Spectroscopic and Theoretical Study of Cu^I Binding to His111 in the Human Prion Protein Fragment 106–115 by Trinidad Arcos-López (2542546)

“…Cu^I coordination to His111 is pH-dependent: at pH >8, 2N1O1S species are formed with one Met ligand; in the range of pH 5–8, both methionine (Met) residues bind to Cu^I, forming a 1N1O2S species, where N is from His111 and O is from a backbone carbonyl or a water molecule; at pH <5, only the two Met residues remain coordinated. …”

<i>Sphagnum</i> Mosses - Masters of Efficient N-Uptake while Avoiding Intoxication by Christian Fritz (507612)

“…The interacting effects of rain N concentration and exposure time on moss N-uptake rates are, however, poorly understood.</p><p>We investigated the effects of N-concentration (1, 5, 10, 50, 100, 500 µM), N-form (¹⁵N - ammonium or nitrate) and exposure time (0.5, 2, 72 h) on uptake kinetics for <i>Sphagnum magellanicum</i> from a pristine bog in Patagonia (Argentina) and from a Dutch bog exposed to decades of N-pollution.…”

Correlation of Cervical Cancer Mortality with Fertility, Access to Health Care and Socioeconomic Indicators by Diama Bhadra Vale (6879314)

“…In the multivariate analysis, only fertility rate was significantly associated with the CC mortality rate (coefficient of correlation: 9.38; 95% confidence interval [CI]: 5.16-13.59). Conclusion A decrease in the fertility rate, as expected when the level of development of the regions increases, is related to a decrease in the mortality rate of CC. …”

Alteration of cellular levels of Smad2/3, pSmad2/3, Smad4, and Smad7 in NRK cells exposed to β-HB then treated with DA extract. by Shu-Fen Liu (299474)

“…B–E: Data were scanned and normalized to β-actin. β-HB treatment resulted in increased expression of Smad2/3, pSmad2/3 and Smad4, and a decrease in Smad7 expression; importantly, DA extract significantly reversed β-HB-induced increases in Smad2/3, pSmad2/3 and Smad4, and the concomitant decrease in Smad7. …”

Anti-inflammatory effects of <i>Capparis ecuadorica</i> extract in phthalic-anhydride-induced atopic dermatitis of IL-4/Luc/CNS-1 transgenic mice by Bo Ram Song (6585197)

“…PA + MCE treated Tg mice showed decreasing infiltration of mast cells (42.5%), iNOS-mediated COX‐2 induction pathway, MAPK signalling pathway and inflammasome activation in the ear tissue.…”

DataSheet_1_Exoantigens of Paracoccidioides spp. Promote Proliferation and Modulation of Human and Mouse Pulmonary Fibroblasts.pdf by Débora de Fátima Almeida Donanzam (9582911)

“…<p>Paracoccidioidomycosis (PCM) is a systemic granulomatous fungal infection caused by thermally dimorphic fungi of the genus Paracoccidioides. …”

Supplementary Material for: Endothelial Dysfunction of the Peripheral Vascular Bed in the Acute Phase after Ischemic Stroke by Scherbakov N. (4129753)

“…A decreased RHI was observed in cardioembolic and lacunar infarcts and stroke of undetermined etiology (1.7 ± 0.4, 1.8 ± 0.5 and 1.7 ± 0.3, p < 0.0001). …”

Determinants of coronary flow reserve in non-diabetic patients with chest pain without myocardial perfusion defects by Helena U. Westergren (758365)

“…Secondly, we investigated association between cardiovascular parameters and decreased CFR in a sex specific manner.…”

Tuning of Msn2 expression in rapidly growing cells. by Michal Chapal (7961111)

“…(F–G) Noisy Msn2 expression decreases stress protection and growth rate: we generated six strains with Msn2-YFP expressed under different promoters, which control genes with noisier expression than Msn2 but have a similar mean abundance (mean abundance in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000289#pbio.3000289.s005" target="_blank">S5 Fig</a>), and deletion of <i>MSN4</i>. …”

Data_Sheet_1_Testing the Analytical Rumination Hypothesis: Exploring the Longitudinal Effects of Problem Solving Analysis on Depression.DOCX by Marcela Sevcikova (7005413)

“…The two groups engaged in a similar degree of PSA. Findings from a multiple regression suggested that more PSA at Week 1 was related to a decrease in depressive symptoms at Week 5, even after controlling for baseline depression, problem number, and complexity. …”

Data_Sheet_1_Unprecedented Retention Capabilities of Extensive Green Roofs—New Design Approaches and an Open-Source Model.PDF by Kristian Förster (6002435)

“…We consider varying flow length and slope. The novelty lies especially in the consideration of flow lengths beyond 5 m and non-declined roofs. …”

