Local Gene Silencing of Monocyte Chemoattractant Protein-1 Prevents Vulnerable Plaque Disruption in Apolipoprotein E-Knockout Mice by Xiao Ling Liu (178263)

“…The present study was undertaken to test the hypothesis that local RNAi of MCP-1 by site-specific delivery of adenovirus-mediated small hairpin RNA (shRNA) may enhance plaque stability and prevent plaque disruption in ApoE−/− mice. We designed an adenovirus-mediated shRNA against mouse MCP-1 (rAd5-MCP-1-shRNA). …”

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation by Vittoria Massafra (613864)

“…Our analyses provide a resource of FGF19 target proteins in the liver. 189 proteins were upregulated (≥ 1.5 folds) and 73 proteins were downregulated (≤ -1.5 folds) by FGF19. …”

DataSheet_1_Influence of beam pruning techniques on LET and RBE in proton arc therapy.docx by Helge Henjum (16931607)

“…Similar results were found for the ependymoma and the rhabdomyosarcoma case. We demonstrated a PAT pruning technique that can increase both LET and RBE in the target volume and at the same time decreased values in healthy tissue, without affecting the target volume dose coverage.…”

Degradation of collagen content and structure in the peripartum cervix at term and in preterm birth. by Steven M. Yellon (495220)

“…By example, the ^b assigned to the Ona D17.5 group indicates, by comparison, a significant decrease in OD of cervix sections from the RU486 D17.5, Ovx D17.5, and Ona PTB groups (greater collagen content and structure). …”

Model predictions for N vs. P limitation in the youngest Hawai’i and Franz Josef sites. by Duncan N. L. Menge (145217)

“…Input and nutrient use efficiency parameters come from the 300 year old Hawaiian site (<i>I_N</i> = 9.6 kg N ha⁻¹ y⁻¹, <i>I_P</i> = 0.63 kg P ha⁻¹ y⁻¹, <i>ω_N = </i>382 g C g N⁻¹, <i>ω_P</i> = 6780 g C g P⁻¹<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042045#pone.0042045-Vitousek5" target="_blank">[37]</a>) and the 5–7 year old New Zealand site (<i>I_N</i> = 1.5 kg N ha⁻¹ y⁻¹<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042045#pone.0042045-Menge8" target="_blank">[78]</a>, <i>I_P</i> = 2.2 kg P ha⁻¹ y⁻¹–calculated from the decrease in soil inorganic P from the 5 to the 60 year old site–<i>ω_N = </i>45 g C g N⁻¹, <i>ω_P</i> = 643 g C g P⁻¹<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042045#pone.0042045-Richardson1" target="_blank">[5]</a>), with the other parameters as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042045#pone-0042045-g005" target="_blank">Fig. 5a</a>.…”

Summary of <i>CHL1</i> expression in 11 tumor types as measured with the Clontech Cancer Profiling Arrays I and II. by Vera N. Senchenko (53211)

GOAT MILK MANGO YOGHURTS: PHYSICOCHEMICAL STABILITY DURING OR STORAGE by Yvana Maria Gomes dos Santos (5959919)

“…The aim of this study is to assess the stability of the procedure in the production of processed yogurt with goat milk and sleeve pulp. Five different yogurt formulations were processed using varying concentrations of sucrose (5, 10 and 15%) and mango pulp (4, 5 and 6%). …”

Prevalence of self-referred chronic pain and intercurrences in the health of the elderly by Ezequiel Vitório Lini (5255471)

“…CONCLUSION: Measures to decrease chronic pain in the elderly should be priority, especially in primary health attention services, because this is a multidimensional and complex public health problem.…”

Paradigm and results of Experiment 2: Unambiguous pre-exposure. by Maartje Cathelijne de Jong (334147)

“…<p><b>A</b>) The paradigm. The pre-exposure period had a fixed duration (4.3 minutes) and contained either an ambiguous globe, a globe disambiguated using binocular depth-cues (disparity) or a globe disambiguated using monocular depth-cues (contrast- and size-imbalance). …”

