Detection of epistasis is confined in a time window whose width is controlled by the mean selection coefficient. by Gabriele Pedruzzi (5753792)

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A by Fiona Fernandes (251389)

“…Mutations in NS5A alone conferred decreased CsA susceptibility regardless of NS5B mutations.…”

Hypoxia induced decreases in dendritic spine density, length, soma size and volume of the apical and basal branches of CA1 and CA3 pyramidal neurons. by Chun-Sing Lam (695733)

Mutation of four arginine residues in P34 leads to a decrease in binding between P34 and L5. by Anyango D. Kamina (4034165)

Environmental Enrichment on <i>Mecp2^−/y</i>-EE mice induces a decrease in the expression of a set of synaptic plasticity-related genes. by Bredford Kerr (363408)

Fig 5 - by Melissa A. Hill (13170105)

NBCe1 and NBCe2 protein and mRNA expression in hRPTCs carrying wild-type (WT) or homozygous variant (HV) <i>SLC4A5</i>. by John J. Gildea (845025)

“…<b>D) <i>SLC4A4</i> mRNA.</b> <i>SLC4A4</i> mRNA is decreased following an increase in intracellular sodium (monensin, 1 μmol/L, 24 h) (↑Na⁺) only in WT <i>SLC4A5</i> hRPTCs (N = 9, *P<0.05 vs. …”

Overview of study procedures. by Matthew G. Vinson (22593374)

“…VIDEO and CONTROL were associated with a similar rise in intent to decrease OTC NSAID use (1.92 (SD: 4.41) vs. 1.36 (SD: 3.46), p = 0.150) and a similar decrease in NSAIDs exposure (−32.8% in VIDEO and −36.5% in CONTROL, p = 0.520) 4 weeks post-intervention. …”

AUC statistics as calculated from simulated time series. Each statistical metric was calculated within sliding windows, throughout the pre-critical interval. We considered five-, fifteen-, and thirty-day sliding windows. Given that the temperature of the system increased to 12°C on day sixty, we also considered three pre-critical intervals: Days 1 to 60, Days 20 to 60, and Days 30 to 60. To evaluate trends in these metrics, we calculated Kendall’s rank correlation coefficient during the pre-critical interval, and compared control (constant temperature, non-epidemic) and warming (warming treatment, epidemic emergence) coefficients across simulations and experimental populations by calculating the area under the curve (AUC) statistic. Values less than 0.5 suggest that a decrease in the statistical metric indicates emergence, while values greater than 0.5 suggest that an increase in the statistical metric indicates emergence, with more extreme values indicating stronger tre by Madeline Jarvis-Cross (22394247)

“…Values less than 0.5 suggest that a decrease in the statistical metric indicates emergence, while values greater than 0.5 suggest that an increase in the statistical metric indicates emergence, with more extreme values indicating stronger tre</p>…”

Levels of resistance of alphavirus RNA translation to IFN-β is determined by 5’UTRs of their genomes. by Josephine M. Reynaud (732822)

Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…We report the synthesis and characterization of 14 complexes of the type (Au(R)[N̂N])⁺, where R = tunable biaryldialkyl phosphine ligands and [N̂N] = bidentate phenanthroline derivatives as anticancer agents. …”

Genes involved in lipid metabolism that are differentially expressed in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

Genes involved in carbohydrate metabolism differentially expressed in liver of <i>Fmo5</i>^<i>-/-</i> mice compared with WT mice. by Ian R. Phillips (5074121)

S5 Fig - by Jordan K. Abbott (8934239)

Inactivation of the <i>WNT5A</i> Alternative Promoter B Is Associated with DNA Methylation and Histone Modification in Osteosarcoma Cell Lines U2OS and SaOS-2 by Himani Vaidya (3179403)

“…In this study, we analyzed expression from two of the major <i>WNT5A</i> promoters, termed promoter A and promoter B, in normal human osteoblasts, SaOS-2 and U2OS osteosarcoma cell lines, and osteosarcoma tumor tissue. …”

Image 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.tif by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Table 5_Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways.doc by Yu Zhang (12946)

“…</p>Discussion<p>Our research emphasizes the critical role of C1QTNF1-AS1 in the pathogenesis of osteosarcoma (OS). We discovered that the downregulation of C1QTNF1-AS1 indirectly upregulates the expression of LDHA and PDK3 by suppressing miR-34a-5p, which functions as a regulator of the Warburg effect. …”

Inhibition of G9a decreases the tumorigenicity of neuroblastoma cells. by Xiao-Xue Ke (626989)

Concentrations of 5-HT and 5-HIAA in brain tissue. by Thibault Renoir (348572)

“…Both 5-HT and 5-HIAA concentrations were decreased in the hippocampus (A/B), the cortex (C/D) and the striatum (E/F) in female HD mice when compared to WT animals. …”

<i>TUFT1</i>, a novel candidate gene for metatarsophalangeal osteoarthritis, plays a role in chondrogenesis on a calcium-related pathway by Eeva Sliz (3927023)

“…The variant reduced <i>TUFT1</i> mRNA and tuftelin protein expression in HEK293 cells. ATDC5 cells overexpressing wild type (wt) or mutant <i>TUFT1</i> were cultured in calcifying conditions and chondrogenic differentiation was found to be inhibited in both cell populations, as indicated by decreased marker gene expression when compared with the empty vector control cells. …”