule endoscopy (SBCE) increases completion rates (CRs) but decreases small bowel transit time (SBTT) and diagnostic yield (DY). …”

Data Sheet 1_Lack of association between genetic variations in CYP3A5 and blood pressure or hypertension risk in the UK biobank.pdf by Pia Leibold (21390134)

“…While some previous studies reported that CYP3A5 variants were associated with decreased blood pressure and risk of HTN, others reported no associations. …”

A Unique Modification of the Eukaryotic Initiation Factor 5A Shows the Presence of the Complete Hypusine Pathway in <em>Leishmania donovani</em> by Bhavna Chawla (176976)

“…<div><p>Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of an unusual amino acid hypusine (<em>N</em>^€-(4-amino-2-hydroxybutyl) lysine), which is present on only one cellular protein, eukaryotic initiation factor 5A (eIF5A). We present here the molecular and structural basis of the function of DOHH from the protozoan parasite, <em>Leishmania donovani,</em> which causes visceral leishmaniasis. …”

P-Rex-deficient Purkinje neurons have normal passive membrane properties and basal synaptic transmission. by Claire Jackson (362873)

Hypoxia and Cobalt decrease AQP5 mRNA by down-regulating AQP5 transcription. by Jitesh D. Kawedia (384551)

The importance of entry criteria from the point of view of the SD method ‐ combinations B1 –B5. by Roman Vavrek (13200141)

Irbesartan Decreases ¹⁴C-FDG and ^99mTc-annexin A5 Accumulation Levels. by Yan Zhao (58882)

Subjects:

miR-146a and miR-155 levels decrease at the convalescent stage in patients with <i>V</i>. <i>cholerae</i> O1 infection. by Aziz Bitar (257322)

Amygdala voxel correlations with ACC whose values <i>decrease</i> as symptoms of post-combat emotional distress increase. by Tom Brashers-Krug (762715)

“…Threshold for significance was a <i>z</i>-score < -5.39. Coronal slices through the brain at y = 4, 2, 0, -2, -4, -6, and -8 mm showing the amygdala bilaterally. …”

ACC voxel correlations with amygdala whose values <i>decrease</i> as symptoms of post-combat emotional distress increase. by Tom Brashers-Krug (762715)

“…Threshold for significance was a <i>z</i>-score < -5.39. Only values within the ACC ROI are shown. …”

Data_Sheet_1_Low bone mineral density is associated with gray matter volume decrease in UK Biobank.docx by Polona Kalc (12642145)

“…Objectives<p>Previous research has found an association of low bone mineral density (BMD) and regional gray matter (GM) volume loss in Alzheimer’s disease (AD). We were interested whether BMD is associated with GM volume decrease in brains of a healthy elderly population from the UK Biobank.…”

Increased BBB disruption, with a decrease in endothelial ZO-1, claudin-5 and occludin, avoided by GM6001. by Saran Feng (345936)

image2_Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis Activity Disrupts CML malignancy.tif by Hui-Min Liu (3323370)

“…Treating CML cells with leonurine significantly decreased miR-18a-5p expression. Moreover, we found miR-18a-5p repressed SOCS5 by directly targeting its 3′-UTR. miR-18a-5p downregulation induced by leonurine reduced the biological activity of CML cells by relieving miR-18a-5p repression of SOCS5 expression. …”