Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC). …”

Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model by Christopher C. Marvin (1338228)

“…We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody–drug conjugate (ADC). …”

<i>Fkbp5</i> DNA methylation decreases with age in mice. by Jonathan J. Sabbagh (626366)

Image 1_A COP1-HY5-ABI5 module regulates ABA-mediated post-germination developmental arrest.pdf by Deeksha Singh (11009626)

“…Together, our results support a model in which a double-negative feedback loop between HY5 and ABI5 contributes to ABA-mediated post-germination growth arrest.…”

Fig 5 - by Christophe Verbist (6104075)

Exploring reopening strategies for a high range in disease transmission <i>v</i>_<i>r</i> with high testing capacity. by Mackenzie Dalton (14093874)

PI3K activity is required for induction of cerebellar LTP. by Claire Jackson (362873)

Modeling the Shape and Stability of Co Nanoparticles as a Function of Size and Support Interactions through DFT Calculations and Monte Carlo Simulations by Enrico Sireci (12127349)

Overexpression of TNFAIP9 alleviated the renal fibrosis caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Subjects:

Overexpression of TNFAIP9 remitted the renal inflammation caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Subjects:

Table_1_When and Why Did Human Brains Decrease in Size? A New Change-Point Analysis and Insights From Brain Evolution in Ants.XLSX by Jeremy M. DeSilva (7247009)

“…<p>Human brain size nearly quadrupled in the six million years since Homo last shared a common ancestor with chimpanzees, but human brains are thought to have decreased in volume since the end of the last Ice Age. …”

Computational Prediction and Analysis of Envelop Glycoprotein Epitopes of DENV-2 and DENV-3 Pakistani Isolates: A First Step towards Dengue Vaccine Development by Hafsa Amat-ur-Rasool (702613)

“…There is no effective vaccine available, so far, against any of its four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). There is a need for the development of preventive and therapeutic vaccines against DENV to decrease the prevalence of dengue fever, especially in Pakistan. …”

S5 Table - by Marisa R. Pinson (11659514)

Overexpression of TNFAIP9 counteracted the renal damage caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Subjects:

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure by Wei Meng (505670)

“…Due to the increased polarity at C2, the permeability for these compounds decreased. Further adjustment of the polarity by replacing the N1 2,6-dimethoxyphenyl group with a 2,6-diethylphenyl group and reoptimization for the potency of the C5 pyrroloamides resulted in potent compounds with improved permeability. …”

Developmental regulation of the decrease in adhesion. by Marco Tarantola (102609)

Excessive LF4A kinase activity shortens cilia and decreases IFT. by Yu-Yang Jiang (7036916)

Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues by Lindsay B. Tulloch (1266861)

“…<div><p>Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising trypanocidal activity of <b>compound 1</b>, a bis-tetrahydropyran 1,4-triazole (B-THP-T) inhibitor. …”