Changes of best-correct visual acuity, central retinal thickness, and subfoveal choroidal thickness among the 4 groups. by Mio Matsubara (8486133)

“…(B) Changes of central retinal thickness among the 4 groups. Mean central retinal thickness(CRT) significantly decreased from 350±100 μm at baseline to 177±33μm at 6-month, 178±31μm at 12-month, and 196±62μm at 24-month (p = 8.9×10⁻⁵, 8.9×10⁻⁵ and 2.5×10⁻⁴, respectively) in Group 0, mean CRT also significantly decreased from 475±77 μm at baseline to 205±23μm at 6-month, 197±24μm at 12-month, and 192±33μm at 24-month (p = 1.2×10⁻², 1.2×10⁻² and 1.2×10⁻², respectively) in Group 1, mean CRT significantly decreased from 400±104 μm at baseline to 207±60μm at 6-month, 221±75μm at 12-month, and 194±47μm at 24-month (p = 8.3×10⁻⁶, 3.3×10⁻⁵ and 9.3×10⁻⁶, respectively) in Group 2, and mean CRT decreased from 294±62 μm at baseline to 250±104μm at 6-month, 197±44μm at 12-month, and 238±74μm at 24-month (p = 0.25, 2.8×10⁻² and 5.8×10⁻², respectively) in Group 3. …”

Variation in actuarial senescence does not reflect life span variation across mammals by Guillaume Péron (655312)

“…Combining the two steps, we computed the relative contribution of each of the five parameters to the variance in life span across species. …”

Negative selection on reassortment. by Mara Villa (2855789)

“…<p>(a) The cumulative distribution of mean nucleotide distances <i>d</i> between reassortant and parent strains for the HA-NA reassortments in influenza A/H3N2 (red line) is compared to the corresponding distribution of distances for co-circulating strains in the same influenza season (solid blue line) and from the New York area only [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006685#ppat.1006685.ref028" target="_blank">28</a>] (dashed blue line). …”

DataSheet_1_The Efficacy and Safety of Anlotinib Combined With PD-1 Antibody for Third-Line or Further-Line Treatment of Patients With Advanced Non-Small-Cell Lung Cancer.doc by Chongya Zhai (10155629)

“…The common grades 1–2 adverse events were fatigue 10/22 (45.5%), decreased appetite 9/22 (40.9%), hypertension 10/22 (45.5%); the common grades 3–4 adverse events were hypertension 2/22 (9.1%) and mouth ulceration 2/22 (9.1%).…”

Prevalence, Awareness, Treatment, and Control of Hypertension in United States Counties, 2001–2009 by Casey Olives (139016)

“…Over the last decade, national-levels of controlled hypertension have increased, but little information on hypertension prevalence and trends in hypertension treatment and control exists at the county-level. We estimate trends in prevalence, awareness, treatment, and control of hypertension in US counties using data from the National Health and Nutrition Examination Survey (NHANES) in five two-year waves from 1999–2008 including 26,349 adults aged 30 years and older and from the Behavioral Risk Factor Surveillance System (BRFSS) from 1997–2009 including 1,283,722 adults aged 30 years and older. …”

Supplementary Material for: How Much Do Focal Infarcts Distort White Matter Lesions and Global Cerebral Atrophy Measures? by Wang X. (2828795)

“…At follow-up, median 39 months later (IQR 30–45), 3 patients had a de novo stroke lesion; total stroke lesion volume had decreased in 11 and increased in 22 patients: WML volume was 12.17 ml (IQR 8.54–19.86) excluding versus 14.79 ml (IQR 10.02–38.03) including total stroke lesions (p < 0.001). …”

Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques by Pingchao Li (543008)

“…Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 10⁵ genome copies per ml plasma, SIV^hi) but not in macaques with low viral loads (< 10⁵, SIV^low). …”

Action of anandamide (AEA, 400 µM) on planar lipid bilayers: effect of cholesterol. by Eric Di Pasquale (373571)

“…<p><i>A–B</i>. superimposed currents across a bilayer constituted of POPC alone (<i>A</i>), held at 0 mV, in response to a rectangular pulse (+180 mV, 200 ms), before (control, light grey bilayer alone), and after addition of anandamide (heavy grey, +5, +25 min after AEA injection). …”

Table_1_Immune Monitoring of Patients With Primary Immune Regulation Disorders Unravels Higher Frequencies of Follicular T Cells With Different Profiles That Associate With Alterat... by María Soledad Caldirola (9575969)

“…These alterations confirmed the existence of an imbalance in the cTfh1/cTfh17 ratio in these diseases. In addition, we unraveled a marked dysregulation in the B cell compartment, characterized by a prevalence of transitional and naïve B cells in STAT1 GOF and CVID patients, and of switched-memory B cells and plasmablast cells in the STAT5b deficient patient. …”