Bridging Thermodynamics, Antimicrobial Activity, and pH Sensitivity of Cationic Membranolytic Heptapeptides–A Computational and Experimental Study by Suvankar Ghosh (812058)

“…Understanding the thermodynamics of peptide:membrane binding and the factors that alter the stability is the key to designing potent and selective small antimicrobial peptides. Here, we report the thermodynamics, antimicrobial activity, and mechanism of a de novo designed seven residue long cationic antimicrobial peptide (P4: NH₃⁺-LK­WLK­KL-CONH₂, Charge +4) and its analogs (P5: Lysine’s → Arginine’s; P6: Lysine’s → Uncharged-Histidine’s; P7: Tryptophan → Leucine) by combining computation and experiments. …”

Bridging Thermodynamics, Antimicrobial Activity, and pH Sensitivity of Cationic Membranolytic Heptapeptides–A Computational and Experimental Study by Suvankar Ghosh (812058)

“…Understanding the thermodynamics of peptide:membrane binding and the factors that alter the stability is the key to designing potent and selective small antimicrobial peptides. Here, we report the thermodynamics, antimicrobial activity, and mechanism of a de novo designed seven residue long cationic antimicrobial peptide (P4: NH₃⁺-LK­WLK­KL-CONH₂, Charge +4) and its analogs (P5: Lysine’s → Arginine’s; P6: Lysine’s → Uncharged-Histidine’s; P7: Tryptophan → Leucine) by combining computation and experiments. …”

Bridging Thermodynamics, Antimicrobial Activity, and pH Sensitivity of Cationic Membranolytic Heptapeptides–A Computational and Experimental Study by Suvankar Ghosh (812058)

“…Understanding the thermodynamics of peptide:membrane binding and the factors that alter the stability is the key to designing potent and selective small antimicrobial peptides. Here, we report the thermodynamics, antimicrobial activity, and mechanism of a de novo designed seven residue long cationic antimicrobial peptide (P4: NH₃⁺-LK­WLK­KL-CONH₂, Charge +4) and its analogs (P5: Lysine’s → Arginine’s; P6: Lysine’s → Uncharged-Histidine’s; P7: Tryptophan → Leucine) by combining computation and experiments. …”

Image_2_Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19.tiff by Marina Luise Viola Azevedo (10503320)

“…However, the G allele (GG and GA) of rs3819025 was correlated with higher tissue expression of IL-17A in the COVID-19 group. SARS-CoV-2 virus evokes an exacerbated response of the host’s immune system but differs from that observed in the H1N1pdm09 infection since the IL-8/IL-17A tissue expression, and lung neutrophilic recruitment may be decreased. …”

Image_1_Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19.tiff by Marina Luise Viola Azevedo (10503320)

“…However, the G allele (GG and GA) of rs3819025 was correlated with higher tissue expression of IL-17A in the COVID-19 group. SARS-CoV-2 virus evokes an exacerbated response of the host’s immune system but differs from that observed in the H1N1pdm09 infection since the IL-8/IL-17A tissue expression, and lung neutrophilic recruitment may be decreased. …”

Table_1_Lung Neutrophilic Recruitment and IL-8/IL-17A Tissue Expression in COVID-19.docx by Marina Luise Viola Azevedo (10503320)

“…However, the G allele (GG and GA) of rs3819025 was correlated with higher tissue expression of IL-17A in the COVID-19 group. SARS-CoV-2 virus evokes an exacerbated response of the host’s immune system but differs from that observed in the H1N1pdm09 infection since the IL-8/IL-17A tissue expression, and lung neutrophilic recruitment may be decreased. …”

Data_Sheet_1_Diagnostic value of cardiac miR-126-5p, miR-134-5p, and miR-499a-5p in coronary artery disease-induced sudden cardiac death.docx by Linfeng Li (281571)

“…The expressions of cardiac miR-126-5p, miR-134-5p, and miR-499a-5p were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR).…”

Flowchart of data preprocessing steps. by Ehsan Yaghmaei (16985784)

“…Two of the most commonly prescribed such drugs are Donepezil and Memantine. We formally tested and confirmed the presence of a beneficial drug-drug interaction of Donepezil and Memantine using a causal inference analysis. …”

PGE₂ signals through <i>Ptger2</i> to decrease <i>Sost</i> expression. by Damian C. Genetos (325684)

Distribution of 37 stunting priority districts by food security status and number of problem nutrients in under-five children. by Umi Fahmida (10007846)

Schematic diagram of the molecular mechanism by which TRIM37 improves MS by stabilizing PEX5 through monoubiquitination. by Lai Jiang (2401513)

CpG/c stimulated CLL B cells decrease LEF-1 expression and increase PRDM1 expression. by Albert Gutierrez Jr. (342562)

Dox-inducible expression of HA-MAD1 in colon is sufficient to decrease p53 expression and cause chromosome missegregation. by Sarah E. Copeland (13951506)

“…Large circles show mean of cells from 5 fields of view from a single animal. (D) Immunoblot showing p53 protein expression is decreased in colon tissue from 5-month old HA-MAD1 mice after 1 week of 6 mg/kg dox feed as compared to control. …”

Recombinant α-SNAP halts the AR at a stage when SNAREs are monomeric. by Facundo Rodríguez (213557)

“…<p><i>A</i>, we incubated SLO-permeabilized sperm with 300 nM α-SNAP for 10 min at 37°C followed by 100 nM light chain of TeTx, and 0.5 mM CaCl₂ for an additional 10 min (<i>G</i>, <i>H</i>, <i>I</i>). …”

Estimates Vaccine effectiveness of inactivated vaccine BBIBP-CorV against COVID-19-associated severe or critical hospitalization according to age and gender over time since second... by Jihane Belayachi (51116)

Table_1_Persistence of Antibodies Against Spike Glycoprotein of SARS-CoV-2 in Healthcare Workers Post Double Dose of BBV-152 and AZD1222 Vaccines.DOCX by Hari Ram Choudhary (10884963)

“…<p>Purpose: We investigated the persistence of the vaccine-induced immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) in Odisha who received a complete dose of either Covaxin or Covishield vaccine.…”

Decrease in parasite biomass and IRBC accumulation in organs from CD8⁺ T cell-depleted WT mice. by Carla Claser (185910)

The serotonin biosynthetic enzyme TPH-1 is required in chemosensory neurons to inhibit the Dar phenotype and decrease pathogen clearance rates. by Alexandra Anderson (97972)

Altered ERK 1/2 and Smad 1/5/8 phosphorylation observed in primary rat hippocampal cells upon iAβ expression. by Eric Cruz (340766)

“…Decreased ERK 1/2 phosphorylation in iAβ expressing cells is rescued upon pre-treatment with PLX4032. …”

Table_5_Correlation analysis between body composition, serological indices and the risk of falls, and the receiver operating characteristic curve of different indexes for the risk... by Kexin Zhang (301752)