Inhibiting S6K1 does not alter pFMRP S499 levels <i>in vivo</i>. by Christopher M. Bartley (560971)

“…(<b>C</b>) Quantification verifies a significant decrease in pS6:S6 but no change in pFMRP:FMRP following mTORC1 or S6K1 inhibition <i>in vivo</i>. …”

Comparison between selecting mt protein-coding (PC) genes by individual gene performance vs. by length. by Justin C. Havird (507301)

“…<p>Utilizing the three mt protein-coding (PC) genes that individually performed “best” (based on <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084080#pone-0084080-g003" target="_blank">Figure 3:</a> ND5, ND4, ND2), rather than the three longest (i.e, ND5, COX1, and ND4) mt PC genes, resulted in a significantly lower decrease in Ln <i>L</i> (± S.E.M.) compared to the “supergene” (i.e., all 13 mt PC genes) topology (<i>t</i>-test, <i>t</i> = 2.21, <i>df</i> = 1, 66, <i>P</i> = 0.03). …”

Characterization of urinary exosomes. by Tim Lange (2385133)

“…Zetasizer analysis of urinary exosome samples (C). The results of the 5 measurements of the urine sample displayed in TEM (A) are shown (C, a). …”

Endocytosed albumin co-localized with lysosomes and was degraded in podocytes. by John M. Carson (577297)

“…<p>Confocal microscopy image demonstrating co-localization of albumin and lysosomes in a podocyte treated with 1.5 mg/mL FITC-albumin and Cathepsin B Magic Red for 1 hour. …”

Activated carbon loaded with manganese and iron for glyphosate adsorption: Kinetics, isotherms and thermodynamic studies by Natalia Ueda Yamaguchi (6722057)

“…Adsorption isotherm experiments were carried out at 5, 15, 25, 35 and 45°C. The adsorption isotherms presented a better fitting using the Freundlich model (R2>0.98), indicating a multilayer adsorption of glyphosate. …”

OCT imaging during ON in MOG^TCRxThy1CFP mice by Katie Lidster (479714)

“…<p>(A) Histological changes in the thickness of RGC layer in control mice (n=5) and MOG^TCRxThy1CFP mice (n=5) at day 21. …”

Kinetics of PfR6 interaction with HMG-box. by Diego F. Joseph (6569912)

“…Mixing the labeled protein with the probe-bound aptamer (green) resulted in a decrease of fluorescence over time, indicating that the binding of both components results in the quenching of fluorescein due to its vicinity with the quencher in the protein. …”

Simulation of [Mg²⁺]_i–mediated changes of junctional conductance (black traces) measured in RIN cells expressing Cx36. by Mindaugas Snipas (3909556)

“…The fitted junctional conductance (g_j) kinetics (red trace) was obtained at ~4.5-fold V₀ increase and ~1000-fold p_c1→c2 decrease. …”

The Effect of p38MAPK on Cyclic Stretch in Human Facial Hypertrophic Scar Fibroblast Differentiation by Qi-cui Du (468638)

“…The fibroblasts were synchronized and randomly assigned to two groups: cyclic stretch and cyclic stretch pre-treated with SB203580 (a p38MAPK inhibitor). Cyclic stretch at 10% strain was applied at a loading frequency of 10 cycles per minute (i.e. 5 seconds of tension and 5 seconds of relaxation) for 0 h, 6 h and 12 h. …”

Kupffer cell populations. by Ivan Linares (5059373)

“…<p>Flow-cytometry analysis showed a significant decrease on pro-inflammatory NO+ KCs population in RGZ vs CTRL group since 1hr (28.49±4.99 vs 53.54±9.15%; p = 0.040), this difference further increase at 6hr (5.51±0.54 vs 31.12±9.58%; p = 0.009) and 24hr (4.15±1.50 vs 17.10±4.77%; p = 0.043) following reperfusion (A). …”

Homozygous <i>mray</i> mutants show severe craniofacial malformations starting early in development. by Adam P. Ross (437534)

“…<p><b>A, B,</b> Fluorescent images of a wild-type embryo compared to a homozygous <i>mray</i> littermate at E12.5. …”