Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment by Phung Nguyen (230474)

“…The <b>CHBC</b>–GPR17 interaction leads to a rapid decrease of cAMP and Ca²⁺. <b>CHBC</b> exhibits the cytotoxicity effect on GBM cells in a dose-dependent manner with an IC₅₀ of 85 μM, whereas the known agonist MDL29,951 showed a negligible effect. …”

PrA inhibited DC maturation responding to LPS and diminished DC-mediated T cell allostimulation. by Maomao Zhang (393240)

“…The highest dose induced a significant decrease in viable DC count, so only 5 nM and 20 nM were used in subsequent experiments. …”

Glyphosate alters the composition, but not density, of the <i>A</i>. <i>gambiae</i> midgut microbiota. by Daniel F. Q. Smith (10788903)

“…<p>(<b>A)</b> Glyphosate does not alter microbial density of the culturable mosquito midgut bacteria (grown on LB agar). …”

The Potential Connectivity of Waterhole Networks and the Effectiveness of a Protected Area under Various Drought Scenarios by Georgina O’Farrill (564895)

“…The Greater Calakmul Region of the Yucatan Peninsula (Mexico) has experienced a 16% decrease in precipitation over the last 50 years, which we hypothesise has affected water resource connectivity. …”

Table_1_Chemical-Shift-Encoded Magnetic Resonance Imaging and Spectroscopy to Reveal Immediate and Long-Term Multi-Organs Composition Changes of a 14-Days Periodic Fasting Interven... by Magalie Viallon (3140223)

“…Fat fraction, MRI relativity index T2^* and susceptibility (Chi), as well as Fatty acid composition, were calculated at all-time points.</p><p>Results: A decrease in body weight (BW: −9.5%), quadriceps muscle volume (−3.2%), Subcutaneous and Visceral Adipose Tissue (SAT −34.4%; VAT −20.8%), liver fat fraction (PDFF = 1.4 vs. 2.6 % at baseline) but increase in Spine Bone Marrow adipose tissue (BMAT) associated with a 10% increase in global adiposity fraction (PDFF: 54.4 vs. 50.9%) was observed. …”

Table_2_Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.xlsx by Inga Bae-Gartz (7062890)

Image_1_Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.tif by Inga Bae-Gartz (7062890)

Table_4_Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.xlsx by Inga Bae-Gartz (7062890)

Table_3_Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.xlsx by Inga Bae-Gartz (7062890)

Image_2_Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.tif by Inga Bae-Gartz (7062890)

Table_1_Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring.xlsx by Inga Bae-Gartz (7062890)

Image_1_Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.jpeg by Quan Liu (486219)

“…Increased contents of terminally differentiated HMGB1+ Granulosa and GSTA1+ Granulosa were observed in the ovaries of individuals aged 50-69. Signaling pathway activity analysis indicated a gradual decrease in TGFb and MAPK pathway activity with menopause progression, while p53 pathway activity increased. …”

Longitudinal fasting blood glucose patterns and arterial stiffness risk in a population without diabetes by Yuntao Wu (37012)

“…Multivariate regression model was used to estimate the difference of brachial-ankle pulse wave velocity levels and logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95%CIs) of arterial stiffness risk, according to the fasting blood glucose trajectories.</p><p>Results</p><p>We identified five distinct fasting blood glucose trajectories and each of the trajectories was labeled according to its range and change over 2006–2010 survey: elevated-stable pattern (5.0% of participants), elevated-decreasing pattern (6.6%), moderate-increasing pattern (10.9%), moderate-stable pattern (59.3%), and low-stable pattern (18.2%). …”

The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases by Claudia Pérez (351604)

“…All these alterations result in a reduced content of the moderate (MAT I) and high V_max (MAT III) isoenzymes, whereas the low V_max (MAT II) isoenzyme increases and nuclear accumulation of MAT I is observed. …”

DataSheet_1_Non-coding RNAs derived from the foot-and-mouth disease virus genome trigger broad antiviral activity against coronaviruses.pdf by Miguel Rodríguez-Pulido (298809)

“…When the in vivo efficacy of the FMDV ncRNAs was assessed in K18-hACE2 mice, administration of naked ncRNA before intranasal SARS-CoV-2 infection significantly decreased the viral load and the levels of pro-inflammatory cytokines in the lungs compared with untreated infected mice. …”

Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women by Jessica A. Grieger (6041222)

“…Women with MetS were at an increased risk for PE by a factor of 1.63 (95% CI 1.23 to 2.15) and for GDM by 3.71 (95% CI 2.42 to 5.67). …”

Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity by Takafumi Yotsumoto (4994390)

“…Furthermore, we searched for the biomarker related to the bone and cartilage toxicity using rats treated with ASB20123 at doses of 0.005, 0.05, 0.5, and 5.0 mg/kg/day for 4 weeks. …”

Phylodynamics of HIV-1 from a Phase III AIDS Vaccine Trial in Bangkok, Thailand by Marcos Pérez-Losada (159353)

“…Here, we used these data in combination with other publicly available gp120 sequences to perform a molecular surveillance and phylodynamic analysis of HIV-1 in Thailand.…”

Ultralow Lattice Thermal Conductivity in the Aikinite Structure Family, Cu_<i>x</i>Pb_<i>x</i>Bi_2–<i>x</i>S₃, and Thermoelectric Propertie... by Srikanth Balijapelly (8974346)

“…All the compounds exhibit a narrow band gap below 1.0 eV confirmed by diffuse reflectance spectroscopy. …”

TMEM43 Mutation p.S358L Alters Intercalated Disc Protein Expression and Reduces Conduction Velocity in Arrhythmogenic Right Ventricular Cardiomyopathy by Vinayakumar Siragam (455948)

“…A heterozygous missense mutation in the transmembrane protein 43 (TMEM43) gene, p.S358L, has been genetically identified to cause autosomal dominant ARVC type 5 in a founder population from the island of Newfoundland, Canada. …”