Cylindrospermopsin toxicity in mice following a 90-d oral exposure by N. Chernoff (5141828)

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

The Proteasome as a Drug Target in the Metazoan Pathogen, <i>Schistosoma mansoni</i> by Betsaida Bibo-Verdugo (4273624)

“…After 24 h, bortezomib and carfilzomib decreased worm motility by more than 85% and endogenous proteasome activity by >75%, and after 72 h, they increased caspase activity by >4.5-fold. …”

cKO embryos display a variety of defects in the yolk sac mesoderm. by Siyeon Rhee (390224)

“…<p>A–B, D–E) Whole mount immunofluorescence of 9.5 <i>dpc</i> WT (A–B) or mutant (D–E) yolk sacs (YS) using the endothelial marker PECAM (green) and the vascular smooth muscle marker (αSMA) demonstrates that the large disorganized vessels in the cKO (D) are not surrounded by αSMA (E). …”

A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between <i>osm-3</i> and <i>nphp-4</i> by Svetlana V. Masyukova (849325)

“…Four loci have been identified, three of which are established ciliopathy genes <i>mks-1</i>, <i>mks-2</i>, and <i>mks-5</i>. The fourth allele (<i>yhw66</i>) is a missense mutation (S316F) in OSM-3, a kinesin required for cilia distal segment assembly. …”

Data Sheet 1_A systematic review of the effects of nanoplastics on fish.pdf by Asok K. Dasmahapatra (2275549)

“…To assess the toxic effects of NAPs, particularly their genotoxicity in fish, we carried out a bibliographic search in PubMed using the search terms “nanoplastics” and “fish,” which yielded 233 articles. …”

Results of Influenza Vaccination: Short Follow-Up Study of a Turkish Population by Guzin Zeren Ozturk (10372287)

“…<div><p>Abstract INTRODUCTION: The trivalent inactivated influenza vaccine was approved for use in Turkey during the 2018-2019 influenza season. We evaluated beliefs regarding the vaccine and vaccination outcomes in a Turkish population. …”

Control of Severe, Life-Threatening External Bleeding in the Out-of-Hospital Setting: A Systematic Review by Nathan P. Charlton (6056651)

SERBP1 is a component of the Liver Receptor Homolog-1 transcriptional complex by Yelenis Mari (725499)

“…In contrast, receptor overexpression decreased only SERBP1 mRNA levels. Consistent with these data, in a promoter:reporter assay, binding of NR5A2 to the promoter region of SERBP1 resulted in a decrease in the expression level of the reporter gene, and subsequently, inhibiting transcription. …”

SERBP1 is a component of the Liver Receptor Homolog-1 transcriptional complex by Yelenis Mari (725499)

“…In contrast, receptor overexpression decreased only SERBP1 mRNA levels. Consistent with these data, in a promoter:reporter assay, binding of NR5A2 to the promoter region of SERBP1 resulted in a decrease in the expression level of the reporter gene, and subsequently, inhibiting transcription. …”

(A) Longitudinal sections of soleus immunostained using antiserum 46 to plectin by Patryk Konieczny (47697)

The power-law exponent for both the (a) positive and (b) negative tail. by Lu Liu (171341)

“…<p> decreases from Bach to Mendelsohn/Chopin [Note the horizontal coordinates corresponding to the five symbols in either (a) or (b) denote the birth years of the five composers from Bach to Chopin, respectively]. …”

A Randomized, Crossover Study to Evaluate the Pharmacokinetics of Amantadine and Oseltamivir Administered Alone and in Combination by Dennis Morrison (272746)

“…Among the therapies considered for use in pandemic influenza is the co-administration of ion channel and neuraminidase inhibitors, both to potentially increase efficacy as well as to decrease the emergence of resistant isolates. To better understand the potential for drug interactions, a cross-over, randomized, open-label trial was conducted with amantadine, 100 mg po bid, and oseltamivir, 75 mg po bid, given alone or in combination for 5 days. …”

A standardized post-cesarean analgesia regimen reduces postpartum opioid use by Melissa F. Meyer (11339199)

“…</p> <p>To determine if implementation of a standardized postoperative analgesic regimen decreases opioid use following cesarean birth.…”

Optimal Dose and Method of Administration of Intravenous Insulin in the Management of Emergency Hyperkalemia: A Systematic Review by Ziv Harel (2696983)

“…There was no statistically significant difference in mean decrease in serum potassium (K⁺) concentration at 60 minutes between studies in which insulin was administered as an infusion of 20 units over 60 minutes and studies in which 10 units of insulin was administered as a bolus (0.79±0.25 mmol/L versus 0.78±0.25 mmol/L, <i>P</i> = 0.98) or studies in which 10 units of insulin was administered as an infusion (0.79±0.25 mmol/L versus 0.39±0.09 mmol/L, <i>P</i> = 0.1). …”

Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet by A.C. Colpo (4651558)

Nanoporous Silica Preconcentrator for Vapor-Phase DMNB, a Detection Taggant for Explosives by Coco Day (9121340)

“…The loading time and loading temperature of pSiO₂ were varied systematically between 15 and 60 min and 5–20 °C, respectively. The preconcentrator’s performance was compared to that of a nonporous substrate of the same material as a control. …”

The Effect of Probiotic Treatment on Patients Infected with the H7N9 Influenza Virus by Xinjun Hu (412383)

“…<div><p>Background</p><p>A novel avian-origin influenza A (H7N9) virus emerged and spread among humans in Eastern China in 2013. …”